Engineering highly elastic surgical sealants with hemostatic properties
设计具有止血特性的高弹性手术密封剂
基本信息
- 批准号:9918970
- 负责人:
- 金额:$ 72.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdhesionsAdhesivesAirAnastomosis - actionAnimal ModelAreaBindingBiocompatible MaterialsBloodBlood Coagulation FactorBlood VesselsBlood coagulationBody FluidsCardiovascular Surgical ProceduresChargeClinicClinicalConsumptionCyanoacrylatesDataDefectDevelopmentDevicesElastic TissueElasticityEngineeringEnvironmentExhibitsExtravasationFamily suidaeFibrin Tissue AdhesiveGoalsHemorrhageHemostatic AgentsHumanHydrogelsIn SituIn VitroInfectionIschemiaLightLiquid substanceLiverLungMechanicsMethodsModelingMovementMusOperative Surgical ProceduresPerformancePhysiologicalPleuralPolymersProceduresPropertyProteinsPunch BiopsyRecombinantsSilicatesSiteSurfaceSurgeonSurgical MeshSurgical complicationSurgical suturesSurgical woundSystemTechniquesThoracic Surgical ProceduresTimeTissuesToxic effectTropoelastinUltraviolet RaysVisible RadiationWorkbasebiomaterial compatibilitycell injurycrosslinkflexibilitygastrointestinalhealingimplantationimprovedin vivoin vivo evaluationinjurednanoparticlenovelphysical propertypressurepreventregenerativerepairedsealskillssoft tissuesurgery materialwoundwound closure
项目摘要
Project Summary/Abstract
Approximately 114 million surgical and procedure-based wounds occur annually worldwide, including 36 million
from surgery in the U.S. Damages to delicate soft tissues, such as lung, liver, and blood vessels, are particularly
challenging to repair. When these tissues are punched for biopsy or injured during procedures, they must be
reconnected surgically using sutures, staples, or implantation of surgical meshes. Despite their common use in
clinics, these mechanical methods are associated with inevitable tissue damages caused by deep piercing and
ischemia. These methods are also time-consuming, demand surgeon's skills during the surgeries, and might
cause post-surgical complications such as infection. To resolve these issues, various types of surgical materials
have been used for sealing, reconnecting tissues, or attaching devices to tissues. Despite the emergence of
several surgical sealants, the biomaterials used as sealants/adhesives often have some drawbacks that limit
their applications, such as low mechanical flexibility, toxicity effects or toxic degradation products, poor adhesive
strength, and inability to control bleeding. Therefore, none of them meet all the necessary needs to replace
sutures and staples. An ideal surgical sealant is required to be flexible to adapt with dynamic movement of native
tissues, have excellent biocompatibility and controlled biodegradability, provide high adhesive strength and burst
pressure particularly in the presence of body fluids, and demonstrate hemostatic properties to prevent extensive
blood loss. In this proposal, we aim to engineer a novel, highly adhesive and hemostatic hydrogel-based surgical
sealant from a visible light activated, modified recombinant human protein methacryloyl tropoelastin (MeTro) and
hemostatic silicate nanoparticles (SNs). We will physically blend the engineered MeTro hydrogels with SNs to
form MeTro/SN composite hydrogels with highly adhesion and enhanced hemostatic performance. We will then
evaluate the function of the engineered surgical material as a hemostatic sealant in both small and large animal
models. Our preliminary data suggests that this material is superior to the existing products in the market and
may generate a paradigm-shifting surgical material that may not require sutures due to its superior mechanical,
adhesive, and hemostatic properties. The engineered highly adhesive and hemostatic surgical sealant can be
potentially used to stop air leakages after lung surgery and also support new tissue formation to repair the
defected sites. Due to the highly tunable properties of the engineered composite hydrogels, it is expected that
this system can also be used in various procedures such as anastomoses, cardiovascular surgeries, and wound
closure.
项目总结/文摘
项目成果
期刊论文数量(0)
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Nasim Annabi其他文献
Nasim Annabi的其他文献
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{{ truncateString('Nasim Annabi', 18)}}的其他基金
Engineering highly elastic surgical sealants with hemostatic properties
设计具有止血特性的高弹性手术密封剂
- 批准号:
10089283 - 财政年份:2018
- 资助金额:
$ 72.52万 - 项目类别:
Engineering a naturally derived and highly adhesive surgical sealant
设计一种天然衍生的高粘合性手术密封剂
- 批准号:
9920717 - 财政年份:2018
- 资助金额:
$ 72.52万 - 项目类别:
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