Mentoring Multidisciplinary Patient-Oriented Research in Viral Hepatitis

指导病毒性肝炎的多学科、以患者为导向的研究

• 批准号: 8495606
• 负责人: Mandana Khalili
• 金额: $ 18.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8495606
• 关键词: Affect; Age; Alcohol consumption; Alcohols; American; Antiviral Therapy; Area; Attenuated; Award; California; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Commit; Complex; Data; Diabetes Mellitus; Diabetes prevention; Disease; Environment; Environmental Risk Factor; Extrahepatic; Extramural Activities; Family history of; Functional disorder; Funding; General Population; Glucose Intolerance; Goals; Health; Hepatitis C; Hepatitis C virus; Impairment; Incidence; Individual; Infection; Institutes; Insulin; Insulin Resistance; Insulin Signaling Pathway; Integration Host Factors; Interdisciplinary Study; K-Series Research Career Programs; Knowledge; Latino; Leadership; Liver diseases; Measurement; Measures; Mediating; Medicine; Mentors; Mentorship; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Pathogenesis; Patients; Peripheral; Persons; Physiological; Population; Populations at Risk; Prevention; Preventive Intervention; Productivity; Public Health; Recruitment Activity; Research; Research Activity; Research Personnel; Research Training; Resources; Risk; Risk Factors; Role; SECTM1 gene; San Francisco; Shapes; Staging; Time; Training; Training Support; Translational Research; United States; United States National Institutes of Health; Universities; Viral; Viral hepatitis; alcohol effect; base; career; career development; chronic liver disease; diabetes risk; drinking; experience; glucose metabolism; glucose uptake; improved; insight; insulin secretion; insulin sensitivity; liver transplantation; multidisciplinary; non-diabetic; patient oriented; patient oriented research; predictive modeling; professor; programs; public health relevance; response

DESCRIPTION (provided by applicant): Dr. Mandana Khalili is an Associate Professor of Medicine at the University of California, San Francisco (UCSF). Her long-term career objectives are to mentor early clinical investigators committed to patient-oriented research and to become a leader in efforts to improve our understanding of the pathogenesis of glucose intolerance in viral hepatitis. Her objectives during this award are to expand her research and mentoring program in multidisciplinary clinical and translational research in viral hepatitis, thereby increasing the pool of new investigators who ultimately become successful independent investigators. Dr. Khalili is an established investigator with significant mentoring experience who is committed to patient- oriented research, as evidenced by her ability to conduct high-quality research and her research leadership roles. Her multidisciplinary clinical and translational research program supported by ongoing extramural funding will serve as the platform for providing mentorship for junior investigators. She will capitalize on the rich academic environment of UCSF and its clinical research training resources, including K30 and K12 career development programs and the Clinical and Translational Sciences Institute to train her mentees to enable them to compete successfully for mentored career development awards in patient-oriented research and their transition to independence as clinical investigators. The pathophysiology, treatment, and prevention of both hepatitis C infection - the most common cause of liver disease in United States - and diabetes have been identified by the National Institutes of Health as high- priority areas of health research. Dr. Khalili's research goals are t continue to conduct clinical investigation in viral hepatitis and its complications that will provie insight into the relationship between hepatitis C and insulin action as well as host and viral interactions in disease pathogenesis. This research plan will provide mentoring and research training opportunities for new and junior clinical investigators in predictive modeling, in complex disease interactions, and in performing state-of-the-art physiologic measurements of insulin resistance and insulin secretion. In addition, the resources from her ongoing research activities will support mentees in performing patient-oriented research in viral hepatitis. The protected time afforded by this award will allow her to maintain her productivity and to achieve her mentorship and research goals.

描述(由申请人提供)：曼达纳·哈利利博士是加州大学旧金山分校(UCSF)医学副教授。她的长期职业目标是指导致力于以患者为中心的研究的早期临床研究人员，并成为努力提高我们对病毒性肝炎中葡萄糖耐受性发病机制的理解的领导者。她在此次获奖期间的目标是扩大她在病毒性肝炎的多学科临床和转化性研究方面的研究和指导计划，从而增加最终成为成功的独立研究人员的新调查员队伍。哈利利博士是一位有丰富指导经验的知名研究员 致力于以患者为导向的研究，她进行高质量研究的能力和她的研究领导作用证明了这一点。她的多学科临床和转化性研究计划由正在进行的外部资金支持，将作为为初级研究人员提供指导的平台。她将利用加州大学旧金山分校丰富的学术环境及其临床研究培训资源，包括K30和K12职业发展计划以及临床和翻译科学研究所，培训她的学员，使他们能够在以患者为导向的研究和向临床研究人员的独立过渡中成功竞争导师职业发展奖。丙型肝炎感染(美国最常见的肝病原因)和糖尿病的病理生理学、治疗和预防已被美国国立卫生研究院确定为卫生研究的高度优先领域。Khalili博士的研究目标是继续对病毒性肝炎及其并发症进行临床研究，以深入了解丙型肝炎与胰岛素作用的关系，以及疾病发病机制中宿主和病毒的相互作用。这项研究计划将为新的和初级的临床研究人员提供预测建模的指导和研究培训机会，在复杂的 疾病相互作用，以及对胰岛素抵抗和胰岛素分泌进行最先进的生理测量。此外，来自她正在进行的研究活动的资源将支持受训者进行以患者为导向的病毒性肝炎研究。这一奖项所提供的受保护的时间将使她能够保持她的生产力，并实现她的指导和研究目标。