IGF::OT::IGF ATHEROSCLEROSIS IN RISK COMMUNITIES - COORDINATING CENTER - CORE STUDY OPERATIONS

IGF::OT::IGF 动脉粥样硬化风险社区 - 协调中心 - 核心研究运作

• 批准号: 9915720
• 负责人: DAVID COUPER
• 金额: $ 263.31万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-11-15 至 2019-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915720
• 关键词: Abdomen; Address; Adult; African American; Ancillary Study; Ankle; Atherosclerosis; Atherosclerosis Risk in Communities; Behavioral; Behavioral Genetics; Carotid Arteries; Characteristics; Clinical; Cohort Studies; Collaborations; Communities; Contracts; Coronary heart disease; County; Data; Data Collection; Data Set; Development; Disease; Electronic Health Record; Event; Fostering; Functional disorder; Funding; Genetic; Geographic Locations; Goals; Grant; Heart failure; Hemostatic Agents; Laboratories; Measurement; Monitor; Myocardial Infarction; Natural History; Participant; Photography; Policies; Process; Prospective cohort study; Psychosocial Factor; Publications; Research Personnel; Retinal; Risk Factors; Risk Marker; Sampling; Structure of popliteal artery; Subgroup; Technology; Testing; Ultrasonography; United States National Institutes of Health; Washington; aged; base; caucasian American; clinical development; clinical predictors; cognitive function; cohort; data sharing; follow-up; indexing; middle age; mortality; operation; psychologic; recruit; rural setting; socioeconomics; suburb; trend

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998), with a fifth clinical exam in 2011-2013, providing a rich set of data on physical, behavioral, genetic, and psychosocial factors. Since 1988, the cohort has been contacted annually and in 2011 semiannual follow-up was initiated. Findings have been presented in over 1,400 publications as of 2014. Participants were examined for evidence of subclinical atherosclerosis using B-mode ultrasound in carotid and popliteal arteries, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, and hemostatic factors; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, and environmental characteristics; and genetic factors. Examinations included a variety of components, with a grant-funded detailed cognitive function testing component added in the most recent exam.

社区动脉粥样硬化风险研究（ARIC）于1985年启动，由两部分组成：基于社区的监测和前瞻性队列研究。社区监测旨在监测美国四个社区的住院心肌梗死（MI）、致死性冠心病（CHD）趋势：福赛斯县，NC;杰克逊，MS;明尼阿波利斯郊区，MN;和华盛顿县，MD。2005年增加了对住院心力衰竭（HF）事件的监测。选择这些社区是为了提供城市、郊区和农村四（4）个地理位置的死亡率数据。该队列研究旨在调查来自同一社区的中年白色或非洲裔美国人中动脉粥样硬化的危险因素和自然史以及临床动脉粥样硬化的发展。这项研究招募了15,792名最初年龄在45-64岁之间的白色或非洲裔美国人参与者，并在研究的前十年接受了三年一次的临床检查（1987-1989，1990-1992，1993-1995和1996-1998），在2011-2013年进行了第五次临床检查，提供了关于身体，行为，遗传和心理社会因素的丰富数据。自1988年以来，每年联系该队列，并于2011年开始半年随访。截至2014年，研究结果已发表在1,400多篇出版物中。通过颈动脉和腘动脉B超、踝臂指数测量和视网膜摄影检查参与者是否存在亚临床动脉粥样硬化的证据，并在亚组中检查腹主动脉CT和止血因素;确定和推定的实验室风险标志物;社会经济、心理、行为和环境特征;以及遗传因素。考试包括各种组成部分，在最近的考试中增加了由赠款资助的详细认知功能测试组成部分。