High resolution volumetric MRI for prostate cancer active surveillance

高分辨率体积 MRI 用于前列腺癌主动监测

• 批准号: 9919515
• 负责人: HYUNG L KIM
• 金额: $ 38.02万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9919515
• 关键词: 3-Dimensional; Area; Biopsy; Cancer Etiology; Cessation of life; Characteristics; Clinical; Clinical Trials; Computer software; Data; Data Set; Detection; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; Echo-Planar Imaging; Enrollment; Erectile dysfunction; Feedback; Hemorrhage; Histologic; Hospitalization; Image; Lead; Lesion; Life; Local Therapy; Magnetic Resonance Imaging; Magnetism; Malignant neoplasm of prostate; Modality; Modernization; Molecular; Monitor; Morphologic artifacts; Motion; Newly Diagnosed; Noise; Operative Surgical Procedures; Organ; Pain; Pathology; Patients; Predisposition; Prostate Cancer therapy; Prostatic Neoplasms; Protocols documentation; Public Health; Quality of life; Radiation; Radiation therapy; Radical Prostatectomy; Reproducibility; Resolution; Risk; Sampling; Sampling Errors; Scanning; Scheme; Sepsis; Signal Transduction; System; Techniques; Testing; Three-Dimensional Imaging; Time; Tumor stage; Ultrasonography; Update; Urinary Incontinence; anatomic imaging; cancer imaging; cost; curative treatments; data acquisition; disorder risk; follow-up; healthy volunteer; imaging modality; improved; men; novel; prospective; prostate biopsy; prostate cancer progression; side effect; surveillance strategy; tumor; tumor ablation; tumor growth

PROJECT SUMMARY The vast majority of men diagnosed with prostate cancer do not die of their disease and can choose to delay or avoid surgical or radiation treatment by undergoing active surveillance. Unfortunately, men on active surveillance remain at risk for progression of prostate cancer and even death from prostate cancer. Therefore, men are carefully followed with transrectal prostate biopsies every 1-2 years. Unlike with tumors in other organs, there is no imaging modality that can be used to accurately detect and monitor prostate tumors. Furthermore, prostate biopsies are painful and associated with a significant risk of sepsis and hospitalization. Therefore, the personal and public health burden of life-long active surveillance is significant. We introduce a novel MRI sequence that improves image quality and resolution. Our preliminary data shows that in men on active surveillance, standard MRI detects only 61% of biopsy-proven prostate tumors. However, our novel HR- MRI detects nearly all (96%) biopsy-proven prostate tumors, which is iimpressive since men on active surveillance tend to have small, low grade tumors. Our HR-MRI used to generate our preliminary data had a 5-fold improvement in resolution; however, the resolution can be improved up to 25-fold at a cost of increased scan time. The first aim will be to further optimize our HR-MRI to improve resolution and image quality while minimizing the scan time. The optimized HR-MRI will be used to detect changes in tumor size or grade in men on active surveillance and consider the possibiity that tumor growth rate or other imaging characteristics predict the risk of disease progression. A more accurate MRI modality for localizing and monitoring prostate tumors will allow men on active surveillance to reduce the number of followup biopsies, identify tumors for biopsies that can be used for molecular characterization, and localize tumors for focal ablative therapies. The HR-MRI can be deployed on existing 1.5T and 3T MRI systems with a simple software installation and does not require new hardware.

项目摘要 绝大多数被诊断患有前列腺癌的男性不会死于疾病，可以选择延迟或 通过进行主动监测来避免手术或辐射治疗。不幸的是，有活跃的男人 监测仍然有前列腺癌进展，甚至前列腺癌死亡的风险。所以， 每1 - 2年就仔细地接受经直肠前列腺活检。与其他肿瘤不同 器官，没有成像方式可用于准确检测和监测前列腺肿瘤。 此外，前列腺活检是痛苦的，并且与败血症和住院的重大风险相关。 因此，终身积极监视的个人和公共卫生负担很大。我们介绍一个 新颖的MRI序列可改善图像质量和分辨率。我们的初步数据表明，在男性中 主动监视，标准MRI仅检测到活检证实的前列腺肿瘤的61％。但是，我们的小说HR- MRI检测到几乎所有（96％）活检证实的前列腺肿瘤，这是我的令人印象深刻的 监测往往具有小的低级肿瘤。我们的HR-MRI用于生成我们的初步数据 分辨率提高了5倍；但是，该分辨率最多可提高25倍，成本增加 扫描时间。第一个目的是进一步优化我们的HR-MRI以提高分辨率和图像质量，同时 最小化扫描时间。优化的HR-MRI将用于检测男性肿瘤大小或成绩的变化 在主动监视方面，并考虑肿瘤生长速率或其他成像特征的可能性 预测疾病进展的风险。用于定位和监测前列腺的更准确的MRI方式 肿瘤将使男性进行主动监视，以减少随访活检的数量，确定肿瘤 可用于分子表征的活检，并将肿瘤定位用于局灶性消融疗法。这 可以将HR-MRI部署在现有的1.5T和3T MRI系统中，并具有简单的软件安装，并且可以 不需要新的硬件。