Mechanisms of Corneal Nerve Repair

角膜神经修复机制

• 批准号: 8969996
• 负责人: Mark I Rosenblatt
• 金额: $ 29.76万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-11-18 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8969996
• 关键词: Mechanisms; Corneal; Nerve; Repair

DESCRIPTION (provided by applicant): The cornea is the most densely innervated tissue in humans. Peripheral corneal nerves regenerate follow injury. Our hypothesis is that VEGF is a critical determinant of corneal nerve regeneration after injury and that the signaling pathways which mediate neurogenesis are distinct from those which mediate angiogenesis. Aim A will characterize the expression of VEGF and VEGF receptors and identify the receptors which mediate VEGF-dependent neurogenesis in vitro and in vivo. Aim B will characterize effect of VEGF on the regeneration of nerves in 2 injury models, while Aim C will investigate the pathways responsible for these effects. We will analyze whether there exists a differential activation of VEGF mediated neurogenesis following different injuries.

描述（由申请人提供）：角膜是人类神经支配最密集的组织。周围角膜神经在受伤后会再生。我们的假设是，VEGF 是损伤后角膜神经再生的关键决定因素，并且介导神经发生的信号通路与介导血管发生的信号通路不同。目标 A 将表征 VEGF 和 VEGF 受体的表达，并鉴定在体外和体内介导 VEGF 依赖性神经发生的受体。目标 B 将表征 VEGF 对 2 个损伤模型中神经再生的影响，而目标 C 将研究导致这些影响的途径。我们将分析不同损伤后 VEGF 介导的神经发生是否存在差异激活。

项目成果

Ambient Air Currents Activate Corneal Nerves During Ocular Desiccation in Rats: Simultaneous Recordings of Neural Activity and Corneal Temperature.

• DOI: 10.1167/iovs.18-24604
• 发表时间: 2018-08-01
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Hirata H;Dallacasagrande V;Mizerska K;Ivakhnitskaia E;Rosenblatt MI
• 通讯作者: Rosenblatt MI

Gene therapy of the corneal epithelium.

角膜上皮的基因治疗。

• DOI: 10.1097/00004397-200404430-00010
• 发表时间: 2004
• 期刊: International ophthalmology clinics
• 作者: Rosenblatt,MarkI;Azar,DimitriT
• 通讯作者: Azar,DimitriT