Sleep Cortical Dynamics and Neurobehavioral Risk in Children and Adolescents: A Longitudinal Study

项目总结 青春期是生理和心理成熟的发展阶段，在此阶段之前和 包括睡眠的变化。这也是与精神疾病的发病相关的关键时期。 然而，儿童的睡眠大脑如何预测包括神经认知在内的精神病理学的发展 以及青春期以后的情绪障碍，人们对此仍然知之甚少。为了弥合这一差距， 我们已经收集了初步数据，表明大脑活动在特定睡眠时期的变化 睡眠阶段与睡眠障碍、执行缺陷和内在化显著相关 儿童、青少年和年轻人的症状。重要的是，这个项目将在我们以前工作的基础上进行扩展 在这方面，我们有机会对宾夕法尼亚州立大学儿童队列进行纵向分析， 以人口为基础的700名幼儿样本，他们参与了一项全面的睡眠研究，以及 神经认知、行为和医学评估。这项研究将为我们提供关于 在常规临床实践中通常被忽视的睡眠期间大脑活动的变化与 存在于多种精神障碍中的认知和情绪过程。它还将使我们能够 为了检验这一新的假设，即睡眠期间大脑活动的变化与患高血压风险的增加有关 在这个重要的过渡时期，神经认知障碍和精神病理学的发展。

PROJECT SUMMARY Adolescence is a developmental stage of physical and psychological maturation that is preceded by and includes changes in sleep. It is also a critical period associated with the onset of psychiatric disorders. However, how a child's sleeping brain predicts the development of psychopathology, including neurocognitive and emotional disorders, later on during adolescence remains poorly understood. In order to bridge this gap, we have collected preliminary data that suggests that changes in brain activity during specific sleep periods and stages of sleep are significantly associated with sleep disorders and executive deficits and internalizing symptoms in children, adolescents and young adults. Importantly, this project will expand on our previous work in this area by giving us the opportunity to conduct longitudinal analyses of the Penn State Child Cohort, a population-based sample of 700 young children, who participated in a comprehensive sleep study, and neurocognitive, behavioral and medical assessment. This study will provide us with novel findings on the association of changes in brain activity during sleep, typically neglected in routine clinical practice, with cognitive and emotional processes that are present across multiple psychiatric disorders. It will also enable us to test the novel hypothesis that changes in brain activity during sleep are associated with increased risk for the development of neurocognitive disorders and psychopathology during this important transitional period.