Building an expression atlas of C.elegans sensory receptors

建立线虫感觉受体的表达图谱

• 批准号: 9089723
• 负责人: Oliver Hobert
• 金额: $ 23.65万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9089723
• 关键词: Anatomy; Animals; Atlases; Behavior; Biological Models; Biological Process; C. elegans genome; Caenorhabditis elegans; Communities; Coupled; Employee Strikes; Family; Family member; Future; G-Protein-Coupled Receptors; GTP-Binding Proteins; Gene Expression; Gene Expression Profile; Gene Family; Genes; Genetic; Genetic Programming; Individual; Invertebrates; Label; Lead; Left; Life; Maps; Molecular; Monitor; Nervous system structure; Neurobiology; Neurons; Organism; Pattern; Reporter; Reporter Genes; Resolution; Resources; Sensory Receptors; Time; base; dimorphism; genetic analysis; insight; member; novel; programs; public health relevance; receptor; receptor expression; sex

 DESCRIPTION (provided by applicant): In this resource-building proposal, we follow the map-building tradition of the Caenorhadbitis elegans field, aiming to generate an extensive expression atlas of sensory receptors of the G-protein- coupled receptor family. We predict that such an expression pattern will reveal: (a) patterns of left/right asymmetric gene expression, pointing to functional lateralization of neuron pairs; (b) patterns of sexually dimorphic gene expression, pointing to neurons involved in sexually dimorphic behaviors; (c) temporally controlled patterns of gene expression, pointing to neurons that alter their function over time. The genetic programs that instruct left-right asymmetric, sexually dimorphic and temporally controlled features of the nervous system are poorly understood and we anticipate that our identification of gene expression patterns that display such features will provide powerful entry points into studying how these features are programmed.

 描述（由申请人提供）：在这个资源建设建议中，我们遵循秀丽隐杆线虫领域的地图建设传统，旨在生成G蛋白偶联受体家族的感觉受体的广泛表达图谱。我们预测，这样的表达模式将揭示：（a）左/右不对称基因表达模式，指向神经元对的功能偏侧化;（B）性二态基因表达模式，指向参与性二态行为的神经元;（c）时间控制的基因表达模式，指向随着时间的推移改变其功能的神经元。指导左右不对称，性二态性和时间控制功能的神经系统的遗传程序知之甚少，我们预计，我们的基因表达模式，显示这些功能的识别将提供强大的切入点，研究这些功能是如何编程。