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中文摘要
翻译
许多神经元显示出改变特定表型特性的非凡能力
英文摘要
Many neurons display the remarkable ability to alter specific phenotypic properties in response to changes in the internal or external environment. Such “neuronal plasticity” phenomena must intersect with genetically hardwired regulatory programs that define the fully differentiated state of a neuron. We propose here to investigate how such hardwired gene regulatory programs are modified to enable the nervous system to change specific phenotypic aspects of a neuron under specific conditions. We study this problem with single neuron resolution in the context of the nematode C. elegans whose nervous system remodels a number of features in response to the phylogenetically conserved insulin/IGF1-like hormonal signaling system. We propose and test in this grant proposal that the insulin/IGF-1-controlled DAF-16/FoxO transcription factors acts cell autonomously in many different neuron types to control the expression of specific target genes that are up- or downregulated in response to specific environmental conditions. We propose and test that DAF-16/FoxO cooperates with neuron-type specific terminal selector transcription to either promote or antagonize the ability of these transcription factors to control their effector genes.
期刊论文(2)
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会议论文
DOI: 10.1371/journal.pbio.3001204
发表时间: 2021-04
期刊: PLoS biology
影响因子: 9.8
作者: [Aghayeva U, Bhattacharya A, Sural S, Jaeger E, Churgin M, Fang-Yen C, Hobert O]
通讯作者: Hobert O
DOI: 10.17912/micropub.biology.000210
发表时间: 2020-01-07
期刊: microPublication biology
影响因子: --
作者: [Aghayeva, Ulkar, Bhattacharya, Abhishek, Hobert, Oliver]
通讯作者: Hobert, Oliver
A nervous system-wide analysis of C. elegans homeobox gene function
Building an expression atlas of C.elegans sensory receptors
Developing drivers for neuron type-specific gene expression
Developing drivers for neuron type-specific gene expression