Towards Multisystem-Brain Successful Aging in Schizophrenia Spectrum

精神分裂症谱系迈向多系统大脑成功衰老

• 批准号: 10392882
• 负责人: L Elliot Elliot Hong
• 金额: --
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-08-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392882
• 关键词: Accounting; Acute; Address; Age; Age-Years; Aging; Automobile Driving; Base of the Brain; Biochemical; Brain; Brain Diseases; Brain imaging; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Clinical; Data Analyses; Diffusion Magnetic Resonance Imaging; Disease; Elderly; General Population; Glucocorticoids; Goals; Health; Hippocampus (Brain); Hormones; Hydrocortisone; Hypothalamic structure; Impairment; Inflammatory; Inflammatory Response; Intercept; Investigation; Lead; Longevity; Longitudinal cohort; Measures; Mediating; Mediation; Mediator of activation protein; Medical; Mental disorders; Metabolic Marker; Modeling; Morbidity - disease rate; Onset of illness; Outcome; Pathway interactions; Patients; Peripheral; Pharmaceutical Preparations; Prevention; Psychiatric therapeutic procedure; Psychological Stress; Research; Research Proposals; Rest; Risk; Risk Factors; Schizophrenia; Smoking; Socioeconomic Status; Span 20; Stress; Structure; Symptoms; System; Testing; Trauma; age effect; age related; allostasis; allostatic load; biological adaptation to stress; brain abnormalities; brain circuitry; brain dysfunction; clinical development; clinically actionable; cohort; comorbidity; connectome; design; developmental disease; functional outcomes; gamma-Aminobutyric Acid; imaging study; indexing; inflammatory marker; longitudinal analysis; longitudinal design; mind body interaction; model design; mortality; multimodality; neurochemistry; primary outcome; psychological stressor; psychosis risk; response; schizophrenia-spectrum disorder; sex; white matter

Project Summary Brain imaging research has revealed accelerated age-related white matter, neurochemical and perhaps cortical changes in patients with schizophrenia spectrum disorders. However, imaging studies are typically brain-focused without system-level investigations on the risk factors. Patients with schizophrenia spectrum disorders also have a much shorter lifespan and high morbidity and mortality. However, medical comorbidity studies typically do not include brain-based investigations. It remains unclear why schizophrenia spectrum disorders have high age-related medical burden. Cumulative stress effects are predictive of successful aging in healthy older adults. In patients with schizophrenia spectrum disorders, cumulative stress may disrupt brain structure and function, and/or impaired brain structure and function may distort normal responses to stress leading to increased cumulative stress effects. The proposal research will study cumulative stress and brain imaging age-progression in an age span of 45 years, using a combined longitudinal and age-cohort cross- sectional design. The study proposes to track the progression of stress-related risk factors in the periphery, and the age-related changes in the brain, and to determine whether they will independently or interactively contribute to age-related medical health and functional outcomes in patients with schizophrenia spectrum disorders. These findings may guide the development of clinically actionable strategies to intercept abnormal aging and promote successful aging in patients with this devastating illness.

项目概要 脑成像研究揭示了与年龄相关的白质、神经化学物质和可能的加速 精神分裂症谱系障碍患者的皮质变化。然而，影像学研究通常 以大脑为中心，没有对风险因素进行系统级调查。精神分裂症谱系患者 疾病的寿命也短得多，发病率和死亡率也高。然而，医疗合并症 研究通常不包括基于大脑的调查。目前尚不清楚为什么精神分裂症谱系 疾病具有与年龄相关的高医疗负担。累积压力效应可预测成功衰老 健康的老年人。在患有精神分裂症谱系障碍的患者中，累积的压力可能会扰乱大脑 结构和功能，和/或大脑结构和功能受损可能会扭曲对压力的正常反应 导致累积压力效应增加。该提案研究将研究累积压力和大脑 使用纵向和年龄队列交叉相结合的方法，对 45 岁的年龄跨度内的年龄进展进行成像 剖面设计。该研究建议追踪周边地区与压力相关的危险因素的进展， 以及大脑中与年龄相关的变化，并确定它们是独立的还是交互的 有助于精神分裂症谱系患者与年龄相关的医疗健康和功能结果 失调。这些发现可能会指导制定临床上可行的策略来拦截异常 衰老并促进患有这种毁灭性疾病的患者成功衰老。