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Mentoring Multidisciplinary Patient-Oriented Research in Liver Disease

指导肝病多学科、以患者为导向的研究

基本信息

批准号：
10619440
负责人：
Mandana Khalili
金额：
$ 19.35万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10619440
关键词：
Adipose tissue Adverse effects Affect Alcohol consumption Alcoholic Fatty Liver Alcoholic Hepatitis Alcohols American Attenuated Award Chronic Hepatitis C Clinical Clinical Investigator Clinical Sciences Complex Data Diabetes Mellitus Discipline Disease Outcome Dose Environment Environmental Risk Factor Evaluation Extramural Activities Fatty Liver Fatty acid glycerol esters Fibrosis Functional disorder Funding General Population Goals Health Hepatic Hepatitis C Hepatitis C Therapy High Prevalence Human Individual Infection Institution Insulin Insulin Resistance Insulin Signaling Pathway Interdisciplinary Study Investigation Latino Population Lead Leadership Lipolysis Liver Liver Fibrosis Liver diseases Measurement Measures Mentors Mentorship Metabolic Metabolism Modeling Muscle Non-Insulin-Dependent Diabetes Mellitus Obesity Organ Outcome Pathogenesis Patients Peripheral Persons Population Populations at Risk Primary carcinoma of the liver cells Productivity Recommendation Research Research Activity Research Personnel Resources Risk Risk Factors Role Science Self Efficacy Surrogate Markers Testing Training Training Programs Translational Research Underrepresented Populations United States United States National Institutes of Health Viral Viral Load result Viral hepatitis Virus adverse outcome alcohol effect anti-hepatitis C career career development chronic alcohol ingestion chronic liver disease cofactor cohort diabetes control diabetes risk drinking effectiveness research glucose metabolism high risk drinking high risk population improved indexing insight insulin secretion lipid metabolism liver inflammation multidisciplinary non-alcoholic fatty liver disease non-diabetic patient oriented patient oriented research prevent preventive intervention programs recruit screening success training opportunity

项目摘要

Abstract Dr. Khalili is an established investigator and mentor as evidenced by her high-quality patient-oriented research, mentoring activities of young investigators, and her institutional leadership roles in research mentoring. Her long-term career objectives are: 1) to support and train early clinical investigators to transition to independent careers in multidisciplinary research, 2) to enhance effectiveness of research mentors to better meet the needs of their mentees, and 3) to lead efforts in better understanding of mechanisms of host and environmental interactions important to pathogenesis and progression of liver disease. During the next project period, she will use initial successes of the last project period to further expand her research and mentoring program, thereby increasing the pool of new investigators that successfully transition to independence. Dr. Khalili's multidisciplinary research program supported by continuous extramural funding will serve as the platform for providing mentorship for junior investigators from different disciplines. Moreover, she plans to lead national training efforts to enhance research mentor and mentee self-efficacy and mentee productivity especially among underrepresented groups in biomedical sciences. In the next project cycle she will capitalize on the rich academic environment of UCSF and its Clinical and Translational Sciences Institute resources to train mentees from different disciplines to enable them to compete successfully for mentored career development and independent awards in patient-oriented research. While the value of mentoring has been well-established, better understanding of which components of mentoring are most impactful on mentee success and implementing these strategies in training mentors are also critical to their young investigator career development. Dr. Khalili will use her leadership role in the UCSF Mentor Training Program to advance mentor training approaches through evaluation and program enhancement that build capacity of research mentors to effectively mentor young investigators and especially those from underrepresented backgrounds. Insulin resistance is an important contributor to negative impact of chronic liver diseases on human health and adipose tissue dysfunction has emerged as important to pathogenesis of liver disease. During the first project period, we gained insights into host, alcohol, and viral interactions influencing pathogenesis of abnormal glucose metabolism. The research plan for the next project period will extend these investigations to evaluate the influence of alcohol on adipose-tissue liver axis using chronic hepatitis C as a model of a common liver disease with high rates of adverse metabolic outcomes and in utilizing validated and direct measurements of insulin resistance in adipose tissue in at-risk populations. This research plan and resources from Dr. Khalili's ongoing research activities will provide mentoring and training opportunities for new and junior clinical investigators in patient-oriented multidisciplinary research in liver disease. The continuation of this award will allow Dr. Khalili to achieve these mentorship and research goals.

摘要哈利利博士是一位公认的研究员和导师，她以病人为导向的高质量证明了这一点。年轻研究人员的研究、指导活动以及她在研究中的机构领导作用辅导。她的长期职业目标是：1)支持和培训早期临床研究人员过渡到多学科研究的独立职业，2)提高研究导师的有效性，以更好地满足学员的需求，以及3)领导更好地了解东道国机制的努力环境的相互作用对肝病的发生和发展很重要。在下一次在项目期间，她将利用上一个项目期间的初步成功来进一步扩大她的研究和指导计划，从而增加成功过渡到独立。哈利利博士的多学科研究计划得到持续的外部资助将作为为来自不同学科的初级调查人员提供指导的平台。此外，她计划领导全国培训工作，以提高研究导师和学员的自我效能和学员生产力，特别是在生物医学科学中代表性不足的群体中。在下一个项目周期中，她将利用加州大学旧金山分校及其临床和翻译科学研究所丰富的学术环境培训来自不同学科的学员的资源，使他们能够成功竞争学员以病人为中心的研究中的职业发展和独立奖项。虽然指导的价值在于已经确立，更好地了解指导的哪些组成部分对被辅导者影响最大成功并在培训导师时实施这些策略对他们的年轻研究员来说也是至关重要的职业发展。哈利利博士将利用她在加州大学旧金山分校导师培训计划中的领导作用通过评估和计划增强来指导培训方法，以建设研究能力导师有效地指导年轻的调查人员，特别是那些来自代表性不足的背景的人。胰岛素抵抗是慢性肝病对人类健康负面影响的重要因素脂肪组织功能障碍已成为肝病发病机制中的重要因素。在第一次在项目期间，我们深入了解了宿主、酒精和病毒相互作用对致病机制的影响糖代谢异常。下一个项目期的研究计划将延长这些调查以慢性丙型肝炎为模型评价酒精对脂肪组织肝轴的影响常见肝病，不良代谢结果发生率高，使用有效和直接高危人群脂肪组织中胰岛素抵抗的测量。本研究计划和资源来自Khalili博士正在进行的研究活动将为新的和以病人为中心的肝病多学科研究的初级临床研究人员。的延续该奖项将使哈利利博士能够实现这些指导和研究目标。