Transcriptional control of neuronal plasticity by daf-16/FoxO
Transcriptional control of neuronal plasticity by daf-16/FoxO
批准号:
9914697
负责人:
Oliver Hobert
金额:
$44.55万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-12-01 至 2022-11-30
关键词:
AnimalsApplications GrantsBiochemicalCaenorhabditis elegansCell NucleusCellsCommunicationCuesElectrical SynapseEndocrine systemEnvironmentEventG-Protein-Coupled ReceptorsGene ExpressionGenesGeneticGenetic TranscriptionGoalsIGF1 geneIndividualInsulinInsulin-Like Growth Factor IInsulin-Like Growth Factor ReceptorInvertebratesLifeNematodaNervous system structureNeuronal PlasticityNeuronsNeuropeptide GeneNeuropeptidesNuclear TranslocationPathway interactionsPerceptionPhenotypePhylogenetic AnalysisPropertyRegulator GenesRepressionResolutionSensorySignal TransductionSpecificityStimulusSystemTechnologyTestingTranscriptional Regulationcell typegene repressiongenetic analysishormonal signalsmutantprogramsresponsetranscription factor
中文摘要
许多神经元表现出非凡的能力来改变特定的表型特性
内部或外部环境的变化。这种“神经元可塑性”现象必须
与定义完全差异化状态的基因硬连接的监管计划相交
神经元。我们建议在这里研究这种硬连线的基因调控程序是如何被修改的
使神经系统能够在特定的条件下改变神经元的特定表型
条件。我们在线虫C.的背景下研究了单神经元分辨率问题。
其神经系统根据系统发育改变了许多特征的秀丽动物
保守的胰岛素/IGF1样激素信号系统。我们在这份赠款提案中提出并测试了
胰岛素/IGF-1调控的DAF-16/FoxO转录因子在许多细胞中自主作用
控制上调或下调的特定靶基因表达的不同神经元类型
以响应特定的环境条件。我们提出并测试了DAF-16/FoxO的协同工作
通过神经元型特异性末端选择器转录来促进或拮抗
这些转录因子控制它们的效应器基因。
英文摘要
Many neurons display the remarkable ability to alter specific phenotypic properties in response to
changes in the internal or external environment. Such “neuronal plasticity” phenomena must
intersect with genetically hardwired regulatory programs that define the fully differentiated state of a
neuron. We propose here to investigate how such hardwired gene regulatory programs are modified
to enable the nervous system to change specific phenotypic aspects of a neuron under specific
conditions. We study this problem with single neuron resolution in the context of the nematode C.
elegans whose nervous system remodels a number of features in response to the phylogenetically
conserved insulin/IGF1-like hormonal signaling system. We propose and test in this grant proposal
that the insulin/IGF-1-controlled DAF-16/FoxO transcription factors acts cell autonomously in many
different neuron types to control the expression of specific target genes that are up- or downregulated
in response to specific environmental conditions. We propose and test that DAF-16/FoxO cooperates
with neuron-type specific terminal selector transcription to either promote or antagonize the ability of
these transcription factors to control their effector genes.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1371/journal.pbio.3001204
发表时间:
2021-04
期刊:
PLoS biology
影响因子:
9.8
作者:
[Aghayeva U, Bhattacharya A, Sural S, Jaeger E, Churgin M, Fang-Yen C, Hobert O]
通讯作者:
Hobert O
DOI:
10.17912/micropub.biology.000210
发表时间:
2020-01-07
期刊:
microPublication biology
影响因子:
--
作者:
[Aghayeva, Ulkar, Bhattacharya, Abhishek, Hobert, Oliver]
通讯作者:
Hobert, Oliver
A nervous system-wide analysis of C. elegans homeobox gene function
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批准号:9545254
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项目类别:
-
资助金额:$23.41万
-
财政年份:2018
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负责人:Oliver Hobert
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依托单位:
