NIDDK BIOSAMPLE AND GENETICS REPOSITORY CONTRACT.

NIDDK 生物样本和遗传学存储库合同。

• 批准号: 10788119
• 负责人: CHANI EDUARD
• 金额: $ 219.45万
• 依托单位: PRECISION BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-28 至 2023-05-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788119
• 关键词: Advanced Development; Algorithms; Blood specimen; Cell Line; Clinical; Clinical Research; Collaborations; Collection; Communities; Contracts; Cryopreservation; DNA; Data; Disease; Equity; Ethics; Exclusion; Funding; Future; Genes; Genetic; Genetic Determinism; Genetic Materials; Grant; Individual; Internal Medicine; Lymphocyte; Maintenance; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Participant; Patients; Population; Population Control; Process; Qualifying; Quality Control; RNA; Research; Research Personnel; Resource Sharing; Resources; Sample Size; Sampling; Therapeutic; United States National Institutes of Health; Work; cell immortalization; cost effective; genetic pedigree; genetic variant; novel strategies; prognostic; repository

The NIDDK conducts and supports much of the clinical research on the diseases of internal medicine and related subspecialty fields. Many of the large clinical studies funded by the NIDDK collect biospecimens from subjects for analysis and future study. The collection of these patient and control samples from many different studies in a single repository is a valuable resource with which researchers can rapidly validate clinical hypotheses and algorithms for clinical decision. The collection is also advancing the development of prognostics, markers, and therapeutics for diseases related to the mission of the NIDDK. Discovery of disease related genes requires a population of individuals with the genetic variant, as well as a population of control (unaffected) individuals. Thus, a repository of genetic materials, including DNA samples, cryopreserved lymphocytes, immortalized cell lines, and accompanying clinical and pedigree data is clearly an invaluable resource for the research community studying diseases related to the mission of the NIDDK. The repository will allow the continued storage, maintenance, and quality control, and equitable, ethical distribution of DNA and other resources important to the study of diseases under the mandate of the NIDDK. It facilitates sharing of resources, thus encouraging work by a broad group of investigators and, perhaps, increasing the sample size and the resulting power of a study to identify genetic determinants of a disease. It helps to ensure that research participants will be making a maximal contribution, and decreases duplicative sampling efforts. This project, continues an important collection begun in 2003 and is conceptually related to repositories in existence at other institutes at the NIH.

NIDDK开展并支持内科疾病及相关专科领域的大部分临床研究。许多由NIDDK资助的大型临床研究都从受试者那里收集生物标本，以供分析和未来研究。在一个储存库中收集来自许多不同研究的这些患者和对照样本是一个宝贵的资源，研究人员可以利用这些资源快速验证临床假设和临床决策算法。这些藏品还推动了与NIDDK使命相关的疾病的预后、标记物和治疗学的发展。疾病相关基因的发现需要一个具有遗传变异的个体群体，以及一个对照(未受影响的)个体群体。因此，遗传物质的储存库，包括DNA样本、冷冻保存的淋巴细胞、永生化细胞系，以及伴随的临床和谱系数据，显然是研究与NIDDK任务有关的疾病的研究界的宝贵资源。该储存库将允许继续储存、维护和质量控制，以及公平、合乎道德地分配DNA和其他对NIDDK授权下的疾病研究重要的资源。它促进了资源的共享，从而鼓励了广泛的研究人员的工作，并可能增加样本规模和研究结果的力量，以确定一种疾病的遗传决定因素。它有助于确保研究参与者做出最大贡献，并减少重复的抽样工作。该项目延续了2003年开始的一项重要收藏，在概念上与国家卫生研究院其他研究所现有的储存库有关。