Tumor Microenvironment Research Program

UWCCC肿瘤微环境(TM)计划摘要 联合领导人：帕特里夏·基利和大卫·毕比 项目摘要/摘要 肿瘤是由肿瘤细胞、间质细胞、可溶性因子和细胞外因子组成的复杂系统。 基质(ECM)；这些成分共同构成了肿瘤微环境。虽然癌症研究已经 历史上一直专注于研究和治疗肿瘤细胞，现在很明显， 肿瘤微环境是肿瘤进展的积极参与者。例如，由人分泌的生长因子 肿瘤细胞吸引免疫细胞进入肿瘤微环境；这些免疫细胞反过来提供细胞因子 以及其他刺激ECM间质细胞沉积和重塑的因素，这些因素反馈影响 肿瘤细胞的行为。尽管肿瘤微环境在肿瘤的发展过程中无疑是重要的 几种类型的癌症，针对微环境的治疗方法仍然罕见，在一定程度上， 因为这方面的知识还不够。因此，它是肿瘤微环境的使命 (TM)识别在肿瘤发生过程中发生的微环境变化并分析 肿瘤细胞和微环境成分之间的相互作用影响肿瘤的形成、生长、 进展，并最终转移。为了实现这些目标，TM项目促进了合作 它的32名成员来自17个部门-基础科学家、临床医生和专门从事 模拟体内环境的系统开发和系统级的计算建模 行为。TM项目研究分为三个主题领域：1)细胞外基质，2)工程 方法，以及3)免疫相互作用。计划成员获得了300万美元的直接成本支持 NCI资助和1,060万美元的直接费用，在同行审查的癌症相关支持总额中， 在最后一次赠款过程中，与494种出版物进行了卓有成效的合作。在这些出版物中，13%是内部出版的 方案协作和24%是方案间协作。仅在2016年，就有近 50%的出版物是与其他机构合作的。通过这些研究工作，委员会成员 TM计划正在识别新的生物标记物和治疗方法。

UWCCC Tumor Microenvironment (TM) Program Summary Co-Leaders: Patricia Keely and David Beebe PROJECT SUMMARY/ABSTRACT Tumors are complex systems composed of tumor cells, stromal cells, soluble factors, and the extracellular matrix (ECM); together, these components constitute the tumor microenvironment. While cancer research has focused historically on studying and treating the tumor cell, it is now clear that the other components of the tumor microenvironment are active participants in tumor progression. For example, growth factors secreted by tumor cells attract immune cells into the tumor microenvironment; these immune cells in turn provide cytokines and other factors that stimulate stromal cell deposition and remodeling of ECM, which feedback to influence tumor cell behavior. Although the tumor microenvironment is undoubtedly important in the progression of several types of cancer, therapeutic approaches targeted against the microenvironment remain rare, in part, because knowledge in this area is insufficient. Therefore, it is the mission of the Tumor Microenvironment (TM) Program to identify microenvironmental changes that occur during tumorigenesis and analyze how the interactions between the tumor cell and microenvironmental components affect tumor formation, growth, progression, and ultimately metastasis. To accomplish these goals, the TM program fosters collaborations between its 32 members from 17 departments - basic scientists, clinicians, and bioengineers who specialize in the development of systems that mimic the in vivo environment and computational modeling of systems-level behaviors. TM program research is organized into three thematic areas: 1) Extracellular Matrix, 2) Engineering Approaches, and 3) Immune Interactions. Program members were supported by $3.0 million direct costs in NCI-funding and $10.6 million direct costs in total peer-reviewed cancer-related support, and were highly productive with 494 publications during the course of the last grant. Of these publications, 13% were intra- programmatic collaborations and 24% were inter-programmatic collaborations. In the year 2016 alone, nearly 50% of publications were collaborative with other institutions. Through these research efforts, members of the TM program are identifying new biomarkers and therapeutic approaches.