NIDDK BIOSAMPLE AND GENETICS REPOSITORY CONTRACT.

NIDDK进行和支持许多内科疾病和相关专科领域的临床研究。许多由NIDDK资助的大型临床研究从受试者中收集生物标本进行分析和未来研究。将来自许多不同研究的这些患者和对照样本收集在一个存储库中是一种宝贵的资源，研究人员可以利用它快速验证临床假设和临床决策算法。该系列还推动了与NIDDK使命相关的疾病的免疫学、标志物和治疗方法的发展。疾病相关基因的发现需要具有遗传变异的个体群体以及对照（未受影响的）个体群体。因此，一个遗传物质的储存库，包括DNA样本、冷冻保存的淋巴细胞、永生化细胞系以及伴随的临床和谱系数据，对于研究与NIDDK的使命相关的疾病的研究界来说，显然是一个宝贵的资源。该储存库将允许继续存储，维护和质量控制，以及公平，道德地分配DNA和其他对NIDDK任务下的疾病研究至关重要的资源。它促进了资源的共享，从而鼓励了广泛的研究人员的工作，并可能增加样本量，从而提高研究确定疾病遗传决定因素的能力。它有助于确保研究参与者将作出最大贡献，并减少重复抽样工作。该项目延续了2003年开始的一项重要收集，在概念上与NIH其他研究所现有的储存库有关。

The NIDDK conducts and supports much of the clinical research on the diseases of internal medicine and related subspecialty fields. Many of the large clinical studies funded by the NIDDK collect biospecimens from subjects for analysis and future study. The collection of these patient and control samples from many different studies in a single repository is a valuable resource with which researchers can rapidly validate clinical hypotheses and algorithms for clinical decision. The collection is also advancing the development of prognostics, markers, and therapeutics for diseases related to the mission of the NIDDK. Discovery of disease related genes requires a population of individuals with the genetic variant, as well as a population of control (unaffected) individuals. Thus, a repository of genetic materials, including DNA samples, cryopreserved lymphocytes, immortalized cell lines, and accompanying clinical and pedigree data is clearly an invaluable resource for the research community studying diseases related to the mission of the NIDDK. The repository will allow the continued storage, maintenance, and quality control, and equitable, ethical distribution of DNA and other resources important to the study of diseases under the mandate of the NIDDK. It facilitates sharing of resources, thus encouraging work by a broad group of investigators and, perhaps, increasing the sample size and the resulting power of a study to identify genetic determinants of a disease. It helps to ensure that research participants will be making a maximal contribution, and decreases duplicative sampling efforts. This project, continues an important collection begun in 2003 and is conceptually related to repositories in existence at other institutes at the NIH.