Analysis of the effect of oxidative stress on abnormal placentation

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We assesed the expression of trophoblast invasion related molecules in placenta previa, especially accreta. We immunohistochemically assessed the expressions of thioredoxin (TRX), TLR3, TLR4, CD56, CD68, VEGF in the placenta of control, PIH, placenta previa and placenta accreta, and placental bed of control and placenta accreta. TRX expression is slightly higher in PIH placenta, especially chorion and decidua. In placenta previa and accreta, TRX expression is hardly seen in all the area of placenta.There are little differences of expression in other molecules. TRX expression decreased in placenta previa and accreta. It may indicate that oxidative stress decreases andtherefore preeclampsia frequency is reduced in placenta previa.