Sources and Protracted Effects of Early Life Exposure to Arsenic and Mercury
生命早期接触砷和汞的来源和长期影响
基本信息
- 批准号:9921552
- 负责人:
- 金额:$ 266.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-04-01 至 2020-03-31
- 项目状态:已结题
- 来源:
- 关键词:Adverse effectsAgreementArabidopsisArsenicAttentionAwardBacterial InfectionsBangladeshBarker HypothesisBindingBioinformaticsBiologicalBreedingCarbonCarcinogensCardiovascular DiseasesChildChromosome MappingCognitiveCommunitiesConsensusConsumptionCountryDangerousnessDevelopmentDiabetes MellitusDietDiseaseDoseEcosystemEdible PlantsEnvironmentEnvironmental HealthExposure toFernsFetusFishesFluorescenceFoodFood SupplyFoundationsGenesGeneticGenetic VariationGeographic stateGoalsGrainHealthHealth PolicyHomeostasisHumanIndividualInfantInflammationInnate Immune ResponseInterdisciplinary StudyJuiceKnowledgeLanguageLeadLeadershipLegalLiquid substanceLungLung diseasesMalignant NeoplasmsMarinesMeasuresMemoryMercuryMetabolic syndromeMetalsMethylmercury CompoundsModelingMothersMotorMovementNervous system structureNewborn InfantOrganOryza sativaPlantsPlayPopulationPregnant WomenPrivatizationProblem SolvingProductionPsyche structurePterisPublic HealthPublicationsPublishingResearchResearch PersonnelResearch Project GrantsRiceRiskRisk AssessmentRoentgen RaysRoleSafetySalineScienceSeedsShellfishSignal Recognition ParticleSourceSuperfundSynchrotronsTechniquesTemperatureTestingThinkingTissuesToddlerToxinTrace ElementsTrainingTraining ProgramsTranslational ResearchVisuospatialWorkbasecareercontaminated seafoodcost effectivedevelopmental diseaseearly life exposureenvironmental changeenvironmental chemicalepidemiology studyexposed human populationfetalin uteroinnovationoffspringplant growth/developmentpreventprogramspublic health relevancereproductiveskillssuperfund siteuptakewell water
项目摘要
DESCRIPTION (provided by applicant)
The goal is to conduct innovative, multidisciplinary research to identify the major sources of As and Hg exposure and to elucidate the protracted effects of early life exposure to As and Hg on human health. The ATSDR has identified As and Hg as the number one and number three environmental chemicals of concern with regard to human health. As exposure in the young increases the rates of diabetes, respiratory disease, and reproductive and developmental disorders. Methylmercury (MeHg) is a major contaminant in the food supply, particularly fish. For fetuses, infants, and children, exposure to MeHg has severe, adverse effects on the developing nervous system and interferes with cognitive thinking and memory. Despite growing concern and increasing research focus on As and Hg, there are significant knowledge gaps, especially with regard to very low levels of exposure in the US. Accordingly, the Dartmouth SRP is dedicated to obtaining new information on the effects of exposure to very low levels of As and Hg and thereby provide a foundation for science-based risk assessment leading to more informed, effective and comprehensive public health policies. The specific aims are to: (1) Elucidate how As is taken up and accumulated in rice and to use this information to identify new rice cultivars that assimilate lower amounts of arsenic; (2) Elucidate how MeHg accumulates in fish and how environmental changes in temperature, salinity, and carbon content influences MeHg in marine ecosystems; (3) Identify the dose dependent and relative effects of inorganic and organic As on the innate immune response of the lung to bacterial infections; and (4) Understand the effects of maternal and fetal As exposure on the development of metabolic syndrome and inflammation in mothers and newborns, the most at risk in our population. The research will be supported by a Training Core, a Trace Elements Analysis Core, and the Research Translation and Community Engagement Cores that will communicate our research findings to our stakeholders and communities, respectively.
