Training in Research Program on Alcohol Use by Persons with our at Risk for HIV

艾滋病毒高危人群饮酒研究项目培训

• 批准号: 9918815
• 负责人: JUDITH ALISSA HAHN
• 金额: $ 19.73万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9918815
• 关键词: Adolescent; Affect; Age; Agreement; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Atrial Fibrillation; Attitude; Biological; Biological Factors; Biological Markers; Biosensor; Body mass index; Cessation of life; Characteristics; Chronic; Consensus; Data; Data Pooling; Data Sources; Drug Metabolic Detoxication; Ethanol; Ethanol Metabolism; Ethnic Origin; Face; Funding; Gender; Geographic Locations; Glucuronides; Goals; Gold; Grant; HIV; HIV Infections; HIV risk; Health; Heart; Heavy Drinking; Holidays; Immunoassay; Infant; Intervention; Intervention Studies; Investigation; Judgment; Knowledge; Laboratories; Measurement; Measures; Mentored Research Scientist Development Award; Mentors; Minority Groups; Monitor; Observational Study; Outcome; Outcome Measure; Participant; Patient Self-Report; Pattern; Persons; Pilot Projects; Population; Population Heterogeneity; Publications; Publishing; Race; Reporting; Research; Research Personnel; Research Support; Resources; Risk; Risk Factors; Role; Sample Size; Scientist; Sensitivity and Specificity; Social Desirability; Specificity; Standardization; Testing; Time; Training; Tuberculosis; Underrepresented Minority; Underrepresented Populations; Urine; Validation; Viral hepatitis; Vulnerable Populations; Woman; aged; alcohol intervention; alcohol measurement; alcohol monitoring; alcohol testing; binge drinking; clinical encounter; clinical practice; comorbidity; contingency management; cost; disability; drinking; experience; hazardous drinking; high risk; improved; incentive-based intervention; intimate partner violence; new technology; novel; phosphatidylethanol; pill; point of care; premature; programs; public health relevance; screening; sex; success; temporal measurement; tool; transmission process

Abstract I am requesting funding for a 5-year renewal of K24 AA022586, “Training and Research Program on Alcohol use by Persons with or At-Risk for HIV”. Over this initial K24 funding period, my research program has flourished, progressing from observational studies of alcohol's impact on HIV risk and outcomes to alcohol intervention studies via new U01 and R01 funding. These studies leverage alcohol biomarkers (phosphatidylethanol – PEth and ethyl glucuronide – EtG) and biosensors that regularly monitor alcohol in sweat (transdermal alcohol) as objective outcome measures and as intervention tools (for incentive-based interventions). My mentees have also achieved success during this period in publishing (41 mentee first- authored publications) and grant funding (8 awards for K01, R36, R34, R01, and U01 proposals). I propose to renew this K24 funding to build upon this research and mentoring success in two new ways. (1) I propose to expand my alcohol/HIV research mentoring by including training in the use of alcohol biomarkers and biosensors. This includes mentoring scholars to study alcohol measurement via biomarkers or biosensors (e.g. exploring combinations of biomarkers with biosensors, examining biosensor and point-of-care biomarker use in the real world, etc.). It also includes mentoring investigators conducting research in HIV comorbidities (e.g. tuberculosis, viral hepatitis, polysubstance use) and in vulnerable populations (i.e. adolescents, infants of HIV- infected women, those experiencing intimate partner violence) to incorporate the role of alcohol use into their research, using biomarkers or biosensors. To facilitate these expansions to my mentoring, I will use K24 renewal funds for biomarkers and biosensors for mentee-led pilot projects. (2) I propose to take deliberate steps to increase mentoring of persons who identify as under-represented minorities (URM) thereby expanding the workforce of HIV researchers from populations that are disproportionately affected by substance use (including alcohol) and HIV. The proposed K24 research component will leverage valuable data sources to give mentees biomarker and biosensor research experience. These will be (1) pooling data from several alcohol studies with over 5000 participants with PEth testing, to examine correlates of PEth positivity, optimal cutoffs, and moderators; (2) leveraging data from drinkers wearing alcohol biosensors for 28 days, to further examine PEth cutoffs, and (3) examining correlates of test positivity of a of low-cost, point-of-care urine EtG test in a current study of hazardous drinkers. To be maximally effective as both a research leader and a mentor, I propose additional training to be at the forefront of the rapidly evolving alcohol biomarker/biosensor fields, and also training to be a culturally responsive mentor for persons who identify as URM. In summary, this K24-supported research and mentor training will grow the alcohol/HIV research field by proving training in alcohol biomarker/biosensor tools and applying them to alcohol/HIV issues, and by prioritizing training for scientists from URM groups that are disproportionately affected by alcohol and HIV.

摘要我要求为K24 AA022586的5年续签提供资金，“培训与研究计划 在此最初的K24资金期间，我的研究计划有饮酒或高危艾滋病毒的饮酒。 蓬勃发展，从对酒精对艾滋病毒风险的影响和结果的观察性研究发展为酒精 通过新的U01和R01资金进行干预研究。这些研究利用酒精生物标志物 （磷脂酰乙醇 - Peth和乙基糖苷 - ETG）和生物传感器，并定期监测酒精 汗水（透皮酒精）作为客观结果指标和干预工具（用于基于激励的工具 干预措施）。在此期间，我的Menees在出版期间也取得了成功（41个Menee首先 - 撰写了出版物）和赠款（授予K01，R36，R34，R01和U01提案的8个奖项）。我建议 续签这项K24的资金以两种新方式以这项研究和心理成功为基础。 （1）我建议 通过包括在使用酒精生物标志物和 生物传感器。这包括通过生物标志物或生物传感器研究酒精测量的心理学者（例如 探索生物标志物与生物标志物的组合，检查生物标志物和护理生物标志物的使用 现实世界等）。它还包括进行HIV合并症研究的心理研究人员（例如 结核病，病毒性肝炎，多物质使用）和脆弱人群（即青少年，HIV-婴儿 感染妇女，那些经历亲密伴侣暴力的人）将酒精使用的作用纳入其 研究，使用生物标志物或生物传感器。为了促进这些扩展到我的心理，我将使用K24 为由导师领导的飞行员项目的生物标志物和生物传感器的更新资金。 （2）我提议故意 提高确定代表性不足的少数民族（URM）的人的心理步骤，从而扩大 来自人群的艾滋病毒研究人员的劳动力受到药物使用影响不成比例的 （包括酒精）和艾滋病毒。拟议的K24研究组件将利用有价值的数据源 为导师生物标志物和生物传感器研究经验。这些将是（1）从几个 与5000多名参与者进行Peth测试的酒精研究，以检查Peth阳性的相关性，最佳 截止器和主持人； （2）利用饮酒者的数据，穿着酒精生物传感器28天，以进一步 检查Peth的截止值，（3）检查低成本，护理尿液ETG的测试潜力的相关性 在当前对危险饮酒者的研究中进行测试。作为研究领导者和 导师，我建议其他培训处于快速发展的酒精生物标志物/生物传感器的最前沿 田野，还训练成为一名具有文化反应的导师，适合那些确定为URM的人。总而言之，这 K24支持的研究和心理培训将通过提供培训来扩大酒精/艾滋病毒研究领域 酒精生物标志物/生物传感器工具，并将其应用于酒精/艾滋病毒问题，并优先考虑 来自URM群体的科学家受到酒精和艾滋病毒的影响不成比例。