Clinical Core

摘要 华盛顿大学阿尔茨海默病研究中心(ADRC)的临床核心是一项有价值的 构成该中心支持有意义和创新的ADRD研究的总体目标。最新进展 人类遗传学、病理学和成像技术揭示了ADRD的生物多样性。这个 UW临床核心的目标是在其纵向队列中捕获ADRD异质性的频谱，以支持 参与者的多模式研究。灵敏的表型鉴定对尸检的解释至关重要 病理学和死前影像的异质性。为此，我们扩展了我们的神经心理学 评估以确定相对脆弱和有弹性的认知域。承认有效的ADRD 面向所有人的疗法需要在代表性不足的群体中改进ADRD的研究，我们制定了一项战略 与我们的外联、招聘和参与核心合作，以增强我们ADRC的多样性。在过去5年中 多年来，UW ADRC与以Dr. 德拉·布赫瓦尔德。在这个循环中，我们通过开发纵向的共识算法来继续这一努力 布赫瓦尔德博士的团队收集了认知和临床数据。此外，我们还与UW ADRC的 本地研究和资源核心(NRRC)，以社区参与式数据为基础 AI/AN人群研究方法与社区敏感统一ADRD临床研究 评估。推动临床核心组成的基本原理是a)反映华盛顿大学ADRC的科学主题 异质性和复原力：b)回应红十字与红新月会研究界的科学需要；c) 增加临床核心的种族、社会经济和教育程度的多样性。在这个循环中， 临床核心将1)临床特征和纵向跟踪正常衰老，先兆和 代表疾病的临床、解剖和风险异质性的症状性ADRD，并促进其 纳入研究2)促进将未充分代表的群体纳入ADRD研究和合作 在人工智能/人工智能研究中建立诊断算法3)使用现代心理测量学方法共同校准 UDS、登记前临床测试和外部研究的认知分数，以整合登记前 认知数据并促进跨和4)获得纵向脑脊液、血液和皮肤的互操作性 来自具有良好特征的研究参与者队列的生物标本，呈现正常和 病理性衰老、前驱痴呆和ADRD。

Abstract The University of Washington (UW) Alzheimer Disease Research Center (ADRC) Clinical Core is a valuable component the center's overall aim of supporting meaningful and innovative ADRD research. Advances in human genetics, pathological and imaging technologies have revealed the biological diversity of ADRD. The UW Clinical Core aims to capture this spectrum of ADRD heterogeneity in its longitudinal cohort to support multi-modal study of participants. Sensitive phenotyping is critical to the interpretation of post-mortem pathology and ante-mortem imaging heterogeneity. To that end, we have expanded our neuropsychological evaluation to identify relative vulnerable and resilient cognitive domains. Acknowledging that effective ADRD therapies for all requires improving study of ADRD in under-represented groups, we have developed a strategy with our Outreach Recruitment and Engagement Core to enhance the diversity of our ADRC. Over the last 5 years the UW ADRC has built a strong collaborative relationship with the Partners for Native Health, led by Dr. Dedra Buchwald. In this cycle we continue this effort through developing consensus algorithms for longitudinal cognitive and clinical data collected by Dr. Buchwald's team. Additionally, we work with the UW ADRC's Native Research and Resource Core (NRRC) to build upon data derived from community based participatory research approaches in the AI/AN population and develop community sensitive uniform ADRD clinical evaluations. The rationale driving the Clinical Core composition is to a) reflect the UW ADRC scientific theme of heterogeneity and resilience b) respond to the scientific needs of the ADRC research community and c) increase the racial, socioeconomic and educational attainment diversity of the Clinical Core. In this cycle, the Clinical Core will 1) Characterize clinically and follow longitudinally persons with normal aging, prodromal and symptomatic ADRD representing the clinical, anatomic and risk heterogeneity of disease, and promote their inclusion into research 2) Promote the inclusion of underrepresented groups in ADRD research and collaborate to establish diagnostic algorithms in AI/AN studies 3) Use modern psychometric approaches to co-calibrate cognitive scores across UDS, pre-enrollment clinical tests, and external studies to integrate pre-enrollment cognitive data and facilitate interoperability across and 4) obtain longitudinal CSF, blood and skin biospecimens from a well-characterized cohort of research participants presenting with normal and pathological aging, prodromal dementia and ADRD.