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Towards Multisystem-Brain Successful Aging in Schizophrenia Spectrum

精神分裂症谱系迈向多系统大脑成功衰老

基本信息

批准号：
10392882
负责人：
L Elliot Elliot Hong
金额：
--
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-08-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10392882
关键词：
Accounting Acute Address Age Age-Years Aging Automobile Driving Base of the Brain Biochemical Brain Brain Diseases Brain imaging Cardiovascular Diseases Cardiovascular system Cessation of life Clinical Data Analyses Diffusion Magnetic Resonance Imaging Disease Elderly General Population Glucocorticoids Goals Health Hippocampus (Brain)Hormones Hydrocortisone Hypothalamic structure Impairment Inflammatory Inflammatory Response Intercept Investigation Lead Longevity Longitudinal cohort Measures Mediating Mediation Mediator of activation protein Medical Mental disorders Metabolic Marker Modeling Morbidity - disease rate Onset of illness Outcome Pathway interactions Patients Peripheral Pharmaceutical Preparations Prevention Psychiatric therapeutic procedure Psychological Stress Research Research Proposals Rest Risk Risk Factors Schizophrenia Smoking Socioeconomic Status Span 20 Stress Structure Symptoms System Testing Trauma age effect age related allostasis allostatic load biological adaptation to stress brain abnormalities brain circuitry brain dysfunction clinical development clinically actionable cohort comorbidity connectome design developmental disease functional outcomes gamma-Aminobutyric Acid imaging study indexing inflammatory marker longitudinal analysis longitudinal design mind body interaction model design mortality multimodality neurochemistry primary outcome psychological stressor psychosis risk response schizophrenia-spectrum disorder sex white matter

项目摘要

Project Summary Brain imaging research has revealed accelerated age-related white matter, neurochemical and perhaps cortical changes in patients with schizophrenia spectrum disorders. However, imaging studies are typically brain-focused without system-level investigations on the risk factors. Patients with schizophrenia spectrum disorders also have a much shorter lifespan and high morbidity and mortality. However, medical comorbidity studies typically do not include brain-based investigations. It remains unclear why schizophrenia spectrum disorders have high age-related medical burden. Cumulative stress effects are predictive of successful aging in healthy older adults. In patients with schizophrenia spectrum disorders, cumulative stress may disrupt brain structure and function, and/or impaired brain structure and function may distort normal responses to stress leading to increased cumulative stress effects. The proposal research will study cumulative stress and brain imaging age-progression in an age span of 45 years, using a combined longitudinal and age-cohort cross- sectional design. The study proposes to track the progression of stress-related risk factors in the periphery, and the age-related changes in the brain, and to determine whether they will independently or interactively contribute to age-related medical health and functional outcomes in patients with schizophrenia spectrum disorders. These findings may guide the development of clinically actionable strategies to intercept abnormal aging and promote successful aging in patients with this devastating illness.

项目总结