NIDDK BIOSAMPLE AND GENETICS REPOSITORY CONTRACT.

NIDDK开展并支持许多内科疾病和相关专科领域的临床研究。NIDDK资助的许多大型临床研究从受试者身上收集生物标本用于分析和未来的研究。从许多不同的研究中收集这些患者和对照样本，这是一个有价值的资源，研究人员可以通过它快速验证临床假设和临床决策算法。该收藏还推动了与NIDDK使命相关的疾病的预后、标志物和治疗方法的发展。发现疾病相关基因需要具有遗传变异的个体群体，以及控制（未受影响）个体群体。因此，遗传材料的储存库，包括DNA样本、冷冻保存的淋巴细胞、永生化细胞系以及伴随的临床和系谱数据，显然是研究与NIDDK使命相关的疾病的研究界的宝贵资源。该资源库将允许继续储存、维护和质量控制，以及公平、合乎道德地分配DNA和其他对疾病研究具有重要意义的资源。它有助于资源共享，从而鼓励广泛的研究人员开展工作，并可能增加样本量和由此产生的确定疾病遗传决定因素的研究能力。它有助于确保研究参与者将作出最大的贡献，并减少重复的抽样努力。这个项目延续了2003年开始的一个重要的收集，在概念上与NIH其他研究所现有的存储库相关。

The NIDDK conducts and supports much of the clinical research on the diseases of internal medicine and related subspecialty fields. Many of the large clinical studies funded by the NIDDK collect biospecimens from subjects for analysis and future study. The collection of these patient and control samples from many different studies in a single repository is a valuable resource with which researchers can rapidly validate clinical hypotheses and algorithms for clinical decision. The collection is also advancing the development of prognostics, markers, and therapeutics for diseases related to the mission of the NIDDK. Discovery of disease related genes requires a population of individuals with the genetic variant, as well as a population of control (unaffected) individuals. Thus, a repository of genetic materials, including DNA samples, cryopreserved lymphocytes, immortalized cell lines, and accompanying clinical and pedigree data is clearly an invaluable resource for the research community studying diseases related to the mission of the NIDDK. The repository will allow the continued storage, maintenance, and quality control, and equitable, ethical distribution of DNA and other resources important to the study of diseases under the mandate of the NIDDK. It facilitates sharing of resources, thus encouraging work by a broad group of investigators and, perhaps, increasing the sample size and the resulting power of a study to identify genetic determinants of a disease. It helps to ensure that research participants will be making a maximal contribution, and decreases duplicative sampling efforts. This project, continues an important collection begun in 2003 and is conceptually related to repositories in existence at other institutes at the NIH.