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Dopaminergic modulation in auditory decision-making

听觉决策中的多巴胺能调节

基本信息

批准号：
9923440
负责人：
Allen Chen
金额：
$ 3.62万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-09 至 2024-04-08
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9923440
关键词：
Address Affect Animals Auditory Auditory Perception Auditory Perceptual Disorders Auditory area Behavior Behavioral Brain Diseases Brain imaging Calcium Cells Central Auditory Processing Disorder Cognition Corpus striatum structure Cues Data Decision Making Discrimination Disease Dopamine Dopamine Antagonists Dopamine Receptor Dorsal Elements Environment Etiology Frequencies Functional disorder Goals Image Impairment Knowledge Label Lead Learning Life Literature Maps Mediating Monitor Mus Neostriatum Neuromodulator Neurons Neurotransmitters Parkinson Disease Pattern Perception Performance Pharmacology Phase Play Population Process Psychological reinforcement Psychometrics Reaction Time Rodent Role Schizophrenia Sensory Signal Transduction Substantia nigra structure Task Performances Technical Expertise Testing TimeLine Viral auditory processing auditory stimulus autism spectrum disorder base discrete time dopaminergic neuron in vivo innovation insight neural correlate neuromechanism neuropsychiatric disorder neuroregulation optogenetics pars compacta sound

项目摘要

PROJECT SUMMARY I propose to study the role of dopamine signaling within the neostriatum in the context of auditory-based decision- making. Decision-making based on sensory perception is an integral part of everyday life and a cornerstone of ones ability to respond to the environment with appropriate actions. This pivotal process is dysfunctional in neuropsychiatric disorders such as Parkinson’s disease and schizophrenia. Studies demonstrate that the neostriatum is a neural correlate for perception-based decision-making and that striatal neurotransmitter imbalances can disrupt such behaviors. Our lab studies a caudal portion of the dorsal striatum—referred to as the “auditory striatum,” and we have shown that this striatal region is important for auditory cue-based decision- making and reinforcement learning. While it has been shown that auditory corticostriatal projections drive auditory decision-making in rodents, it is unclear how established striatal neuromodulators including dopamine influence these functions. Recent evidence indicates that neuromodulatory control and behavioral states play a critical role in a wide variety of auditory behaviors. My preliminary pharmacological and tract-tracing data indicate that dopamine, a key striatal neuromodulator, indeed plays a role in within the auditory striatum for auditory decision-making. These data and previous literature contribute to my central hypothesis, which is that dopaminergic signaling in the auditory striatum contributes to auditory decision-making by modulating striatal sound representation. To address this hypothesis and to hone in on dopamine’s role, I propose two aims. First, in Aim 1, I will monitor the activity of identified auditory striatum-projecting dopaminergic substantia nigra pars compacta neurons through in vivo Ca2+ imaging and map these dynamics with respect to specific epochs of the auditory decision-making task. Knowledge of how the activity of these dopamine neurons changes with respect to decision-making behavior will allow me to infer how dopaminergic mechanisms modulate choice accuracy. For instance, if DA activity corresponds to sound cue presentation, it may suggest that DA activity modulates sound representation in the auditory striatum. In Aim 2, I will evaluate the importance of dopaminergic modulation in the auditory task by optogenetically inhibiting dopaminergic projections during the same sets of defined epochs of the auditory decision-making task evaluated in Aim 1. This will demonstrate whether dopamine is necessary for mediating specific aspects of auditory decision-making, including sound cue representation. Overall, I will use circuit-specific labeling, microendoscopic monitoring, and optogenetics in mice to investigate the role of dopamine in auditory decision-making. Results from this study will advance understanding of how striatal dopamine contributes to auditory perceptual decision-making, which in turn could bring new etiological insights for auditory processing disorders and neuropsychiatric disease.

项目总结