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Bioengineered Composite Alveolar Bone-Tooth Constructs for Tooth Regeneration

用于牙齿再生的生物工程复合牙槽骨牙齿结构

基本信息

批准号：
9975806
负责人：
PAMELA C YELICK
金额：
$ 71.24万
依托单位：
TUFTS UNIVERSITY BOSTON
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9975806
关键词：
3-Dimensional Accidents Address Adult Affect Age Alveolar Alveolar Bone Loss Animal Model Athletic Injuries Autologous Biomedical Engineering Biomimetics Blood Bone Regeneration Bone Resorption Bone Tissue Cells Child Clinical Trials Complex Congenital Abnormality Craniofacial Abnormalities Data Defect Dental Dental Implants Dentistry Dentition Development Disease Excision Exhibits Extracellular Matrix Family suidae Gelatin Genetic Goals Growth Factor Harvest Health Health Priorities Human Hydrogels Immune system Implant Individual Injury Interdisciplinary Study Jaw Knowledge Live Birth Malignant Neoplasms Mandible Maxilla Methacrylates Methods Military Personnel Minerals Mission Modeling Morbidity - disease rate National Institute of Dental and Craniofacial Research Natural regeneration Nerve Operative Surgical Procedures Oryctolagus cuniculus Persons Population Property Public Health Publishing Quality of life Regenerative Medicine Replacement Therapy Reporting Research Signal Pathway Silk Site Source Techniques Technology Time Tissue Engineering Tissues Tooth Germ Tooth Loss Tooth Tissue Tooth regeneration Tooth structure United States United States National Institutes of Health aging population alveolar bone base bioprinting bone cleft lip and palate clinically relevant craniofacial craniofacial complex craniofacial development craniofacial repair design healing improved innovation malignant mouth neoplasm novel novel strategies oral surgery specialty regenerative regenerative therapy repaired scaffold skeletal tissue support frame

项目摘要

Project Summary/Abstract The coordinated development of craniofacial jaw bones and teeth are the result of a complex interplay between a surprisingly large and growing number of tissues - including blood and vasculature, and nerves – combined with the immune system, and a multitude of growth factor signaling pathways. Although knowledge of signaling pathways resulting in human mineralized tissue development has improved over the past few decades, detailed knowledge and understanding of how to regenerate human mineralized tissues in a functional and timely manner remains elusive – particularly with respect to the craniofacial complex and teeth. Here we propose novel strategies to effectively and coordinately regenerate alveolar jaw bone and tooth tissues, using three dimensional tissue engineering strategies. The objectives of the proposed studies, which build on our prior published reports, are to characterize two potential models for biomimetic three dimensional alveolar bone-tooth constructs: 1) natural decellularized tooth bud extracellular matrix scaffolds; and 2) Gelatin Methacrylate (GelMA) hydrogel scaffolds. Our published expertise in in the field of regenerative dentistry, mineralized tissue development and disease, strong preliminary data, and team of developmental biologists, clinicians and bioengineers supports our ability to accomplish the proposed Aims. We anticipate that the completion of the proposed studies will result in significantly improved knowledge and understanding of new methods to repair craniofacial defects caused by a variety of insults. The significance of the proposed studies and relevance to public health includes the facts that skeletal and craniofacial defects occur in as many as 1 in 700 live births in the United States alone, and that over a quarter of a million Maxillofacial surgeries were performed in 2014, including oral cancer resections. In addition, injuries to the craniofacial complex that include teeth are increasingly common due to accidents and sports injuries, and particularly in the battlefield where they represent up to 20% of injuries. As such, the proposed studies will make a significant contribution towards improved quality of life of both civilian and military populations.

项目总结/文摘