2022 Craniofacial Morphogenesis and Tissue Regeneration Gordon Research Conference and Gordon Research Seminar

2022颅面形态发生与组织再生戈登研究会议暨戈登研究研讨会

• 批准号: 10388749
• 负责人: PAMELA C YELICK
• 金额: $ 2.35万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10388749
• 关键词: Adult; Affect; Animal Model; Automobile Driving; Basic Science; Biocompatible Materials; Biology; Biomechanics; Biomedical Engineering; Biophysics; Cellular biology; Clinic; Clinical; Clinical Sciences; Collaborations; Communities; Complex; Computational Biology; Congenital Abnormality; Craniofacial Abnormalities; Data Science; Dental; Dentistry; Development; Developmental Biology; Diagnostic; Discipline; Disease; Dysmorphology; Environment; Environmental Risk Factor; Esthetics; Event; Face; FaceBase; Feedback; Fostering; Future; Genetic; Genetic Determinism; Genetic Diseases; Goals; Head; Health; Homeostasis; Human Genetics; Immunology; Interdisciplinary Study; International; Invertebrates; Journals; Knowledge; Learning; Mechanics; Medical Genetics; Methods; Modeling; Molecular; Molecular and Cellular Biology; Morphogenesis; National Institute of Dental and Craniofacial Research; Natural regeneration; Operative Surgical Procedures; Oral; Organ; Outcome; Participant; Pattern; Peer Review; Prevention; Prevention strategy; Process; Regenerative Medicine; Research; Research Personnel; Resolution; Resources; Role; Scientific Advances and Accomplishments; Scientist; Sense Organs; Shapes; Signal Pathway; Signal Transduction; Students; Tissue Engineering; Tissues; Training; Translations; United States National Institutes of Health; Work; bioelectricity; biomechanical engineering; career; craniofacial; craniofacial complex; craniofacial development; craniofacial disorder; craniofacial repair; craniofacial structure; craniofacial tissue; design; educational atmosphere; functional genomics; graduate student; improved; in vivo imaging; innovation; insight; interdisciplinary approach; medical specialties; meetings; novel; novel strategies; novel therapeutic intervention; posters; programs; regenerative; regenerative approach; repaired; response to injury; stem cell biology; stem cell differentiation; stem cells; symposium; tissue regeneration; tissue repair

Project Summary Goals of craniofacial research are to better understand normal development, the causes underlying craniofacial malformations, and how best to develop diagnostics and therapies to repair craniofacial tissues. In-depth interdisciplinary understanding of developmental biology, craniofacial disease processes and tissue repair can provide essential insight into mechanisms regulating craniofacial morphogenesis and regeneration, and the translation of scientific outcomes to effectively treat the wide variety of clinical disorders affecting the head and face. Such in-depth understanding requires detailed knowledge of the cellular events and molecular signals that control craniofacial tissue patterning, development and repair, and the morphogenetic processes that shape craniofacial tissues and organs. Contemporary developmental studies of the vertebrate craniofacial complex employ multidisciplinary approaches including developmental biology, functional genomics, biomedical engineering, biophysics, and molecular and cellular biology. The study of craniofacial development utilises a wide range of vertebrate and invertebrate models, which collectively provide a variety of experimental approaches to investigate the molecular and cellular mechanisms underlying the morphogenesis of craniofacial structures in both health and disease. These models also offer insight into the evolutionary forces and environmental factors driving the diversity of craniofacial form and function. As such, research in craniofacial development is a key discipline of developmental and cellular biology and aligns well with the scope of prominent peer-reviewed journals. The 2022 Craniofacial Morphogenesis and Tissue Regeneration GRC/GRS proposed here will highlight how interdisciplinary research is rapidly expanding our understanding of craniofacial development and tissue regeneration through talks investigating the integration of molecular and biomechanical signals regulating craniofacial development. Such interdisciplinary approaches are being used to elucidate how developing craniofacial tissues and their environment interact to create craniofacial form and function. The proposed presentations will be accompanied by extensive discussions on how these processes drive the diversity of craniofacial structures, and how many distinctive features of the vertebrate head have evolved. Invited presentations by new and established researchers will discuss new findings in craniofacial morphogenesis and tissue regeneration, with specific focus on the role of mechanical and bioelectric signaling in craniofacial development and tissue regeneration. The meeting will also feature sessions on cell signalling, clinical genetics, sense organs, new animal models of craniofacial disorders, and on novel tissue engineering strategies for regenerative craniofacial tissue repair. The program is designed to promote interactions of basic science researchers, clinician scientists, biomedical engineers and evolutionary biologists of diverse expertise, in order to foster stimulating discussions and productive new collaborations in a highly collegial atmosphere.

项目摘要 颅面研究的目标是更好地了解正常的发展，颅面的原因 畸形，以及如何最好地开发诊断和治疗来修复颅面组织。深入 对发育生物学、颅面疾病过程和组织修复的跨学科理解可以 提供了重要的洞察机制调节颅面形态发生和再生， 科学成果的转化，以有效地治疗各种影响头部的临床疾病， 脸上这种深入的理解需要详细了解细胞事件和分子信号， 控制颅面组织的模式，发育和修复，以及形状形成的形态发生过程 颅面组织和器官 当代脊椎动物颅面复合体的发育研究采用了多学科的方法， 方法包括发育生物学，功能基因组学，生物医学工程，生物物理学， 分子和细胞生物学。颅面发育的研究利用了广泛的脊椎动物和 无脊椎动物模型，共同提供了各种实验方法来研究分子 以及健康和疾病中颅面结构形态发生的细胞机制。 这些模型还提供了对进化力量和环境因素的深入了解，这些因素推动了生物多样性的发展。 颅面形态和功能因此，颅面发育的研究是发育学的一个关键学科。 和细胞生物学，并与著名的同行评审期刊的范围保持一致。 这里提出的2022年颅面形态发生和组织再生GRC/GRS将强调如何 跨学科的研究正在迅速扩展我们对颅面发育和组织的理解 再生通过会谈调查分子和生物力学信号调节的整合 颅面发育这种跨学科的方法正在被用来阐明如何发展 颅面组织和它们的环境相互作用以产生颅面形态和功能。拟议 演讲将伴随着关于这些过程如何推动多样性的广泛讨论， 颅面结构，以及脊椎动物头部进化出了多少独特的特征。 新的和建立的研究人员邀请演讲将讨论颅面的新发现， 形态发生和组织再生，特别关注机械和生物电信号的作用 在颅面发育和组织再生中的作用会议还将讨论细胞信号， 临床遗传学，感觉器官，颅面疾病的新动物模型，以及新的组织工程 再生颅面组织修复的策略。该计划旨在促进基本 科学研究人员、临床科学家、生物医学工程师和具有不同专业知识的进化生物学家， 以便在高度学院式的气氛中促进富有启发性的讨论和富有成效的新合作。