2022 Craniofacial Morphogenesis and Tissue Regeneration Gordon Research Conference and Gordon Research Seminar

项目摘要 颅面研究的目标是更好地了解正常发育、颅面的潜在原因 以及如何最好地开发诊断和治疗方法来修复头面部组织。深入探讨 对发育生物学、颅面部疾病过程和组织修复的跨学科理解可以 提供对调节颅面形态发生和再生的机制的基本见解，以及 翻译科学成果以有效治疗影响头部和大脑的各种临床疾病 脸。这种深入的理解需要详细的细胞事件和分子信号的知识， 控制头面部组织图案化、发育和修复，以及形成的形态发生过程 头面部组织和器官。 脊椎动物颅面复合体的当代发育研究采用多学科 方法包括发育生物学、功能基因组学、生物医学工程、生物物理学和 分子和细胞生物学。颅面发育的研究利用了广泛的脊椎动物和 无脊椎动物模型，它们共同提供了各种实验方法来研究分子 以及健康和疾病中颅面结构形态发生的细胞机制。 这些模型还提供了对推动生物多样性的进化力量和环境因素的洞察 颅面形态和功能。因此，颅面发育的研究是发育的一个重要学科。 和细胞生物学，并与著名的同行评议期刊的范围很好地一致。 这里提出的2022年颅面形态发生和组织再生GRC/GRS将突出显示 跨学科的研究正在迅速扩大我们对颅面发育和组织的理解 通过探讨分子和生物力学信号调控的整合来实现再生 头面部发育。这种跨学科的方法正被用来解释如何发展 头面部组织和它们的环境相互作用，创造出头面部的形态和功能。建议数 演讲将伴随着广泛的讨论，讨论这些过程如何推动 头面部结构，以及脊椎动物头部的许多明显特征已经进化。 新老研究人员的应邀演讲将讨论颅面外科的新发现 形态发生和组织再生，特别关注机械和生物电信号的作用 在颅面发育和组织再生方面。会议还将举行关于小区信令的会议， 临床遗传学、感觉器官、新的头面部疾病动物模型和新的组织工程 颅面再生性组织修复策略。该计划旨在促进BASIC 科学研究人员、临床科学家、生物医学工程师和不同专业的进化生物学家， 以便在高度合作的气氛中促进富有启发性的讨论和富有成效的新合作。

Project Summary Goals of craniofacial research are to better understand normal development, the causes underlying craniofacial malformations, and how best to develop diagnostics and therapies to repair craniofacial tissues. In-depth interdisciplinary understanding of developmental biology, craniofacial disease processes and tissue repair can provide essential insight into mechanisms regulating craniofacial morphogenesis and regeneration, and the translation of scientific outcomes to effectively treat the wide variety of clinical disorders affecting the head and face. Such in-depth understanding requires detailed knowledge of the cellular events and molecular signals that control craniofacial tissue patterning, development and repair, and the morphogenetic processes that shape craniofacial tissues and organs. Contemporary developmental studies of the vertebrate craniofacial complex employ multidisciplinary approaches including developmental biology, functional genomics, biomedical engineering, biophysics, and molecular and cellular biology. The study of craniofacial development utilises a wide range of vertebrate and invertebrate models, which collectively provide a variety of experimental approaches to investigate the molecular and cellular mechanisms underlying the morphogenesis of craniofacial structures in both health and disease. These models also offer insight into the evolutionary forces and environmental factors driving the diversity of craniofacial form and function. As such, research in craniofacial development is a key discipline of developmental and cellular biology and aligns well with the scope of prominent peer-reviewed journals. The 2022 Craniofacial Morphogenesis and Tissue Regeneration GRC/GRS proposed here will highlight how interdisciplinary research is rapidly expanding our understanding of craniofacial development and tissue regeneration through talks investigating the integration of molecular and biomechanical signals regulating craniofacial development. Such interdisciplinary approaches are being used to elucidate how developing craniofacial tissues and their environment interact to create craniofacial form and function. The proposed presentations will be accompanied by extensive discussions on how these processes drive the diversity of craniofacial structures, and how many distinctive features of the vertebrate head have evolved. Invited presentations by new and established researchers will discuss new findings in craniofacial morphogenesis and tissue regeneration, with specific focus on the role of mechanical and bioelectric signaling in craniofacial development and tissue regeneration. The meeting will also feature sessions on cell signalling, clinical genetics, sense organs, new animal models of craniofacial disorders, and on novel tissue engineering strategies for regenerative craniofacial tissue repair. The program is designed to promote interactions of basic science researchers, clinician scientists, biomedical engineers and evolutionary biologists of diverse expertise, in order to foster stimulating discussions and productive new collaborations in a highly collegial atmosphere.