Tumor Microenvironment Research Program

UWCCC肿瘤微环境（TM）计划摘要 联合负责人：Patricia Keely和大卫毕比 项目概要/摘要 肿瘤是由肿瘤细胞、基质细胞、可溶性因子和细胞外基质组成的复杂系统。 基质（ECM）;这些成分共同构成肿瘤微环境。虽然癌症研究 历史上专注于研究和治疗肿瘤细胞，现在很清楚， 肿瘤微环境是肿瘤进展的积极参与者。例如，生长因子分泌的 肿瘤细胞吸引免疫细胞进入肿瘤微环境;这些免疫细胞反过来提供细胞因子 以及其他刺激基质细胞沉积和ECM重塑的因素，其反馈影响 肿瘤细胞行为尽管肿瘤微环境在肿瘤的进展中无疑是重要的， 针对几种类型的癌症，针对微环境的治疗方法仍然很少，部分地， 因为这方面的知识还不够。因此，肿瘤微环境的使命 (TM)程序，以确定发生在肿瘤发生过程中的微环境变化，并分析如何 肿瘤细胞与微环境成分之间的相互作用影响肿瘤的形成、生长， 进展，最终转移。为了实现这些目标，TM计划促进合作 来自17个部门的32名成员-基础科学家，临床医生和生物工程师，他们专门从事 模拟体内环境的系统的开发和系统级的计算建模 行为。TM计划研究分为三个主题领域：1）细胞外基质，2）工程 方法，和3）免疫相互作用。项目成员获得了300万美元的直接费用， NCI资金和1060万美元的直接费用，在同行评审的癌症相关支持总额中， 在最后一次赠款期间出版了494篇出版物。在这些出版物中，13%是内部出版物， 24%是方案合作，24%是方案间合作。仅在2016年， 50%的出版物是与其他机构合作的。通过这些研究工作， TM计划正在确定新的生物标志物和治疗方法。

UWCCC Tumor Microenvironment (TM) Program Summary Co-Leaders: Patricia Keely and David Beebe PROJECT SUMMARY/ABSTRACT Tumors are complex systems composed of tumor cells, stromal cells, soluble factors, and the extracellular matrix (ECM); together, these components constitute the tumor microenvironment. While cancer research has focused historically on studying and treating the tumor cell, it is now clear that the other components of the tumor microenvironment are active participants in tumor progression. For example, growth factors secreted by tumor cells attract immune cells into the tumor microenvironment; these immune cells in turn provide cytokines and other factors that stimulate stromal cell deposition and remodeling of ECM, which feedback to influence tumor cell behavior. Although the tumor microenvironment is undoubtedly important in the progression of several types of cancer, therapeutic approaches targeted against the microenvironment remain rare, in part, because knowledge in this area is insufficient. Therefore, it is the mission of the Tumor Microenvironment (TM) Program to identify microenvironmental changes that occur during tumorigenesis and analyze how the interactions between the tumor cell and microenvironmental components affect tumor formation, growth, progression, and ultimately metastasis. To accomplish these goals, the TM program fosters collaborations between its 32 members from 17 departments - basic scientists, clinicians, and bioengineers who specialize in the development of systems that mimic the in vivo environment and computational modeling of systems-level behaviors. TM program research is organized into three thematic areas: 1) Extracellular Matrix, 2) Engineering Approaches, and 3) Immune Interactions. Program members were supported by $3.0 million direct costs in NCI-funding and $10.6 million direct costs in total peer-reviewed cancer-related support, and were highly productive with 494 publications during the course of the last grant. Of these publications, 13% were intra- programmatic collaborations and 24% were inter-programmatic collaborations. In the year 2016 alone, nearly 50% of publications were collaborative with other institutions. Through these research efforts, members of the TM program are identifying new biomarkers and therapeutic approaches.