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中文摘要
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核心A:行政核心 项目摘要/摘要 UCI ADRC行政核心提供行政支持和监督,具有很强的创新性 领导力,并协调与中心核心(临床、数据)的集成和中心 管理和统计,神经病理学,外展招聘和参与,诱导多能性 干细胞、生物标记物、唐氏综合症和90+),以及研究教育部分(REC)。《博大》 UCI ADRC的主题是“识别、量化和验证影响整个地区AD风险的因素 寿命。“除了关注中心的行政细节外,行政核心集中在五个方面 对我们的整体活力和生产力有重大影响的广泛活动:促进以中心为中心, 聘用和招聘新教员,促进AD研究,确保我们的研究人员拥有最先进的 设施,积极投身慈善事业。UCI ADRC管理核心支持以下广泛目标 我们的ADRC在对痴呆症的机制进行基础和有针对性的临床研究时,并在 我们在神经生物学方面对年龄相关的认知衰退和阿尔茨海默病的丰富研究历史。保持高度的 功能和高效的中心使行政核心能够促进AD研究的创新,促进 协作(包括核心到核心的互动和在ADRC网络内),并支持教育 下一代科学家、临床医生和我们社区的成员。行政核心 促进中心协作、创新和教育的总体目标,并促进国家 阿尔茨海默氏症项目法(NAPA)研究实施里程碑和目标。行政核心 利用机会发展我们的中心,并在招聘10名新教师到 在过去的四年里,ADRC,其中许多人是各自学科的领导者,并已成为 中心的核心之一。行政核心的领导深信不疑,致力于 大量的时间来确保我们的中心是成功的和尖端的。积极参与,积极参与 在过去的几年里,行政核心领导层通过以下方式帮助我们的中心实现了转型 促进创新和新想法,例如建立我们的新型特殊人口核心(Down 综合征核心和90+核心),我们新的参与者招募登记(同意联系,C2C),以及我们的 诱导多能干细胞(IPSC)核心。
英文摘要
Core A: Administrative Core Project Summary/Abstract The UCI ADRC Administrative Core provides administrative support and oversight, strong innovative leadership, and orchestrates the integration and centeredness with the cores of the Center (Clinical, Data Management and Statistical, Neuropathology, Outreach Recruitment and Engagement, Induced Pluripotent Stem Cell, Biomarker, Down Syndrome and 90+), and the Research Education Component (REC). The broad theme of the UCI ADRC is “to identify, quantify, and validate factors that influence the risk of AD across the lifespan.” Beyond attending to the administrative details of the Center, the Administrative Core focuses on five broad activities that have a significant impact on our overall vitality and productivity: promote centeredness, engage and recruit new faculty, facilitate AD research, ensure that our researchers have state-of-the-art facilities, and actively engage in philanthropy. The UCI ADRC Administrative Core supports the broad goals of our ADRC as we perform basic and targeted clinical studies into the mechanisms of dementia and builds on our rich history in neurobiology research into age-related cognitive decline and AD. Maintaining a highly functioning and efficient Center enables the Administrative Core to foster innovation in AD research, facilitate collaborations (including core-to-core interactions and within the ADRC network), and support the education of the next generation of scientists, clinicians, and members of our community. The Administrative Core facilitates the Center's overall goals of collaboration, innovation, and education, and promotes the National Alzheimer's Project Act (NAPA) research implementation milestones and goals. The Administrative Core capitalizes on opportunities to grow our Center and played a major role in recruiting ten new faculty to the ADRC over the past four years, many of whom are leaders in their subdiscipline and have become leaders of one of the Cores in the Center. The leaders of the Administrative Core are deeply committed and devote a significant amount of time to ensure that our Center is successful and cutting-edge. The active engagement of the Administrative Core leadership has helped to transform our Center over the past several years by promoting innovation and new ideas, such as the establishment of our novel Special Populations Cores (Down Syndrome Core and 90+ Core), our new participant recruitment registry (Consent-to-Contact, C2C), and our induced pluripotent stem cell (iPSC) Core.
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Deciphering the role of interleukin-18 as a driver of tau pathology in Alzheimer's disease
  • 批准号:
    10463741
  • 项目类别:
  • 资助金额:
    $39.25万
  • 财政年份:
    2021
  • 负责人:
    FRANK M LAFERLA
  • 依托单位:
Deciphering the role of interleukin-18 as a driver of tau pathology in Alzheimer's disease
  • 批准号:
    10636861
  • 项目类别:
  • 资助金额:
    $39.25万
  • 财政年份:
    2021
  • 负责人:
    FRANK M LAFERLA
  • 依托单位:
Deciphering the role of interleukin-18 as a driver of tau pathology in Alzheimer's disease
  • 批准号:
    10280235
  • 项目类别:
  • 资助金额:
    $39.25万
  • 财政年份:
    2021
  • 负责人:
    FRANK M LAFERLA
  • 依托单位:
The Alzheimer's Disease Research Center at the University of California, Irvine
  • 批准号:
    10582616
  • 项目类别:
  • 资助金额:
    $288.48万
  • 财政年份:
    2020
  • 负责人:
    FRANK M LAFERLA
  • 依托单位:
海外基金