TAS::75 0872::TAS ARIC DATA COORDINATING CENTER

塔斯马尼亚州::75 0872::塔斯马尼亚州阿里克数据协调中心

• 批准号: 9004266
• 负责人: DAVID COUPER
• 金额: $ 229.61万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-11-15 至 2016-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9004266
• 关键词: African American; Age; American; American Heart Association; Ancillary Study; Atrial Fibrillation; Behavioral; Biological Markers; Blood Vessels; Cardiology; Cardiovascular Diseases; Cardiovascular system; Caring; Cessation of life; Clinic; Clinical; Cohort Studies; Communities; Contracts; Coronary heart disease; County; Data Coordinating Center; Dietary intake; Environmental Risk Factor; Epidemiologic Studies; Etiology; Event; Genetic; Genetic Markers; Health Status; Heart failure; Incidence; Individual; Inpatients; Measurement; Medical; Monitor; Myocardial Infarction; Natural History; Outcome; Outcomes Research; Outpatients; Participant; Probability Samples; Recruitment Activity; Research Personnel; Risk Factors; Staging; Stroke; Telephone; Training; Ventricular Dysfunction; Visit; Washington; Woman; aged; cohort; college; data sharing; demographics; design; follow-up; human old age (65+); member; men; mortality; prospective; pulmonary function; social; trend

ARIC is a prospective epidemiologic study conducted in four U.S. communities: Washington County, MD; Forsyth County, NC; Jackson, MS; and Minneapolis, MN. The study is designed to monitor the trends in incidence and mortality of coronary heart disease (CHD) and heart failure in communities, and to investigate the etiology, natural history, and progression of subclinical and clinical cardiovascular disease such as CHD, heart failure, and stroke. Accordingly, ARIC includes a Community Surveillance Component and Cohort Study Component. For the community surveillance, the four communities are investigated to determine the occurrence of hospitalized myocardial infarction and CHD deaths in approximately 800,000 men and women aged 35-84 years. Starting in 2006, surveillance of inpatient (ages 55 years and older) and outpatient heart failure (ages 65 years and older) is included for the events beginning in 2005. Under the new contract, community surveillance will continue to monitor long-term trends in hospitalized MI, CHD deaths, and heart failure (inpatient and outpatient). For the cohort study, approximately 4,000 individuals aged 45-64 years were recruited by probability sampling from each of the four communities under surveillance. A total of 15,792 participants (11,478 whites, 4,266 African Americans, and 48 other) received an extensive baseline examination in 1987-1989. Three repeat examinations were conducted in 1990-92, 1993-95, and 1996-98. The examinations collected information on demographics, psycho-social and behavioral factors, dietary intakes, physical measurements, and biological and genetic markers. Under the new contract, the surviving cohort members will receive another clinic exam to characterize heart failure stages, identify genetic and environmental factors leading to ventricular dysfunction and vascular stiffness, and assess longitudinal changes in pulmonary function and identify determinants of its decline. Participants are also contacted twice a year by telephone to assess health status. Under the new contract, the study will also be enhanced with cardiovascular outcomes research to assess quality and outcomes of medical care for heart failure risk factors and heart failure.

ARIC是一项在美国四个社区进行的前瞻性流行病学研究：马里兰州华盛顿县；福赛斯县，北卡罗来纳州；杰克逊女士;以及明尼苏达州的明尼阿波利斯。该研究旨在监测社区冠心病和心力衰竭的发病率和死亡率趋势，并调查亚临床和临床心血管疾病（如冠心病、心力衰竭和中风）的病因、自然病史和进展情况。因此，ARIC包括社区监测部分和队列研究部分。