The evolution of a co-opted gene-regulatory network underlying a rapidly evolving morphological trait

快速进化的形态特征背后的增选基因调控网络的进化

基本信息

  • 批准号:
    9920412
  • 负责人:
  • 金额:
    $ 43.79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-05-01 至 2021-04-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant) The goal of this research is to dissect the causative genes and mutations underlying a rapidly evolving complex trait and to understand the nature of constraints on the evolution of this trait. Such an endeavor requires an experimental system in which drastic changes occur over short evolutionary timeframes in species that can be easily manipulated genetically. The posterior lobe in the Drosophila melanogaster species group is a recently-derived structural feature of male genitalia important in mating. The structure has evolved strikingly different morphology in each of the four species of this group over the past two million years. Our preliminary work has documented the apparent co-option and re-deployment of a highly conserved gene regulatory network (GRN) encoding the larval posterior spiracle in creating novel phenotypic variation in the adult posterior lobe. This finding stimulates us to hypothesize mechanisms that would allow the rapidly evolving lobe to change while leaving the spiracle structure unaltered. Among the members of this GRN is the gene pox neuro (poxn) which we have shown is divergently upregulated in D. simulans relative to D. melanogaster and that over-expression in D. melanogaster leads to enlargement of the lobe as observed in D. simulans. Additionally, we have shown that the upregulation of poxn in D. simulans is caused by sequence divergence in a posterior lobe-specific enhancer contained within the gene. Using a population genetic method to detect natural selection, we have identified a signature of selection that coincides with the posterior lobe enhancer of poxn. Here, we propose to employ genomic (i.e. RNA-seq, population genomics) and molecular genetic techniques (i.e. transgenic expression and complementation assays) to identify other causative genes and mutations responsible for differences in posterior lobe size and shape among species of the D. melanogaster species group (Aims 1 and 2). With a large collection of such molecular changes in hand, we will examine how co-opted nodes of the posterior lobe have diverged in their lobe functions without altering the spiracle structure (Aim 3).


项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
On the specificity of gene regulatory networks: How does network co-option affect subsequent evolution?
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Peter Andolfatto其他文献

Peter Andolfatto的其他文献

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{{ truncateString('Peter Andolfatto', 18)}}的其他基金

The evolution of a co-opted gene-regulatory network underlying a rapidly evolving morphological trait
快速进化的形态特征背后的增选基因调控网络的进化
  • 批准号:
    9103364
  • 财政年份:
    2016
  • 资助金额:
    $ 43.79万
  • 项目类别:
The evolution of a co-opted gene-regulatory network underlying a rapidly evolving morphological trait
快速进化的形态特征背后的增选基因调控网络的进化
  • 批准号:
    9477041
  • 财政年份:
    2016
  • 资助金额:
    $ 43.79万
  • 项目类别:
Effects of genetic background on adaptive evolution
遗传背景对适应性进化的影响
  • 批准号:
    10615639
  • 财政年份:
    2015
  • 资助金额:
    $ 43.79万
  • 项目类别:
Dissecting the molecular basis and assembly of a complex morphological trait
剖析复杂形态特征的分子基础和组装
  • 批准号:
    9211338
  • 财政年份:
    2015
  • 资助金额:
    $ 43.79万
  • 项目类别:
Effects of genetic background on adaptive evolution
遗传背景对适应性进化的影响
  • 批准号:
    10397123
  • 财政年份:
    2015
  • 资助金额:
    $ 43.79万
  • 项目类别:
Dissecting the molecular basis and assembly of a complex morphological trait
剖析复杂形态特征的分子基础和组装
  • 批准号:
    8861499
  • 财政年份:
    2015
  • 资助金额:
    $ 43.79万
  • 项目类别:
Adaptive evolution of non coding DNA and gene expression divergence in Drosophila
果蝇非编码DNA的适应性进化和基因表达差异
  • 批准号:
    8514007
  • 财政年份:
    2009
  • 资助金额:
    $ 43.79万
  • 项目类别:
Adaptive evolution of non coding DNA and gene expression divergence in Drosophila
果蝇非编码DNA的适应性进化和基因表达差异
  • 批准号:
    8303418
  • 财政年份:
    2009
  • 资助金额:
    $ 43.79万
  • 项目类别:
Adaptive evolution of non coding DNA and gene expression divergence in Drosophila
果蝇非编码DNA的适应性进化和基因表达差异
  • 批准号:
    7920943
  • 财政年份:
    2009
  • 资助金额:
    $ 43.79万
  • 项目类别:
Adaptive evolution of non coding DNA and gene expression divergence in Drosophila
果蝇非编码DNA的适应性进化和基因表达差异
  • 批准号:
    8114194
  • 财政年份:
    2009
  • 资助金额:
    $ 43.79万
  • 项目类别:

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