NIDDK BIOSAMPLE AND GENETICS REPOSITORY CONTRACT.

NIDDK 生物样本和遗传学存储库合同。

• 批准号: 10329681
• 负责人: CHANI EDUARD
• 金额: $ 402.42万
• 依托单位: PRECISION BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-28 至 2021-11-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10329681
• 关键词: Advanced Development; Algorithms; Blood specimen; Cell Line; Clinical; Clinical Research; Collaborations; Collection; Communities; Contracts; Cryopreservation; Custom; DNA; Data; Disease; Ensure; Ethics; Funding; Future; Genes; Genetic; Genetic Determinism; Genetic Materials; Grant; Individual; Institutes; Internal Medicine; Lymphocyte; Maintenance; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Participant; Patients; Population; Population Control; Process; Prognostic Marker; Quality Control; RNA; Research; Research Personnel; Resource Sharing; Resources; Sample Size; Sampling; Therapeutic; United States National Institutes of Health; Work; cell immortalization; cost effective; genetic pedigree; genetic variant; novel strategies; repository

The NIDDK conducts and supports much of the clinical research on the diseases of internal medicine and related subspecialty fields. Many of the large clinical studies funded by the NIDDK collect biospecimens from subjects for analysis and future study. The collection of these patient and control samples from many different studies in a single repository is a valuable resource with which researchers can rapidly validate clinical hypotheses and algorithms for clinical decision. The collection is also advancing the development of prognostics, markers, and therapeutics for diseases related to the mission of the NIDDK. Discovery of disease related genes requires a population of individuals with the genetic variant, as well as a population of control (unaffected) individuals. Thus, a repository of genetic materials, including DNA samples, cryopreserved lymphocytes, immortalized cell lines, and accompanying clinical and pedigree data is clearly an invaluable resource for the research community studying diseases related to the mission of the NIDDK. The repository will allow the continued storage, maintenance, and quality control, and equitable, ethical distribution of DNA and other resources important to the study of diseases under the mandate of the NIDDK. It facilitates sharing of resources, thus encouraging work by a broad group of investigators and, perhaps, increasing the sample size and the resulting power of a study to identify genetic determinants of a disease. It helps to ensure that research participants will be making a maximal contribution, and decreases duplicative sampling efforts. This project, continues an important collection begun in 2003 and is conceptually related to repositories in existence at other institutes at the NIH.

NIDDK 开展并支持内科疾病和相关亚专业领域的大部分临床研究。 NIDDK 资助的许多大型临床研究都会从受试者身上收集生物样本以供分析和未来研究。将来自许多不同研究的这些患者和对照样本收集在一个存储库中是一种宝贵的资源，研究人员可以利用它快速验证临床假设和临床决策算法。该集合还推动与 NIDDK 使命相关的疾病的预后、标记物和治疗方法的开发。疾病相关基因的发现需要具有遗传变异的个体群体以及对照（未受影响）个体群体。因此，遗传物质库，包括 DNA 样本、冷冻保存的淋巴细胞、永生化细胞系以及随附的临床和谱系数据，显然对于研究与 NIDDK 使命相关的疾病的研究界来说是宝贵的资源。该存储库将允许持续存储、维护和质量控制，以及公平、道德地分配 DNA 和其他对 NIDDK 授权下的疾病研究重要的资源。它促进资源共享，从而鼓励广泛的研究人员开展工作，或许还可以增加样本量以及由此产生的研究能力，以确定疾病的遗传决定因素。它有助于确保研究参与者做出最大的贡献，并减少重复抽样工作。该项目是 2003 年开始的重要收集的延续，在概念上与 NIH 其他研究所现有的存储库相关。