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Mentoring Multidisciplinary Patient-Oriented Research in Liver Disease

指导肝病多学科、以患者为导向的研究

基本信息

批准号：
10619440
负责人：
Mandana Khalili
金额：
$ 19.35万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10619440
关键词：
Adipose tissue Adverse effects Affect Alcohol consumption Alcoholic Fatty Liver Alcoholic Hepatitis Alcohols American Attenuated Award Chronic Hepatitis C Clinical Clinical Investigator Clinical Sciences Complex Data Diabetes Mellitus Discipline Disease Outcome Dose Environment Environmental Risk Factor Evaluation Extramural Activities Fatty Liver Fatty acid glycerol esters Fibrosis Functional disorder Funding General Population Goals Health Hepatic Hepatitis C Hepatitis C Therapy High Prevalence Human Individual Infection Institution Insulin Insulin Resistance Insulin Signaling Pathway Interdisciplinary Study Investigation Latino Population Lead Leadership Lipolysis Liver Liver Fibrosis Liver diseases Measurement Measures Mentors Mentorship Metabolic Metabolism Modeling Muscle Non-Insulin-Dependent Diabetes Mellitus Obesity Organ Outcome Pathogenesis Patients Peripheral Persons Population Populations at Risk Primary carcinoma of the liver cells Productivity Recommendation Research Research Activity Research Personnel Resources Risk Risk Factors Role Science Self Efficacy Surrogate Markers Testing Training Training Programs Translational Research Underrepresented Populations United States United States National Institutes of Health Viral Viral Load result Viral hepatitis Virus adverse outcome alcohol effect anti-hepatitis C career career development chronic alcohol ingestion chronic liver disease cofactor cohort diabetes control diabetes risk drinking effectiveness research glucose metabolism high risk drinking high risk population improved indexing insight insulin secretion lipid metabolism liver inflammation multidisciplinary non-alcoholic fatty liver disease non-diabetic patient oriented patient oriented research prevent preventive intervention programs recruit screening success training opportunity

项目摘要

Abstract Dr. Khalili is an established investigator and mentor as evidenced by her high-quality patient-oriented research, mentoring activities of young investigators, and her institutional leadership roles in research mentoring. Her long-term career objectives are: 1) to support and train early clinical investigators to transition to independent careers in multidisciplinary research, 2) to enhance effectiveness of research mentors to better meet the needs of their mentees, and 3) to lead efforts in better understanding of mechanisms of host and environmental interactions important to pathogenesis and progression of liver disease. During the next project period, she will use initial successes of the last project period to further expand her research and mentoring program, thereby increasing the pool of new investigators that successfully transition to independence. Dr. Khalili's multidisciplinary research program supported by continuous extramural funding will serve as the platform for providing mentorship for junior investigators from different disciplines. Moreover, she plans to lead national training efforts to enhance research mentor and mentee self-efficacy and mentee productivity especially among underrepresented groups in biomedical sciences. In the next project cycle she will capitalize on the rich academic environment of UCSF and its Clinical and Translational Sciences Institute resources to train mentees from different disciplines to enable them to compete successfully for mentored career development and independent awards in patient-oriented research. While the value of mentoring has been well-established, better understanding of which components of mentoring are most impactful on mentee success and implementing these strategies in training mentors are also critical to their young investigator career development. Dr. Khalili will use her leadership role in the UCSF Mentor Training Program to advance mentor training approaches through evaluation and program enhancement that build capacity of research mentors to effectively mentor young investigators and especially those from underrepresented backgrounds. Insulin resistance is an important contributor to negative impact of chronic liver diseases on human health and adipose tissue dysfunction has emerged as important to pathogenesis of liver disease. During the first project period, we gained insights into host, alcohol, and viral interactions influencing pathogenesis of abnormal glucose metabolism. The research plan for the next project period will extend these investigations to evaluate the influence of alcohol on adipose-tissue liver axis using chronic hepatitis C as a model of a common liver disease with high rates of adverse metabolic outcomes and in utilizing validated and direct measurements of insulin resistance in adipose tissue in at-risk populations. This research plan and resources from Dr. Khalili's ongoing research activities will provide mentoring and training opportunities for new and junior clinical investigators in patient-oriented multidisciplinary research in liver disease. The continuation of this award will allow Dr. Khalili to achieve these mentorship and research goals.

摘要博士哈利利是一个既定的研究者和导师，她的高质量的以病人为导向的证明，研究，指导年轻研究人员的活动，以及她在研究中的机构领导作用指导。她的长期职业目标是：1）支持和培训早期临床研究者过渡在多学科研究中的独立职业，2）提高研究导师的有效性，更好地满足学员的需求，以及3）领导努力，更好地了解东道国的机制和环境相互作用对肝病的发病机制和进展很重要。在下一个项目期间，她将利用上一个项目期间的初步成功，进一步扩大她的研究，指导计划，从而增加成功过渡到独立哈利利博士的多学科研究计划得到持续的校外资金支持将作为平台，为来自不同学科的初级调查员提供导师。此外，委员会认为，她计划领导国家培训工作，以提高研究导师和学员的自我效能，特别是在生物医学科学中代表性不足的群体中。在下一个项目周期，我将利用加州大学旧金山分校及其临床和转化科学研究所丰富的学术环境资源，以培训来自不同学科的学员，使他们能够成功地竞争职业发展和面向患者的研究中的独立奖项。虽然指导的价值已经建立，更好地了解指导的哪些组成部分对学员最有影响在培训导师过程中成功实施这些策略对年轻的研究人员也至关重要职业发展。哈利利博士将利用她在UCSF导师培训计划中的领导作用，通过评估和加强项目来建立研究能力的导师培训方法导师，以有效地指导年轻的调查人员，特别是那些来自代表性不足的背景。胰岛素抵抗是慢性肝病对人类健康产生负面影响的重要因素脂肪组织功能障碍已经成为肝病发病机制的重要因素。在第一在项目期间，我们深入了解了宿主，酒精和病毒相互作用对疾病发病机制的影响。糖代谢异常下一个项目期间的研究计划将延长这些调查以慢性丙型肝炎为模型，评价酒精对脂肪组织肝轴的影响。常见肝脏疾病的不良代谢结果发生率很高，并且使用经过验证和直接的测量高危人群脂肪组织中的胰岛素抵抗。这项研究计划和资源哈利利博士正在进行的研究活动将提供指导和培训机会，初级临床研究人员在以患者为导向的多学科研究肝病。的延续该奖项将使哈利利博士实现这些指导和研究目标。