2020 Oxygen Radicals Gordon Research Conference (GRC) and Gordon Research Seminar (GRS)

项目摘要 这项会议拨款提案寻求为戈登研究会议(GRC)提供资金，会议主题是氧自由基： 化学反应、代谢和治疗发展机会将在加利福尼亚州文图拉举行 2020年2月2日至7日，与戈登研究研讨会(GRS)联合举办，由两名 实习生(谢丽尔·范·德·韦特林和Rhea Bovee)，将于2020年2月1日至2日在GRC之前举行 在同一地点。我们提出了一个令人兴奋的计划，将不同领域的氧化剂研究结合在一起， 将最新发现的新氧化剂种类与方法学进步、生物学研究、 细胞器功能障碍和新陈代谢，以及衰老，以及全会和圆桌讨论，重点是氧化还原- 临床开发中的基础药物。该计划包括资深科学家(主旨演讲)，如 是初级和职业生涯中期的科学家，我们有10个机会从提交的摘要中邀请演讲。扬声器 来自学术界、工业界和美国国立卫生研究院，代表19个国家，并将在 九场会议：主旨会议一：氧自由基：将化学与生物和医学联系起来； 从能源工厂到代谢调节器的线粒体；干细胞功能中的氧自由基， 衰老和衰老；翻译中的氧化还原：治疗的障碍和前进方向；内质 网状氧化还原控制疾病中的蛋白平衡和失调；死亡中的反应性脂类，内稳态和 作为治疗药物：铁性下垂及其他；氧化还原传感器、探头和诊断的进展；氧自由基 新陈代谢；第二次主旨会议：氧自由基研究的技术进展；机会和 挑战。会议的其他亮点包括权力之小时和女性在Twitter上的代表 #REDOXWOMEN并保证至少40%的演讲者或讨论负责人是女性。我们会 有突出海报的电梯推介会议，以及实习生提出第一个问题的政策。我们将热烈欢迎 餐桌和社交活动将包括新的参与者，并延续铁螺栓奖的传统 最值得注意的评论。总体而言，这一计划将确保一个充满活力和大学氛围的分享 氧自由基研究的最新发现，氧自由基与疾病和衰老的关系以及可能的途径 治疗方面的发展。

Project Summary This conference grant proposal seeks funds for a Gordon Research Conference (GRC) on Oxygen Radicals: Chemical Reactivity, Metabolism, and Opportunities for Therapeutic Development to be held in Ventura CA February 2-7, 2020, in conjunction with a Gordon Research Seminar (GRS) for trainees, organized by two trainees (Cheryl van de Wetering, and Rhea Bovee), to be held immediate prior to the GRC, February 1-2, 2020 at the same location. We present an exciting program that brings together diverse fields of oxidant research, integrating recent discoveries of new oxidant species, with methodological advances, studies of biology, organelle dysfunction and metabolism, and aging, and plenary and round table discussions focusing on redox- based drugs in clinical development. The program includes senior scientists (giving the keynote lectures), as was as junior and mid-career scientists, and we have 10 slots for invited talks from submitted abstracts. Speakers are from academia, industry and the NIH, represent 19 countries and will be sharing their latest discoveries in nine sessions: Keynote session I: Oxygen Radicals: connecting chemistry with biology and medicine; Mitochondria from energy power houses to metabolite regulators; Oxygen radicals in stem cell function, senescence and aging; Redox in translation: Hurdles and ways forward toward therapeutics; Endoplasmic reticulum-redox control of proteostasis and dysregulation in disease; Reactive lipids in death, homeostasis and as therapeutics: Ferroptosis, and beyond; Advances in redox sensors, probes, and diagnostics; Oxygen radicals in metabolism; Keynote session II: Technical advances in the study of oxygen radicals; opportunities and challenges. Other conference highlights are the power hour and representation by women with a twitter feed #REDOXWOMEN and assurance that at least 40% of all presenters or discussion leaders are women. We will have elevator pitch sessions to highlight posters, and a policy of first questions by trainees. We will have welcome tables and social events to be inclusive of new attendees and continue the tradition of the Iron Bolt Award for the most notable comment. Collectively, this program will ensure a vibrant and collegial atmosphere to share the top discoveries in research on oxygen radicals, their involvement in disease and aging and potential avenues for therapeutic development.