Matching supply and demand: how does metabolism fine-tune signal transduction?

匹配供需：新陈代谢如何微调信号转导？

• 批准号: nhmrc : 1072440
• 负责人: Dr James Krycer
• 金额: $ 21.1万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/matching-supply-demand-signal-transduction/455510
• 关键词: Matching; supply; demand; how; does

Insulin controls nutrient traffic and disrupting its actions are linked to many diseases: type 2 diabetes, cancer, heart disease. Here, I will test a novel hypothesis that our cells’ metabolic rate, defined by the balance between nutrient supply and energy expenditure, controls how cells respond to insulin. These metabolic regulatory nodes would play a major determinant of many essential functions linked to human health, and thus provide novel therapeutic targets for numerous diseases.

胰岛素控制着营养物质的运输，扰乱它的作用与许多疾病有关：2型糖尿病、癌症、心脏病。在这里，我将测试一个新的假设，即我们的细胞的代谢率，由营养供应和能量支出之间的平衡定义，控制着细胞对胰岛素的反应。这些代谢调节节点将扮演许多与人类健康相关的基本功能的主要决定因素，从而为许多疾病提供新的治疗靶点。