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Development of clinical decision tools for management of diarrhea of children in high and low resource settings

Development of clinical decision tools for management of diarrhea of children in high and low resource settings
开发资源丰富和匮乏环境下儿童腹泻管理的临床决策工具
批准号:
9912093
负责人:
Daniel Ted Leung
金额:
$39.72万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-05-08 至 2022-04-30

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中文摘要
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摘要
英文摘要
Abstract Diarrheal diseases are the among the leading cause of death in children worldwide, most of which occur in low-income countries. In high-income countries, pediatric diarrhea remains a major utilization of healthcare resources. Treatment of diarrhea is mostly empiric, with antibiotic use mostly based on clinical suspicion for bacterial causes. However, the majority of cases of diarrhea do not benefit from antibiotic use, and inappropriate use leads to toxicity and resistance. Furthermore, despite the increasing availability of rapid molecular testing, there is little data to base a decision of whom or when to test. Our overarching goal is to develop and validate clinical decision tools for management of diarrheal illnesses in children of both high and low resource settings. We will utilize prospectively-collected data from two recently-completed multicenter cohort studies of pediatric diarrhea. These studies feature extensive etiologic testing, well-characterized clinical elements, and longitudinal outcome data. We have assembled a team with expertise in pediatric diarrhea, clinical prediction rules, and machine learning methods. In Aim 1, we will use domestic data to develop and validate: a) a score for bacterial etiology, and b) a score for which patients are likely to benefit from further testing. We will derive the scores using data from IMPACT, an NIH-sponsored study of 1200 children from 5 US Emergency Departments, and validate using electronic health records from the Utah Intermountain Health System. In Aim 2, we will use international data to develop and validate: a) a diagnostic score for bacterial etiology, and b) a prognostic score for risk stratification of children who go on to poor outcomes. We will derive the scores using data from GEMS, a study of over 9400 children across 7 low-resource countries, and validate using VIDA study of children in 3 African countries. Completion of the Aims will result in the availability of a number of clinical tools that healthcare workers worldwide can use for evidence-based care of children with diarrhea.
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Mentoring patient-oriented researchers in pediatric diarrhea
  • 批准号:
    10591728
  • 项目类别:
  • 资助金额:
    $17.19万
  • 财政年份:
    2023
  • 负责人:
    Daniel Ted Leung
  • 依托单位:
Development of clinical decision tools for management of diarrhea of children in high and low resource settings
  • 批准号:
    10522523
  • 项目类别:
  • 资助金额:
    $46.59万
  • 财政年份:
    2018
  • 负责人:
    Daniel Ted Leung
  • 依托单位:
Estimating Cholera Burden with Cross-sectional Immunologic Data
  • 批准号:
    10132972
  • 项目类别:
  • 资助金额:
    $66.34万
  • 财政年份:
    2018
  • 负责人:
    Daniel Ted Leung
  • 依托单位:
Estimating Cholera Burden with Cross-sectional Immunologic Data
  • 批准号:
    9912094
  • 项目类别:
  • 资助金额:
    $66.77万
  • 财政年份:
    2018
  • 负责人:
    Daniel Ted Leung
  • 依托单位:
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