描述(由申请人提供)
目标是开展创新的多学科研究,以确定砷和汞暴露的主要来源,并阐明生命早期接触砷和汞对人类健康的长期影响。美国毒物和疾病登记署已将砷和汞确定为对人类健康造成影响的第一和第三大环境化学品。由于年轻人接触这种物质会增加糖尿病、呼吸道疾病以及生殖和发育障碍的发病率。甲基汞(MeHg)是食品供应中的主要污染物,特别是鱼类。对于胎儿、婴儿和儿童来说,接触甲基汞会对发育中的神经系统产生严重的不利影响,并干扰认知思维和记忆。尽管人们越来越关注砷和汞,研究也越来越多,但仍存在重大的知识差距,特别是在美国接触水平很低的情况下。 因此,达特茅斯SRP致力于获取有关接触极低水平砷和汞影响的新信息,从而为基于科学的风险评估提供基础,从而制定更明智、更有效和更全面的公共卫生政策。 具体目标是:(1)阐明水稻吸收和积累砷的方式,并利用这一信息确定吸收砷量较低的新水稻品种;(2)阐明甲基汞在鱼类体内的积累方式,以及温度、盐度和碳含量等环境变化如何影响海洋生态系统中的甲基汞;(3)确定无机砷和有机砷对肺对细菌感染的天然免疫反应的剂量依赖性和相对效应;(4)了解母亲和胎儿砷暴露对母亲和新生儿代谢综合征和炎症发展的影响,这是我们人群中最危险的。该研究将得到培训核心,微量元素分析核心以及研究翻译和社区参与核心的支持,这些核心将分别向我们的利益相关者和社区传达我们的研究结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Celia Y Chen其他文献
Celia Y Chen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Celia Y Chen', 18)}}的其他基金
Per- and Polyfluoroalkyl Substances (PFAS) in Marine Fish and Shellfish: A biomonitoring tool for PFAS remediation and a metric for potential human exposure through seafood consumption
海洋鱼类和贝类中的全氟烷基物质和多氟烷基物质 (PFAS):PFAS 修复的生物监测工具以及人类通过海鲜消费潜在接触的指标
- 批准号:
10399765 - 财政年份:2020
- 资助金额:
$ 266.96万 - 项目类别:
Per- and Polyfluoroalkyl Substances (PFAS) in Marine Fish and Shellfish: A biomonitoring tool for PFAS remediation and a metric for potential human exposure through seafood consumption
海洋鱼类和贝类中的全氟烷基物质和多氟烷基物质 (PFAS):PFAS 修复的生物监测工具以及人类通过海鲜消费潜在接触的指标
- 批准号:
10472968 - 财政年份:2020
- 资助金额:
$ 266.96万 - 项目类别:
Per- and Polyfluoroalkyl Substances (PFAS) in Marine Fish and Shellfish: A biomonitoring tool for PFAS remediation and a metric for potential human exposure through seafood consumption
海洋鱼类和贝类中的全氟烷基物质和多氟烷基物质 (PFAS):PFAS 修复的生物监测工具以及人类通过海鲜消费潜在接触的指标
- 批准号:
10064160 - 财政年份:2020
- 资助金额:
$ 266.96万 - 项目类别:
Per- and Polyfluoroalkyl Substances (PFAS) in Marine Fish and Shellfish: A biomonitoring tool for PFAS remediation and a metric for potential human exposure through seafood consumption
海洋鱼类和贝类中的全氟烷基物质和多氟烷基物质 (PFAS):PFAS 修复的生物监测工具以及人类通过海鲜消费潜在接触的指标
- 批准号:
10261496 - 财政年份:2020
- 资助金额:
$ 266.96万 - 项目类别:
Integrating Mercury Research and Policy in a Changing World
在不断变化的世界中整合汞研究和政策
- 批准号:
9326431 - 财政年份:2017
- 资助金额:
$ 266.96万 - 项目类别:
Collaborative on Food with Arsenic and Associated Risk and Regulation
含砷食品及相关风险和监管合作
- 批准号:
9052386 - 财政年份:2015
- 资助金额:
$ 266.96万 - 项目类别:
Climate impact on coastal ecosystem methylmercury: human exposure implications
气候对沿海生态系统甲基汞的影响:人类接触的影响
- 批准号:
8388569 - 财政年份:2012
- 资助金额:
$ 266.96万 - 项目类别:
Climate impact on coastal ecosystem methylmercury: human exposure implications
气候对沿海生态系统甲基汞的影响:人类接触的影响
- 批准号:
8705520 - 财政年份:2012
