A Dyadic Sleep Intervention for Alzheimers Disease Patients and Their Caregivers

针对阿尔茨海默病患者及其护理人员的二元睡眠干预

• 批准号: 9918212
• 负责人: Yeonsu Song
• 金额: $ 19.61万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-15 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9918212
• 关键词: Address; Admission activity; Advanced Practice Nurse; Aftercare; Alzheimer' s Disease; Alzheimer' s disease caregiver; Alzheimer' s disease patient; American; Area; Behavioral; Biological Markers; Biological Process; Board Certification; C-reactive protein; Capsicum; Cardiovascular system; Caregivers; Chronic Disease; Cognitive; Control Groups; Data; Dementia; Doctor of Philosophy; Education; Elderly; Event; Family Nursing; Fellowship; Focus Groups; Funding; Future; Gene Expression; Genomics; Geriatrics; Gerontology; Goals; Health; Health Care Costs; Healthcare Systems; Home visitation; Hour; Hypertension; Impaired cognition; Individual; Inflammation; Inflammatory; Institution; Institutionalization; Intervention; Intervention Studies; Knowledge; Los Angeles; Measures; Medicine; Mentors; Methods; Nature; Non-Insulin-Dependent Diabetes Mellitus; Nurse Practitioners; Nursing Homes; Outcome; Patient Care; Patients; Phase; Pilot Projects; Preparation; Public Health; Quality of Care; Quality of life; Randomized Controlled Trials; Recommendation; Research; Research Activity; Research Personnel; Research Training; Resources; Risk; Sleep; Sleep Disorders; Sleep disturbances; Stress; Structure; Techniques; Telephone; Testing; Time; Training; United States National Institutes of Health; Veterans; Work; actigraphy; base; career development; caregiver interventions; clinical center; community setting; compression therapy; economic value; educational atmosphere; experience; follow-up; improved; improvement on sleep; inflammatory marker; informal caregiver; innovation; interest; intervention effect; intervention program; medical schools; meetings; member; mortality risk; novel; prevent; primary outcome; professor; programs; skills; sleep health; sleep quality; trial design; usability

Project Summary/Abstract Yeonsu Song, PhD, RN, FNP-C is an Assistant Professor at the David Geffen School of Medicine at UCLA and is fully committed to becoming an independently-funded investigator specializing in sleep in individuals with cognitive impairments such as Alzheimer’s disease (AD) and their caregivers. She has a particular interest in testing a dyadic sleep intervention program for Alzheimer’s disease patients and their informal caregivers. Dr. Song’s unique background makes her an ideal candidate for this field of research. She has fellowship training in advanced geriatrics, and has board certification in advanced practice nursing as a family nurse practitioner. She is currently supported by an Advanced Fellowship in Geriatrics through the Veterans Affairs (VA) Greater Los Angeles Healthcare System, Geriatric Research, Education, and Clinical Center (GRECC). Career development and training plan: This plan features an outstanding research and educational environment at UCLA, with nationally renowned expert mentors. Her primary mentoring team is comprised of Drs. Jennifer Martin (expert in behavioral sleep interventions), Cathy Alessi (expert in sleep medicine), Michael Irwin (expert in inflammatory factors and sleep), and Edmond Teng (expert in assessment of AD). She will also draw on resources available through UCLA’s CTSI, UCLA’s Multicampus Program in Geriatric Medicine and Gerontology, UCLA’s Claude D. Pepper Center, and the GRECC. Her training plan features carefully curated coursework and hands-on training experiences, all aligned with her training goals. Research plan: The proposed research is hypothesis-driven and guided by preliminary data from Dr. Song’s VA-funded pilot study and existing behavioral sleep intervention methods. During the past 2 years of her fellowship, she has developed a dyadic sleep intervention program. In phase 1 (Aim 1), she will iteratively refine and finalize the intervention program targeting both members of the dyad (patients and caregivers) by evaluating acceptability and usability. In phase 2 (Aims 2-4) she will pilot test the program effects by assessing sleep, health, and quality of life in both members of the group using a small randomized controlled trial design, with the main analyses focused on caregiver outcomes. The intervention program will involve five sessions, including 4 home visits and one telephone session. It will include manualized sleep hygiene recommendations and a behavioral sleep intervention including sleep compression therapy. A unique aspect of the proposed work is that the program is tailored to address sleep problems of both patients and caregivers, and includes upstream biomarkers to evaluate a key mechanism of intervention benefits that can be further explored in future research. Skills developed from executing this training and research plan will enable Dr. Song to become an independent researcher and a leader in research on managing sleep in AD patients and their caregivers, with the goal of improving their health and quality of life.

项目总结/摘要 Yeonsu Song博士，注册护士，FNP-C是加州大学洛杉矶分校大卫格芬医学院的助理教授， 完全致力于成为一个独立资助的研究人员专门研究睡眠的个人与 认知障碍，如阿尔茨海默病（AD）及其护理人员。她对 对阿尔茨海默病患者和他们的非正式照顾者进行二元睡眠干预计划的测试。博士 宋的独特背景使她成为这一研究领域的理想人选。她接受过奖学金培训 高级老年病学，并拥有家庭护士执业高级实践护理委员会认证。 她目前通过退伍军人事务部（VA）更大的老年医学高级奖学金支持 洛杉矶医疗保健系统，老年医学研究，教育和临床中心（GRECC）。 职业发展和培训计划：该计划的特点是突出的研究和教育 加州大学洛杉矶分校的环境，与全国知名的专家导师。她的主要指导团队由 Drs. Jennifer Martin（行为睡眠干预专家），Cathy Alessi（睡眠医学专家），Michael 欧文（炎症因子和睡眠方面的专家）和Edmond Teng（AD评估专家）。她还将 利用加州大学洛杉矶分校的CTSI，加州大学洛杉矶分校的老年医学多校区计划和 老年学，加州大学洛杉矶分校的克劳德D。佩珀中心和GRECC她的训练计划精心策划， 课程作业和实践培训经验，所有这些都与她的培训目标一致。 研究计划：拟议的研究是假设驱动的，并由宋博士的初步数据指导。 VA资助的试点研究和现有的行为睡眠干预方法。在过去的两年里，她 在研究员的帮助下，她开发了一个二元睡眠干预计划。在第1阶段（目标1），她将迭代 完善并最终确定针对患者和护理人员的干预方案， 评估可接受性和可用性。在第二阶段（目标2-4），她将通过评估 睡眠，健康和生活质量在两个成员的组使用一个小的随机对照试验设计， 主要的分析集中在照顾者的结果上。干预计划将包括五次会议， 包括四次家访和一次电话会议。它将包括手动睡眠卫生建议 以及包括睡眠压迫疗法的行为睡眠干预。一个独特的方面的建议 工作是，该计划是量身定制的，以解决病人和护理人员的睡眠问题，包括 上游生物标志物，以评估干预益处的关键机制，可进一步探索 未来的研究。通过执行本培训和研究计划开发的技能将使宋博士能够 成为一名独立的研究人员，并在管理AD患者及其 护理人员，以改善他们的健康和生活质量为目标。