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Towards Multisystem-Brain Successful Aging in Schizophrenia Spectrum

精神分裂症谱系迈向多系统大脑成功衰老

基本信息

批准号：
9922360
负责人：
L Elliot Elliot Hong
金额：
$ 72.55万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9922360
关键词：
Accounting Acute Address Age Age-Years Aging Automobile Driving Base of the Brain Biochemical Brain Brain Diseases Brain imaging Cardiovascular Diseases Cardiovascular system Cessation of life Clinical Data Analyses Diffusion Magnetic Resonance Imaging Disease Elderly General Population Glucocorticoids Goals Health Hippocampus (Brain)Hormones Hydrocortisone Hypothalamic structure Impairment Inflammatory Inflammatory Response Intercept Investigation Lead Longevity Longitudinal cohort Measures Mediating Mediation Mediator of activation protein Medical Mental disorders Metabolic Marker Modeling Morbidity - disease rate Onset of illness Outcome Pathway interactions Patients Peripheral Pharmaceutical Preparations Prevention Psychiatric therapeutic procedure Psychological Stress Psychotic Disorders Research Research Proposals Rest Risk Risk Factors Schizophrenia Smoking Socioeconomic Status Span 20 Stress Structure Symptoms System Testing Trauma age effect age related allostasis allostatic load biological adaptation to stress brain abnormalities brain circuitry clinical development clinically actionable cohort comorbidity connectome design developmental disease functional outcomes gamma-Aminobutyric Acid imaging study indexing inflammatory marker longitudinal analysis longitudinal design mind body interaction model design mortality multimodality neurochemistry primary outcome psychological stressor response sex white matter

项目摘要

Project Summary Brain imaging research has revealed accelerated age-related white matter, neurochemical and perhaps cortical changes in patients with schizophrenia spectrum disorders. However, imaging studies are typically brain-focused without system-level investigations on the risk factors. Patients with schizophrenia spectrum disorders also have a much shorter lifespan and high morbidity and mortality. However, medical comorbidity studies typically do not include brain-based investigations. It remains unclear why schizophrenia spectrum disorders have high age-related medical burden. Cumulative stress effects are predictive of successful aging in healthy older adults. In patients with schizophrenia spectrum disorders, cumulative stress may disrupt brain structure and function, and/or impaired brain structure and function may distort normal responses to stress leading to increased cumulative stress effects. The proposal research will study cumulative stress and brain imaging age-progression in an age span of 45 years, using a combined longitudinal and age-cohort cross- sectional design. The study proposes to track the progression of stress-related risk factors in the periphery, and the age-related changes in the brain, and to determine whether they will independently or interactively contribute to age-related medical health and functional outcomes in patients with schizophrenia spectrum disorders. These findings may guide the development of clinically actionable strategies to intercept abnormal aging and promote successful aging in patients with this devastating illness.

项目摘要大脑成像研究显示，与年龄相关的白色物质、神经化学物质，精神分裂症谱系障碍患者的皮质改变。然而，成像研究通常没有对风险因素进行系统层面的调查。精神分裂症谱系患者疾病的寿命也短得多，发病率和死亡率高。然而，医疗并发症研究通常不包括基于大脑的调查。目前尚不清楚为什么精神分裂症疾病具有与年龄相关的高医疗负担。累积的压力效应是成功老化的预测，健康的老年人。在精神分裂症谱系障碍患者中，累积的压力可能会破坏大脑结构和功能，和/或受损的大脑结构和功能可能会扭曲对压力的正常反应导致增加的累积应力效应。这项研究将研究累积的压力和大脑在45岁的年龄跨度成像年龄进展，使用纵向和年龄队列交叉组合，分段设计该研究建议跟踪与压力相关的风险因素在外围的进展，以及大脑中与年龄相关的变化，并确定它们是否会独立或相互作用，有助于精神分裂症患者年龄相关的医疗健康和功能结局紊乱这些发现可以指导临床上可行的策略的发展，以拦截异常的衰老并促进患有这种毁灭性疾病的患者成功衰老。