Mentoring Multidisciplinary Patient-Oriented Research in Liver Disease

指导肝病多学科、以患者为导向的研究

• 批准号: 9918814
• 负责人: Mandana Khalili
• 金额: $ 19.35万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9918814
• 关键词: Adipose tissue; Adverse effects; Affect; Alcohol consumption; Alcohols; Attenuated; Award; Chronic Hepatitis C; Clinical; Clinical Investigator; Clinical Sciences; Complex; Data; Diabetes Mellitus; Discipline; Disease Outcome; Dose; Environment; Environmental Risk Factor; Ethanol Metabolism; Evaluation; Extramural Activities; Fatty Liver; Fatty acid glycerol esters; Functional disorder; Funding; General Population; Goals; Health; Hepatic; Hepatitis C; Hepatitis C Therapy; High Prevalence; Human; Individual; Infection; Institutes; Insulin; Insulin Resistance; Interdisciplinary Study; Investigation; Latino; Lead; Leadership; Lipolysis; Liver; Liver Fibrosis; Liver diseases; Measurement; Measures; Mentors; Mentorship; Metabolic; Metabolism; Modeling; Muscle; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Organ; Outcome; Pathogenesis; Patients; Peripheral; Persons; Population; Populations at Risk; Preventive Intervention; Primary carcinoma of the liver cells; Productivity; Recommendation; Research; Research Activity; Research Personnel; Resources; Risk; Risk Factors; Role; Science; Self Efficacy; Surrogate Markers; Testing; Training; Training Programs; Translational Research; Underrepresented Groups; United States; United States National Institutes of Health; Viral; Viral Load result; Viral hepatitis; Virus; adverse outcome; alcohol effect; anti-hepatitis C; career; career development; chronic alcohol ingestion; chronic liver disease; cofactor; cohort; diabetes control; diabetes risk; drinking; effectiveness research; glucose metabolism; high risk drinking; high risk population; improved; indexing; insight; insulin secretion; insulin signaling; lipid metabolism; liver inflammation; multidisciplinary; non-alcoholic fatty liver disease; non-diabetic; patient oriented; patient oriented research; prevent; problem drinker; programs; recruit; screening; success; training opportunity

Abstract Dr. Khalili is an established investigator and mentor as evidenced by her high-quality patient-oriented research, mentoring activities of young investigators, and her institutional leadership roles in research mentoring. Her long-term career objectives are: 1) to support and train early clinical investigators to transition to independent careers in multidisciplinary research, 2) to enhance effectiveness of research mentors to better meet the needs of their mentees, and 3) to lead efforts in better understanding of mechanisms of host and environmental interactions important to pathogenesis and progression of liver disease. During the next project period, she will use initial successes of the last project period to further expand her research and mentoring program, thereby increasing the pool of new investigators that successfully transition to independence. Dr. Khalili's multidisciplinary research program supported by continuous extramural funding will serve as the platform for providing mentorship for junior investigators from different disciplines. Moreover, she plans to lead national training efforts to enhance research mentor and mentee self-efficacy and mentee productivity especially among underrepresented groups in biomedical sciences. In the next project cycle she will capitalize on the rich academic environment of UCSF and its Clinical and Translational Sciences Institute resources to train mentees from different disciplines to enable them to compete successfully for mentored career development and independent awards in patient-oriented research. While the value of mentoring has been well-established, better understanding of which components of mentoring are most impactful on mentee success and implementing these strategies in training mentors are also critical to their young investigator career development. Dr. Khalili will use her leadership role in the UCSF Mentor Training Program to advance mentor training approaches through evaluation and program enhancement that build capacity of research mentors to effectively mentor young investigators and especially those from underrepresented backgrounds. Insulin resistance is an important contributor to negative impact of chronic liver diseases on human health and adipose tissue dysfunction has emerged as important to pathogenesis of liver disease. During the first project period, we gained insights into host, alcohol, and viral interactions influencing pathogenesis of abnormal glucose metabolism. The research plan for the next project period will extend these investigations to evaluate the influence of alcohol on adipose-tissue liver axis using chronic hepatitis C as a model of a common liver disease with high rates of adverse metabolic outcomes and in utilizing validated and direct measurements of insulin resistance in adipose tissue in at-risk populations. This research plan and resources from Dr. Khalili's ongoing research activities will provide mentoring and training opportunities for new and junior clinical investigators in patient-oriented multidisciplinary research in liver disease. The continuation of this award will allow Dr. Khalili to achieve these mentorship and research goals.

抽象的 Khalili 博士是一位知名的研究者和导师，她以患者为中心的高质量就证明了这一点。 研究、年轻研究者的指导活动以及她在研究中的机构领导作用 指导。她的长期职业目标是：1）支持和培训早期临床研究人员过渡 多学科研究的独立职业，2）提高研究导师的有效性 更好地满足受训者的需求，以及 3) 领导更好地理解东道国机制的努力 和环境的相互作用对肝病的发病机制和进展很重要。在接下来的时间里 在项目期间，她将利用上一个项目期间的初步成功来进一步扩展她的研究和 指导计划，从而增加了成功过渡到的新研究人员的数量 独立。 Khalili 博士的多学科研究项目得到持续的校外资助的支持 将作为为来自不同学科的初级研究人员提供指导的平台。而且， 她计划领导国家培训工作，以提高研究导师和受训者的自我效能和受训者 生产力，尤其是生物医学领域代表性不足的群体。在下一个项目周期中她 将利用加州大学旧金山分校及其临床和转化科学研究所丰富的学术环境 培训来自不同学科的学员的资源，使他们能够成功竞争指导 以患者为导向的研究中的职业发展和独立奖项。虽然指导的价值已经 已经完善，更好地了解指导的哪些组成部分对受指导者影响最大 培训导师的成功和实施这些策略对于年轻的研究者也至关重要 职业发展。卡利利博士将利用她在加州大学旧金山分校导师培训计划中的领导作用来推进 通过评估和项目强化来指导培训方法，以建设研究能力 导师有效地指导年轻的研究人员，特别是那些来自代表性不足的背景的研究人员。 胰岛素抵抗是慢性肝病对人类健康产生负面影响的重要因素 脂肪组织功能障碍已成为肝病发病机制的重要组成部分。第一次期间 在项目期间，我们深入了解了宿主、酒精和病毒之间的相互作用，影响了疾病的发病机制 糖代谢异常。下一个项目期的研究计划将扩展这些调查 使用慢性丙型肝炎作为模型来评估酒精对脂肪组织肝轴的影响 常见的肝病具有很高的不良代谢结果发生率，并且利用经过验证的直接方法 测量高危人群脂肪组织中的胰岛素抵抗。本研究计划和资源 卡利利博士正在进行的研究活动将为新的和 以患者为导向的肝病多学科研究的初级临床研究者。的延续 该奖项将使哈利利博士能够实现这些指导和研究目标。