Long-term physiological and behavioral outcomes, epigenetic profiles and multigenerational phenotypes in a mouse ART model

小鼠 ART 模型中的长期生理和行为结果、表观遗传特征和多代表型

基本信息

  • 批准号:
    9921459
  • 负责人:
  • 金额:
    $ 33.41万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-08-15 至 2022-04-30
  • 项目状态:
    已结题

项目摘要

Abstract Infertile couples are increasingly turning to Assisted Reproductive Technologies (ART) to treat their infertility. Of growing concern is that ART-conceived children are at increased risk for specific loss-of-imprinting disorders, congenital malformations, growth restriction, preeclampsia as well as postnatal cardiac and metabolic disorders. Given the difficulty of conducting studies using human embryos, a mouse model system, which anticipated some risks associated with ART, will be used to assess the effects of ART on placental morphology, imprinted gene regulation, growth, metabolic, cardiac and behavioral phenotypes of the offspring, and gene expression and chromatin structure genome-wide. Specific Aim 1 will assess the phenotypes, including growth, behavior metabolism and cardiovascular function, of ART-offspring in comparison to naturally-conceived controls. We will also interrogate imprinted gene regulation and gene expression, DNA methylation and chromatin structure using gene-specific and high throughput analyses. Moreover, the design of this aim will enable us to isolate, phenotype and match placenta to offspring to determine whether the placental phenotype can accurately predict health of in vitro fertilization (IVF)-derived offspring. Because we have previously reported a low frequency of epigenetic errors in multiple tissues of IVF-conceived offspring, we hypothesize that the germline cells also harbor epigenetic mutations. In Specific Aim 2, we will test this hypothesis by determining whether aberrant phenotypes observed in IVF offspring are transmitted to subsequent generations and, if so, assess the mechanism of this transmission. The result from these experiments will provide a trove of information regarding the linkage between epigenetic changes and health of offspring conceived by ART and whether placental phenotyping can predict offspring health. Our findings may also suggest experimental modifications to ART procedures that can improve offspring outcomes. !
摘要

项目成果

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MARISA S. BARTOLOMEI其他文献

MARISA S. BARTOLOMEI的其他文献

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{{ truncateString('MARISA S. BARTOLOMEI', 18)}}的其他基金

Role of TET1 in germ cell reprogramming and development
TET1 在生殖细胞重编程和发育中的作用
  • 批准号:
    10467364
  • 财政年份:
    2022
  • 资助金额:
    $ 33.41万
  • 项目类别:
Role of TET1 in germ cell reprogramming and development
TET1 在生殖细胞重编程和发育中的作用
  • 批准号:
    10689734
  • 财政年份:
    2022
  • 资助金额:
    $ 33.41万
  • 项目类别:
Tri-Institutional Symposium on Reproductive Biology & Infertility (Tri-Repro)
生殖生物学三机构研讨会
  • 批准号:
    10171876
  • 财政年份:
    2020
  • 资助金额:
    $ 33.41万
  • 项目类别:
Tri-Institutional Symposium on Reproductive Biology & Infertility (Tri-Repro)
生殖生物学三机构研讨会
  • 批准号:
    10405090
  • 财政年份:
    2020
  • 资助金额:
    $ 33.41万
  • 项目类别:
Tri-Institutional Symposium on Reproductive Biology & Infertility (Tri-Repro)
生殖生物学三机构研讨会
  • 批准号:
    10626897
  • 财政年份:
    2020
  • 资助金额:
    $ 33.41万
  • 项目类别:
Preconception phthalate exposure and offspring outcomes
孕前邻苯二甲酸盐暴露和后代结果
  • 批准号:
    9759938
  • 财政年份:
    2017
  • 资助金额:
    $ 33.41万
  • 项目类别:
Preconception phthalate exposure and offspring outcomes
孕前邻苯二甲酸盐暴露和后代结果
  • 批准号:
    9362020
  • 财政年份:
    2017
  • 资助金额:
    $ 33.41万
  • 项目类别:
Long-term physiological and behavioral outcomes, epigenetic profiles and multigenerational phenotypes in a mouse ART model
小鼠 ART 模型中的长期生理和行为结果、表观遗传特征和多代表型
  • 批准号:
    10152633
  • 财政年份:
    2017
  • 资助金额:
    $ 33.41万
  • 项目类别:
Preconception phthalate exposure and offspring outcomes
孕前邻苯二甲酸盐暴露和后代结果
  • 批准号:
    10246409
  • 财政年份:
    2017
  • 资助金额:
    $ 33.41万
  • 项目类别:
Sequences controlling H19 Gene Imprinting
控制 H19 基因印记的序列
  • 批准号:
    9534673
  • 财政年份:
    2016
  • 资助金额:
    $ 33.41万
  • 项目类别:

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Angiogenic factors, abnormal placentation and adverse pregnancy outcomes
血管生成因素、异常胎盘和不良妊娠结局
  • 批准号:
    8927757
  • 财政年份:
    2014
  • 资助金额:
    $ 33.41万
  • 项目类别:
Angiogenic factors, abnormal placentation and adverse pregnancy outcomes
血管生成因素、异常胎盘和不良妊娠结局
  • 批准号:
    8626424
  • 财政年份:
    2012
  • 资助金额:
    $ 33.41万
  • 项目类别:
Angiogenic factors, abnormal placentation and adverse pregnancy outcomes
血管生成因素、异常胎盘和不良妊娠结局
  • 批准号:
    8441511
  • 财政年份:
    2012
  • 资助金额:
    $ 33.41万
  • 项目类别:
Angiogenic factors, abnormal placentation and adverse pregnancy outcomes
血管生成因素、异常胎盘和不良妊娠结局
  • 批准号:
    8240765
  • 财政年份:
    2012
  • 资助金额:
    $ 33.41万
  • 项目类别:
Analysis of the effect of oxidative stress on abnormal placentation
氧化应激对胎盘异常的影响分析
  • 批准号:
    23890101
  • 财政年份:
    2011
  • 资助金额:
    $ 33.41万
  • 项目类别:
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