Building an expression atlas of C.elegans sensory receptors

 描述(申请人提供)：在这个资源建设提案中，我们遵循秀丽线虫领域的地图构建传统，旨在生成G蛋白偶联受体家族的感觉受体的广泛表达图谱。我们预测，这样的表达模式将揭示：(A)左右不对称基因表达模式，指向神经元对的功能侧化；(B)性二态基因表达模式，指向参与性二态行为的神经元；(C)时间控制的基因表达模式，指向随时间改变其功能的神经元。指导神经系统左右不对称、性二态和时间控制特征的遗传程序还知之甚少，我们预计，我们识别出表现这些特征的基因表达模式将为研究这些特征是如何编程的提供强有力的切入点。

 DESCRIPTION (provided by applicant): In this resource-building proposal, we follow the map-building tradition of the Caenorhadbitis elegans field, aiming to generate an extensive expression atlas of sensory receptors of the G-protein- coupled receptor family. We predict that such an expression pattern will reveal: (a) patterns of left/right asymmetric gene expression, pointing to functional lateralization of neuron pairs; (b) patterns of sexually dimorphic gene expression, pointing to neurons involved in sexually dimorphic behaviors; (c) temporally controlled patterns of gene expression, pointing to neurons that alter their function over time. The genetic programs that instruct left-right asymmetric, sexually dimorphic and temporally controlled features of the nervous system are poorly understood and we anticipate that our identification of gene expression patterns that display such features will provide powerful entry points into studying how these features are programmed.