- 资助金额:
$ 266.96万 - 项目类别:
Climate impact on coastal ecosystem methylmercury: human exposure implications
气候对沿海生态系统甲基汞的影响:人类接触的影响
- 批准号:
8551668 - 财政年份:2012
- 资助金额:
$ 266.96万 - 项目类别:
相似海外基金
A study for cross borders Indonesian nurses and care workers: Case of Japan-Indonesia Economic Partnership Agreement
针对跨境印度尼西亚护士和护理人员的研究:日本-印度尼西亚经济伙伴关系协定的案例
- 批准号:
22KJ0334 - 财政年份:2023
- 资助金额:
$ 266.96万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Challenges of the Paris Agreement Exposed by the Energy Shift by External Factors: The Case of Renewable Energy Policies in Japan, the U.S., and the EU
外部因素导致的能源转移对《巴黎协定》的挑战:以日本、美国和欧盟的可再生能源政策为例
- 批准号:
23H00770 - 财政年份:2023
- 资助金额:
$ 266.96万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
NSF-NOAA Interagency Agreement (IAA) for the Global Oscillations Network Group (GONG)
NSF-NOAA 全球振荡网络组 (GONG) 机构间协议 (IAA)
- 批准号:
2410236 - 财政年份:2023
- 资助金额:
$ 266.96万 - 项目类别:
Cooperative Agreement
Conditions for U.S. Agreement on the Closure of Contested Overseas Bases: Relations of Threat, Alliance and Base Alternatives
美国关于关闭有争议的海外基地协议的条件:威胁、联盟和基地替代方案的关系
- 批准号:
23K18762 - 财政年份:2023
- 资助金额:
$ 266.96万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
MSI Smart Manufacturing Data Hub – Open Calls Grant Funding Agreement
MSI 智能制造数据中心 – 公开征集赠款资助协议
- 批准号:
900240 - 财政年份:2023
- 资助金额:
$ 266.96万 - 项目类别:
Collaborative R&D
Continuation of Cooperative Agreement between U.S. Food and Drug Administration and S.C. Department of Health and Environmental Control (DHEC) for MFRPS Maintenance.
美国食品和药物管理局与南卡罗来纳州健康与环境控制部 (DHEC) 继续签订 MFRPS 维护合作协议。
- 批准号:
10829529 - 财政年份:2023
- 资助金额:
$ 266.96万 - 项目类别:
National Ecological Observatory Network Governing Cooperative Agreement
国家生态观测站网络治理合作协议
- 批准号:
2346114 - 财政年份:2023
- 资助金额:
$ 266.96万 - 项目类别:
Cooperative Agreement
The Kansas Department of Agriculture's Flexible Funding Model Cooperative Agreement for MFRPS Maintenance, FPTF, and Special Project.
堪萨斯州农业部针对 MFRPS 维护、FPTF 和特别项目的灵活资助模式合作协议。
- 批准号:
10828588 - 财政年份:2023
- 资助金额:
$ 266.96万 - 项目类别:
Robust approaches for the analysis of agreement between clinical measurements: development of guidance and software tools for researchers
分析临床测量之间一致性的稳健方法:为研究人员开发指南和软件工具
- 批准号:
MR/X029301/1 - 财政年份:2023
- 资助金额:
$ 266.96万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Linguistic transfer in a contact variety of Spanish: Gender agreement production and attitudes
博士论文研究:西班牙语接触变体中的语言迁移:性别协议的产生和态度
- 批准号:
2234506 - 财政年份:2023
- 资助金额:
$ 266.96万 - 项目类别:
Standard Grant