Neuropathology Core

神经病理学核心

基本信息

批准号：
9922630
负责人：
CAROL A MILLER
金额：
$ 34.65万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9922630
关键词：
3-Dimensional Address Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease related dementia Amyloid beta-Protein Animal Disease Models Animal Model Apolipoprotein E Autopsy Award Basic Science Behavioral Biological Markers Biological Models Blood Blood - brain barrier anatomy Blood Vessels Blood capillaries Blood specimen Brain Cells Cerebrospinal Fluid Cerebrovascular Disorders Cerebrovascular system Clinical Clinical Research Collaborations Complex Consent Data Databases Dementia Diagnosis Diagnostic Disease Disease model Education Electrical Stimulation of the Brain Ethnic Origin Etiology Evaluation Extravasation Frontotemporal Dementia Genetic Diseases Genetic Research Genetic study Genotype Goals Human Image Individual Injury Institutes Label Laboratories Lewy Bodies Light Link Methods Microscopic Molecular Molecular Genetics Neurobiology Neurologic Neurologist Pathogenesis Pathology Patients Pilot Projects Preparation Psychometrics Radiology Specialty Regenerative Medicine Research Research Personnel Resolution Resource Sharing Retina Risk Factors Rodent Model Role Sampling Structure System Tissue Donations Tissue Sample Tissue imaging Tissues Training Training and Education Translational Research accurate diagnosis base blood product brain research cerebrovascular data management design ethnic diversity genetic analysis genetic risk factor genomic data glymphatic system human tissue improved in vivo induced pluripotent stem cell molecular marker neuroimaging neuropathology neurovascular injury neurovascular unit novel novel strategies novel therapeutics outreach public education recruit regenerative relating to nervous system research study statistics symposium translational approach two-photon vascular risk factor

项目摘要

ABSTRACT: Core D Neuropathology Alzheimer's disease (AD) is a multifactorial and complex disease and includes the impact of the cerebrovascular system on the induction and progression of the dementia. Correlation of experimental findings in disease models with the changes in the human CNS can now be approached with cellular, molecular and genetically related molecular markers. System connectivity is now approached three-dimensionally using novel methods of cellular labeling of animal model or human tissues combined with imaging, as seen with CLARITY-based preparations viewed with two-photon or lightsheet imaging. In AIM 1 the Neuropathology Core serves these functions by providing at autopsy, CNS tissues for accurate diagnoses of AD and accompanying pathologies. AIM 2 provides individual and multiple investigators with diseased tissues, blood, blood products and CSF for research. Contribution to a common database in AIM 3 serves to correlate neurological, psychometric, neuroimaging and behavioral data with the neuropathological and molecular findings. It also coordinates contribution of tissues, blood and cerebrospinal fluid (CSF) to national initiatives that also define genomic data, such as ApoE and other risk factors, and biomarker information addressed in AIMS 4-6, that highlight those functional in the neurovascular unit and in the blood-brain-barrier, and the recently described “glymph” system. In AIM 7, training and education of neuropathologists, neurologists, and neuroscientists bring AD and related dementia further into focus by defining the potential translational approaches leading to novel therapies.

摘要：核心D神经病理学阿尔茨海默氏病（AD）是一种多因素且复杂的疾病，包括脑血管系统有关痴呆症的诱导和进展。相关性疾病模型中具有人类中枢神经系统变化的疾病模型的实验发现现在可以与细胞，分子和遗传相关的分子标记接近。系统现在，使用新颖的细胞标记方法在三维方面进行连通性动物模型或人类组织与成像结合，如基于清晰度的用两光子或灯表成像查看的制剂。在AIM 1中神经病理学核心通过在尸检时提供CNS组织，以准确诊断AD和 AIM 2为个人和多个调查员提供了解剖组织，血液，血液产物和CSF进行研究。对公共数据库的贡献 AIM 3用于将神经系统，心理测量，神经影像学和行为数据与神经病理学和分子发现。它还协调组织，血液的贡献和脑脊液（CSF）到也定义基因组数据的国家计划，例如APOE 以及其他危险因素以及目标4-6中涉及的生物标志物信息，这些信息强调了这些因素在神经血管单元和血脑屏障中的功能，最近描述的 “ GlyMPH”系统。在AIM 7中，神经病理学家，神经科医生和教育神经科学家通过定义潜力将AD和相关痴呆症进一步焦点转化方法导致新疗法。