Sleep Cortical Dynamics and Neurobehavioral Risk in Children and Adolescents: A Longitudinal Study

儿童和青少年的睡眠皮质动力学和神经行为风险：一项纵向研究

• 批准号: 10093138
• 负责人: Julio Fernandez-Mendoza
• 金额: $ 41.85万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-17 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10093138
• 关键词: 12 year old; Address; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Age; Area; Attention deficit hyperactivity disorder; Behavioral; Biological Markers; Brain; Child; Child Behavior Checklist; Childhood; Clinical; Cognitive; Cognitive deficits; Cross-Sectional Studies; Data; Development; Early Diagnosis; Early treatment; Electroencephalography; Emotional; Emotional disorder; Female; Frequencies; General Population; Hydrocortisone; Inflammation; Longitudinal Studies; Measures; Medical; Mental Depression; Mental disorders; National Institute of Mental Health; Neurocognitive; Neurocognitive Deficit; Neurodevelopmental Disorder; Outcome; Patients; Phase; Process; Psychopathology; Research; Risk; Sampling; Sex Differences; Short-Term Memory; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Stages; Sleeplessness; Strategic Planning; Symptoms; System; Testing; Time; Work; age difference; behavioral outcome; boys; clinical practice; cohort; critical period; emotional functioning; executive function; experience; externalizing behavior; longitudinal analysis; male; neglect; neurobehavioral; neurocognitive disorder; neurophysiology; novel; population based; prepuberty; primary outcome; psychologic; secondary outcome; sleep onset; substance use; synaptic pruning

PROJECT SUMMARY Adolescence is a developmental stage of physical and psychological maturation that is preceded by and includes changes in sleep. It is also a critical period associated with the onset of psychiatric disorders. However, how a child's sleeping brain predicts the development of psychopathology, including neurocognitive and emotional disorders, later on during adolescence remains poorly understood. In order to bridge this gap, we have collected preliminary data that suggests that changes in brain activity during specific sleep periods and stages of sleep are significantly associated with sleep disorders and executive deficits and internalizing symptoms in children, adolescents and young adults. Importantly, this project will expand on our previous work in this area by giving us the opportunity to conduct longitudinal analyses of the Penn State Child Cohort, a population-based sample of 700 young children, who participated in a comprehensive sleep study, and neurocognitive, behavioral and medical assessment. This study will provide us with novel findings on the association of changes in brain activity during sleep, typically neglected in routine clinical practice, with cognitive and emotional processes that are present across multiple psychiatric disorders. It will also enable us to test the novel hypothesis that changes in brain activity during sleep are associated with increased risk for the development of neurocognitive disorders and psychopathology during this important transitional period.

项目摘要 青春期是身体和心理成熟的一个发展阶段，在此之前， 包括睡眠的变化。这也是一个与精神疾病发作有关的关键时期。 然而，儿童的睡眠大脑如何预测精神病理学的发展，包括神经认知 和情绪障碍，在青春期后期仍然知之甚少。为了弥合这一差距， 我们已经收集了初步的数据，这些数据表明，在特定的睡眠期间， 睡眠的不同阶段与睡眠障碍、执行缺陷和内在化有着显著的联系。 儿童、青少年和年轻人的症状。重要的是，这个项目将扩大我们以前的工作 在这方面，我们有机会对宾夕法尼亚州立大学的儿童队列进行纵向分析， 700名幼儿参与了一项全面的睡眠研究， 神经认知行为和医学评估这项研究将为我们提供新的发现 睡眠期间大脑活动的变化（通常在常规临床实践中被忽视）与 认知和情感过程，这些过程存在于多种精神疾病中。它还将使我们 为了验证这一新的假设，即睡眠期间大脑活动的变化与睡眠风险增加有关。 神经认知障碍和精神病理学的发展在这一重要的过渡时期。