2020 Cranifacial Morphogenesis and Tissue Regeneration GRC/GRS

2020 颅面形态发生与组织再生 GRC/GRS

• 批准号: 9912417
• 负责人: PAMELA C YELICK
• 金额: $ 2.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-10 至 2021-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912417
• 关键词: Address; Animal Model; Automobile Driving; Basic Science; Biochemistry; Biocompatible Materials; Biology; Biomechanics; Biophysics; Cells; Cellular biology; Cephalic; Chemistry; Clinic; Clinical; Clinical Management; Clinical Sciences; Collaborations; Communities; Complex; Congenital Abnormality; Craniofacial Abnormalities; Dental; Development; Developmental Biology; Developmental Cell Biology; Diagnostic; Discipline; Disease; Disease Management; Disease model; Elements; Environment; Environmental Risk Factor; Event; Experimental Models; Exposure to; Face; FaceBase; Fostering; Foundations; Future; Genetic; Genetic Determinism; Goals; Head; Health; Human; Human Genetics; Interdisciplinary Study; International; Journals; Knowledge; Laboratory Study; Learning; Mathematics; Mechanics; Medical Genetics; Methods; Molecular; Molecular and Cellular Biology; Morphogenesis; National Institute of Dental and Craniofacial Research; Natural regeneration; Operative Surgical Procedures; Organ; Outcome; Participant; Pattern; Physics; Play; Population; Prevention approach; Preventive measure; Process; Research; Research Personnel; Resources; Role; Science; Scientist; Sense Organs; Shapes; Signal Pathway; Signal Transduction; Structure; Students; Thinking; Time; Tissue Engineering; Tissues; Training; Translations; Update; Work; career; cell type; craniofacial; craniofacial development; craniofacial disorder; craniofacial repair; craniofacial structure; craniofacial tissue; educational atmosphere; functional genomics; graduate student; imaging modality; improved; insight; interdisciplinary approach; medical specialties; meetings; novel strategies; novel therapeutic intervention; oral tissue; organ growth; posters; programs; regenerative; repaired; research study; stem cell biology; stem cell differentiation; symposium; tissue regeneration; tissue repair; tissue stem cells

Project Summary The ultimate aim of craniofacial research is to understand the causes underlying craniofacial malformations and to develop diagnostics and therapies for these disorders and for repair of craniofacial tissues. An in-depth, interdisciplinary understanding of developmental biology, disease processes and tissue repair provides an essential foundation for insights into the mechanisms of craniofacial morphogenesis and regeneration and the subsequent translation of scientific outcomes to the clinical management of disorders of the head and face. Such in-depth work probes the cellular events and molecular switches that control tissue patterning and repair and the morphogenetic processes that shape craniofacial tissues and organs. Contemporary studies of the development of the vertebrate head and face take a multidisciplinary approach combining developmental biology with functional genomics, biochemistry, biophysics, molecular biology and cellular biology. As in other fields of developmental biology research, the study of craniofacial development utilises a range of vertebrate species, including those that are not commonly used for laboratory studies. Collectively, these provide a range of experimental models for investigating the molecular and cellular mechanisms underpinning the morphogenesis of craniofacial structures and their associated organs in health and diseases, as well as offering insights into the evolutionary forces and environmental factors driving the diversity of form and function of these structures. Research in craniofacial development is a key element of the discipline of developmental and cell biology and aligns well with the scope of several journals. The scientific program will highlight how interdisciplinary research can push boundaries in our understanding of craniofacial research, through talks investigating the physics and chemistry of craniofacial biology. Such approaches help researchers address how craniofacial cell populations work together (integration) and how the surrounding environment impacts on form. This will be accompanied by discussions on how these processes drive tissue diversity and the form shaping process, and how distinctive features of the vertebrate head have evolved. Invited presentations by leading researchers will discuss new findings in craniofacial morphogenesis and repair, with specific focus on the role that mechanics plays in shaping development. The meeting will also feature sessions on cell signalling, clinical genetics, sense organs, development of new animal models of craniofacial disorders, and on the applications of tissue engineering strategies for regenerative craniofacial tissue repair. The programme will bring together researchers of diverse expertise to foster stimulating discussions and productive collaborations across different fields in a collegial atmosphere.

项目摘要 颅面研究的最终目的是了解颅面的潜在原因。 并开发这些疾病的诊断和治疗方法以及修复头面部组织。 对发育生物学、疾病过程和组织修复有深入的、跨学科的理解 为深入了解颅面形态发生和发育的机制提供了重要的基础 再生和随后将科学成果转化为精神障碍的临床治疗 头和脸。这种深入的工作探索控制组织的细胞事件和分子开关 图案化和修复以及形成头面部组织和器官的形态发生过程。 脊椎动物头部和面部发育的当代研究采取了多学科的方式 发育生物学与功能基因组学、生物化学、生物物理学、分子生物学相结合的方法 生物学和细胞生物学。与发育生物学研究的其他领域一样，颅面部的研究 开发利用了一系列脊椎动物物种，包括那些不常用于实验室的物种 学习。总的来说，这些都为研究分子和细胞提供了一系列的实验模型。 健康人颅面结构及其相关器官形态发生的机制 以及对推动人类进化的力量和环境因素的洞察 这些结构的形式和功能的多样性。颅面发育的研究是 这是发育和细胞生物学的一门学科，与几种期刊的范围很好地吻合。 科学计划将突出跨学科研究如何在我们的 从头面部的物理和化学研究谈对颅面研究的认识 生物学。这些方法帮助研究人员解决头面部细胞群体如何协同工作(整合)。 以及周围环境对形态的影响。与此同时，还将讨论如何实现这些目标 过程驱动组织多样性和形状形成过程，以及脊椎动物的独特特征 头部已经进化了。主要研究人员的应邀演讲将讨论颅面外科的新发现 形态发生和修复，特别关注力学在形成发育中所起的作用。这个 会议还将包括细胞信号、临床遗传学、感官、新动物发育等方面的会议 颅面部疾病模型及组织工程策略在再生中的应用 头面部组织修复。该计划将汇集具有不同专业知识的研究人员，以促进 在大学氛围中，在不同领域进行讨论和富有成效的合作。