Building an expression atlas of C.elegans sensory receptors
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批准号:9089723
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项目类别:
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资助金额:$23.65万
-
财政年份:2016
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负责人:Oliver Hobert
-
依托单位:
Developing drivers for neuron type-specific gene expression
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批准号:9074073
-
项目类别:
-
资助金额:$9.28万
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财政年份:2015
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负责人:Oliver Hobert
-
依托单位:
Developing drivers for neuron type-specific gene expression
-
批准号:8935927
-
项目类别:
-
资助金额:$62.6万
-
财政年份:2014
-
负责人:Oliver Hobert
-
依托单位:
Developing drivers for neuron type-specific gene expression
-
批准号:8821299
-
项目类别:
-
资助金额:$62.6万
-
财政年份:2014
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负责人:Oliver Hobert
-
依托单位:
Generating neurons through cellular reprogramming
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批准号:8204269
-
项目类别:
-
资助金额:$23.68万
-
财政年份:2011
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负责人:Oliver Hobert
-
依托单位:
Generating neurons through cellular reprogramming
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批准号:8259131
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项目类别:
-
资助金额:$19.75万
-
财政年份:2011
-
负责人:Oliver Hobert
-
依托单位:
Genetic mechanisms that regulate left/right asymmetric neuron size
-
批准号:7928768
-
项目类别:
-
资助金额:$7.61万
-
财政年份:2009
-
负责人:Oliver Hobert
-
依托单位:
Genetic mechanisms that regulate left/right asymmetric neuron size
-
批准号:7773011
-
项目类别:
-
资助金额:$7.59万
-
财政年份:2009
-
负责人:Oliver Hobert
-
依托单位:
A genome-wide RNAi screen for Neuronal Cell Fate Mutants
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批准号:7683135
-
项目类别:
-
资助金额:$7.63万
-
财政年份:2008
-
负责人:Oliver Hobert
-
依托单位:
Stem Cells and Cell Lineage Specification
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批准号:7233441
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项目类别:
-
资助金额:$27.2万
-
财政年份:2007
-
负责人:Oliver Hobert
-
依托单位:
Stem Cells and Cell Lineage Specification
-
批准号:7614986
-
项目类别:
-
资助金额:$27.58万
-
财政年份:2007
-
负责人:Oliver Hobert
-
依托单位:
SEARCH FOR INTERACTORS OF EGL-15 AND SAX-7 IN THE C ELEGANS NERVOUS SYSTEM
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批准号:7602199
-
项目类别:
-
资助金额:$0.62万
-
财政年份:2007
-
负责人:Oliver Hobert
-
依托单位:
Stem Cells and Cell Lineage Specification
-
批准号:8064364
-
项目类别:
-
资助金额:$27.87万
-
财政年份:2007
-
负责人:Oliver Hobert
-
依托单位:
Stem Cells and Cell Lineage Specification
-
批准号:7862485
-
项目类别:
-
资助金额:$24.79万
-
财政年份:2007
-
负责人:Oliver Hobert
-
依托单位:
Stem Cells and Cell Lineage Specification
-
批准号:7416622
-
项目类别:
-
资助金额:$27.2万
-
财政年份:2007
-
负责人:Oliver Hobert
-
依托单位:
Genome-wide expression profiling of miRNAs with single cell resolution
-
批准号:7074631
-
项目类别:
-
资助金额:$7.86万
-
财政年份:2005
-
负责人:Oliver Hobert
-
依托单位:
Left/right asymmetric neuronal cell fate specification
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批准号:7074016
-
项目类别:
-
资助金额:$7.86万
-
财政年份:2005
-
负责人:Oliver Hobert
-
依托单位:
Left/right asymmetric neuronal cell fate specification
-
批准号:6955079
-
项目类别:
-
资助金额:$8.05万
-
财政年份:2005
-
负责人:Oliver Hobert
-
依托单位:
Genome-wide expression profiling of miRNAs
-
批准号:6955076
-
项目类别:
-
资助金额:$8.05万
-
财政年份:2005
-
负责人:Oliver Hobert
-
依托单位: