Translational Vision Science Research at Oregon Health & Science University

项目总结 这一建议的前提是培养下一代视觉科学家的基本翻译能力 对临床和公共卫生干预措施的科学研究将是推动该领域发展的关键。基本信息 科技进步正以前所未有的速度发展。然而，根据我们的观察， 眼科医生往往缺乏背景知识来理解最近的基础和临床研究 这些发现可能会应用到他们的实践中，而视觉科学家往往缺乏足够的视角来识别差距 在临床知识上指导他们的研究。此应用程序建议续订成功的T32翻译 为基础或应用科学博士前培训计划的学生提供视力研究培训计划，或 俄勒冈健康科学大学(OHSU)博士后研究员。总体目标是让个人做好准备 通过授课教育和强化指导在视觉科学研究领域取得成功的学术生涯 在多学科环境中的研究经验。OHSU的视觉研究和培训环境 高度协作和跨学科，并在翻译研究方面提供强有力的方案支持 在基因治疗、分子遗传学、药物开发、临床试验、 眼科成像和生物医学信息学。这所大学有顶尖的临床教育项目。 眼科学和基础视觉科学，并在NEI支持的全国排名前十 研究。该项目填补了教育领域的一个重要空白，因为OHSU是为数不多的主要学术机构之一 太平洋西北部的医疗中心，但没有其他计划来支持视觉教学培训 这里是科学研究中心。我们将继续利用OHSU的现有基础设施，允许更多的预 博士后和博士后实习生从这项研究和教育中受益并做出贡献 环境。自2013年以来，我们支持了13名受训人员(包括2名人数不足的少数族裔和3名 女性)，她们与导师一起在主要期刊上发表了60篇同行评议的论文。具体来说，我们 建议继续为3名博士后和1名博士后实习生提供T32项目，该项目将整合 正在进行的研究和OHSU现有的基础科学研究生课程。培训包括六个关键 组成部分：(1)与导师和合作者合作的研究项目，(2)包括基础知识的教学课程 基础、临床和转化性视觉科学；(3)每月两次的视觉研究研讨会，讨论 实习生和教职员工正在进行的研究，以及每周半天的教学会议，(4)机构范围 教育和职业发展活动，(5)赠款指导方案，教授和支持受训人员 他们申请自己的独立资金和(6)负责任的研究行为培训。我们相信 该计划将继续为具有基础知识背景的学员提供临床视角。 科学。OHSU是一个通过T32计划在基础和临床研究方面进行严格培训的环境 为新一代年轻研究人员提供优化翻译视觉研究的工具。

PROJECT SUMMARY The premise of this proposal is that training the next generation of vision scientists in translation of basic science research to clinical and public health interventions will be critical toward advancing the field. Basic scientific and technological advances are occurring at an unprecedented pace. However, our observation has been that ophthalmologists often lack the background to understand how recent basic and clinical research findings may be applied to their practices, and visual scientists often lack adequate perspective to identify gaps in clinical knowledge to guide their research. This application proposes to renew a successful T32 translational vision research training program for students in pre-doctoral training programs in basic or applied science, or postdoctoral fellows at Oregon Health & Science University (OHSU). The overall goal is to prepare individuals for successful academic careers in vision science research through didactic education and intensive mentored research experience in a multidisciplinary environment. The vision research and training environment at OHSU is highly collaborative and interdisciplinary, with strong programmatic support in translation of research from bench to bedside in areas such as gene therapy, molecular genetics, drug development, clinical trials, ophthalmic imaging, and biomedical informatics. The university has top educational programs in clinical ophthalmology and basic visual science, and is consistently ranked in the top 10 nationally in NEI-supported research. This program fills an important gap in education because OHSU is one of the few major academic medical centers in the Pacific Northwest, yet there are no other programs to support didactic training in visual science research here. We will continue to leverage the existing infrastructure at OHSU to allow more pre- doctoral and post-doctoral trainees to benefit from and contribute toward this research and educational environment. Since 2013, we have supported 13 trainees (including 2 under-represented minorities and 3 women) who have published 60 peer-reviewed papers with their mentors in leading journals. Specifically, we propose to continue this T32 program for 3 pre-doctoral and 1 post-doctoral trainee, which will be integrated with ongoing research and existing OHSU graduate programs in basic science. Training consists of six key components: (1) research projects with mentors and collaborators, (2) a didactic course covering fundamentals of basic, clinical, and translational vision science, (3) twice-monthly vision research seminars for discussion of ongoing research by trainees and faculty, along with weekly half-day teaching sessions, (4) institution-wide education and career development activities, (5) a grant mentorship program to teach and support trainees as they apply for their own, independent funding and (6) training in responsible conduct of research. We believe this program will continue to provide a clinical perspective to trainees with existing backgrounds in basic science. OHSU is a setting where rigorous training in basic and clinical research through this T32 program will provide a generation of young researchers with the tools to optimize translational vision research.