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Mentoring Multidisciplinary Patient-Oriented Research in Viral Hepatitis

指导病毒性肝炎的多学科、以患者为导向的研究

基本信息

批准号：
8495606
负责人：
Mandana Khalili
金额：
$ 18.01万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8495606
关键词：
Affect Age Alcohol consumption Alcohols American Antiviral Therapy Area Attenuated Award California Clinical Investigator Clinical Research Clinical Sciences Clinical Trials Commit Complex Data Diabetes Mellitus Diabetes prevention Disease Environment Environmental Risk Factor Extrahepatic Extramural Activities Family history of Functional disorder Funding General Population Glucose Intolerance Goals Health Hepatitis C Hepatitis C virus Impairment Incidence Individual Infection Institutes Insulin Insulin Resistance Insulin Signaling Pathway Integration Host Factors Interdisciplinary Study K-Series Research Career Programs Knowledge Latino Leadership Liver diseases Measurement Measures Mediating Medicine Mentors Mentorship Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Pathogenesis Patients Peripheral Persons Physiological Population Populations at Risk Prevention Preventive Intervention Productivity Public Health Recruitment Activity Research Research Activity Research Personnel Research Training Resources Risk Risk Factors Role SECTM1 gene San Francisco Shapes Staging Time Training Training Support Translational Research United States United States National Institutes of Health Universities Viral Viral hepatitis alcohol effect base career career development chronic liver disease diabetes risk drinking experience glucose metabolism glucose uptake improved insight insulin secretion insulin sensitivity liver transplantation multidisciplinary non-diabetic patient oriented patient oriented research predictive modeling professor programs public health relevance response

项目摘要

DESCRIPTION (provided by applicant): Dr. Mandana Khalili is an Associate Professor of Medicine at the University of California, San Francisco (UCSF). Her long-term career objectives are to mentor early clinical investigators committed to patient-oriented research and to become a leader in efforts to improve our understanding of the pathogenesis of glucose intolerance in viral hepatitis. Her objectives during this award are to expand her research and mentoring program in multidisciplinary clinical and translational research in viral hepatitis, thereby increasing the pool of new investigators who ultimately become successful independent investigators. Dr. Khalili is an established investigator with significant mentoring experience who is committed to patient- oriented research, as evidenced by her ability to conduct high-quality research and her research leadership roles. Her multidisciplinary clinical and translational research program supported by ongoing extramural funding will serve as the platform for providing mentorship for junior investigators. She will capitalize on the rich academic environment of UCSF and its clinical research training resources, including K30 and K12 career development programs and the Clinical and Translational Sciences Institute to train her mentees to enable them to compete successfully for mentored career development awards in patient-oriented research and their transition to independence as clinical investigators. The pathophysiology, treatment, and prevention of both hepatitis C infection - the most common cause of liver disease in United States - and diabetes have been identified by the National Institutes of Health as high- priority areas of health research. Dr. Khalili's research goals are t continue to conduct clinical investigation in viral hepatitis and its complications that will provie insight into the relationship between hepatitis C and insulin action as well as host and viral interactions in disease pathogenesis. This research plan will provide mentoring and research training opportunities for new and junior clinical investigators in predictive modeling, in complex disease interactions, and in performing state-of-the-art physiologic measurements of insulin resistance and insulin secretion. In addition, the resources from her ongoing research activities will support mentees in performing patient-oriented research in viral hepatitis. The protected time afforded by this award will allow her to maintain her productivity and to achieve her mentorship and research goals.

简介（由申请人提供）：Mandana Khalili博士是加州大学旧金山分校（UCSF）的医学副教授。她的长期职业目标是指导早期临床研究人员致力于以患者为导向的研究，并成为努力提高我们对病毒性肝炎中葡萄糖耐受不良发病机制理解的领导者。她此次获奖的目的是扩大她在病毒性肝炎多学科临床和转化研究方面的研究和指导计划，从而增加最终成为成功独立研究者的新研究者的数量。哈利利博士是一位有丰富指导经验的资深调查员