Translational Vision Science Research at Oregon Health & Science University

项目摘要 这一建议的前提是，培养下一代视觉科学家的基本翻译 从科学研究到临床和公共卫生干预将是推动该领域发展的关键。基本 科学和技术正在以前所未有的速度进步。然而，我们的观察表明， 眼科医生通常缺乏背景知识，无法理解最近的基础和临床研究 研究结果可能适用于他们的实践，视觉科学家往往缺乏足够的视角来识别差距 来指导他们的研究。本申请提出更新成功的T32翻译酶。 视觉研究培训计划，为基础或应用科学博士前培训计划的学生提供，或 俄勒冈州健康与科学大学（OHSU）博士后研究员。总体目标是让个人做好准备 通过教学教育和强化辅导， 在多学科环境中的研究经验。OHSU的视觉研究和培训环境 是高度合作和跨学科的，在翻译研究从强大的方案支持， 在基因治疗、分子遗传学、药物开发、临床试验等领域， 眼科成像和生物医学信息学。该大学在临床医学方面拥有顶级的教育项目。 眼科和基础视觉科学，并一直在全国排名前10位的NEI支持 research.该计划填补了教育的一个重要空白，因为OHSU是少数几个主要的学术机构之一。 医学中心在太平洋西北部，但没有其他计划，以支持教学培训的视觉 这里的科学研究。我们将继续利用OHSU现有的基础设施， 博士和博士后学员受益于并有助于这项研究和教育 环境自2013年以来，我们已经支持了13名学员（包括2名代表不足的少数民族和3名 与导师一起在主要期刊上发表了60篇同行评审论文。我们特别 我建议继续为3名博士前和1名博士后培训生提供T32课程，这些课程将被整合 与正在进行的研究和现有的OHSU基础科学研究生课程。培训包括六个关键 组成部分：（1）与导师和合作者的研究项目，（2）涵盖基础知识的教学课程 基础，临床和转化视觉科学，（3）每月两次的视觉研究研讨会，讨论 学员和教员持续进行研究，沿着每周半天的教学会议，（4）全机构 教育和职业发展活动，（5）赠款导师计划，以教授和支持受训者， 他们申请自己的独立资助，以及（6）接受负责任地开展研究的培训。我们认为 该计划将继续提供一个临床的观点，以学员与现有的背景，在基本 科学OHSU是一个通过T32计划进行基础和临床研究严格培训的环境， 为一代年轻研究人员提供优化翻译视觉研究的工具。

PROJECT SUMMARY The premise of this proposal is that training the next generation of vision scientists in translation of basic science research to clinical and public health interventions will be critical toward advancing the field. Basic scientific and technological advances are occurring at an unprecedented pace. However, our observation has been that ophthalmologists often lack the background to understand how recent basic and clinical research findings may be applied to their practices, and visual scientists often lack adequate perspective to identify gaps in clinical knowledge to guide their research. This application proposes to renew a successful T32 translational vision research training program for students in pre-doctoral training programs in basic or applied science, or postdoctoral fellows at Oregon Health & Science University (OHSU). The overall goal is to prepare individuals for successful academic careers in vision science research through didactic education and intensive mentored research experience in a multidisciplinary environment. The vision research and training environment at OHSU is highly collaborative and interdisciplinary, with strong programmatic support in translation of research from bench to bedside in areas such as gene therapy, molecular genetics, drug development, clinical trials, ophthalmic imaging, and biomedical informatics. The university has top educational programs in clinical ophthalmology and basic visual science, and is consistently ranked in the top 10 nationally in NEI-supported research. This program fills an important gap in education because OHSU is one of the few major academic medical centers in the Pacific Northwest, yet there are no other programs to support didactic training in visual science research here. We will continue to leverage the existing infrastructure at OHSU to allow more pre- doctoral and post-doctoral trainees to benefit from and contribute toward this research and educational environment. Since 2013, we have supported 13 trainees (including 2 under-represented minorities and 3 women) who have published 60 peer-reviewed papers with their mentors in leading journals. Specifically, we propose to continue this T32 program for 3 pre-doctoral and 1 post-doctoral trainee, which will be integrated with ongoing research and existing OHSU graduate programs in basic science. Training consists of six key components: (1) research projects with mentors and collaborators, (2) a didactic course covering fundamentals of basic, clinical, and translational vision science, (3) twice-monthly vision research seminars for discussion of ongoing research by trainees and faculty, along with weekly half-day teaching sessions, (4) institution-wide education and career development activities, (5) a grant mentorship program to teach and support trainees as they apply for their own, independent funding and (6) training in responsible conduct of research. We believe this program will continue to provide a clinical perspective to trainees with existing backgrounds in basic science. OHSU is a setting where rigorous training in basic and clinical research through this T32 program will provide a generation of young researchers with the tools to optimize translational vision research.