An Online Short-Course in Sample-Size Determination - A Practical Guide to Improving Reproducibility through Proper Planning
样本量确定在线短期课程 - 通过适当规划提高再现性的实用指南
基本信息
- 批准号:9925089
- 负责人:
- 金额:$ 1.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:Active LearningAddressAdoptedAreaAttitudeBayesian MethodBehavioralBiomedical ResearchBudgetsCollectionCompetenceDevelopmentEducational CurriculumElementsEnsureEthicsExerciseFeedbackFosteringFoundationsFunctional Magnetic Resonance ImagingFundingGene Expression ProfilingGoalsHeadKnowledgeLearningMeasuresMethodologyMethodsModelingParticipantPre-Post TestsProblem SolvingProfessional OrganizationsPublishingReadingReproducibilityResearchResearch PersonnelSample SizeSamplingScienceSelf EfficacySlideStandardizationSystemTestingTrainingTraining ActivityTranslationsUnited States National Institutes of HealthWorkbasecohortimprovedjournal articlelearning materialslecturerlecturesonline coursepre-clinicalpre-clinical researchpublic health interventionsimulationsocial mediasoundtranscriptome sequencingwasting
项目摘要
Sample-size planning is currently the Achilles heel of biomedical research. Many fields of preclinical research
routinely rely on inadequate samples, leading to waste, excessive false-positives, and inflated effect sizes.
These practices persist because researchers often eschew sound sample-size planning for easy but invalid
approaches. To help address this critical issue, this project will produce a self-guided online course that will
help trainees exchange poor sample-size determination practices for sound approaches. The course will a)
help redirect researchers away from erroneous approaches by making clear their severe negative
consequences, b) will dispel common misconceptions that discourage sound sample-size planning, and c) will
provide exercises with instant feedback to build self-efficacy for independent sample-size planning. The
materials will be produced for a modest budget, will incorporate guidance from a team of renowned
methodological experts, and will be anchored in a proven behavioral-change approach. The course will
provide a needed supplement to current materials, which do not adequately teach sample-size determination.
A thoughtful piloting plan will enable extensive feedback from diverse stakeholders to ensure strong impact not
only on knowledge but also on attitudes and actual competency. Dissemination will be supported through
partnerships with professional societies and the extensive social media reach of the participating guest
lecturers. Funding this proposal can have a strong positive impact on rigor and reproducibility in preclinical
research.
样本量规划目前是生物医学研究的致命弱点。临床前研究的许多领域
通常依赖于不充分的样本,导致浪费,过多的假阳性和夸大的效应量。
这些做法之所以持续存在,是因为研究人员经常回避合理的样本规模规划,
接近。为了帮助解决这一关键问题,该项目将制作一个自我指导的在线课程,
帮助受训者改变不良的样本量确定做法,以采用合理的方法。本课程将a)
通过明确他们的严重负面影响,帮助引导研究人员远离错误的方法
结果,B)将消除阻碍合理样本量规划的常见误解,以及c)将
提供即时反馈的练习,以建立独立样本量规划的自我效能。的
材料将以适度的预算制作,将纳入一个著名的团队的指导,
这些人员将由一批方法专家组成,并将立足于行之有效的改变行为的办法。该课程将
对现有的材料提供必要的补充,这些材料没有充分教授样本量的确定。
一个深思熟虑的试点计划将使来自不同利益相关者的广泛反馈,以确保强大的影响,
不仅取决于知识,还取决于态度和实际能力。将通过以下方式支持传播工作:
与专业协会的合作伙伴关系以及参与嘉宾广泛的社交媒体影响力
讲师资助这项提案可以对临床前研究的严谨性和可重复性产生强烈的积极影响。
research.
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Better Inference in Neuroscience: Test Less, Estimate More.
神经科学中更好的推理:更少测试,更多估计。
- DOI:10.1523/jneurosci.1133-22.2022
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Calin-Jageman,RobertJ
- 通讯作者:Calin-Jageman,RobertJ
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Robert Joseph Calin-Jageman其他文献
Robert Joseph Calin-Jageman的其他文献
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{{ truncateString('Robert Joseph Calin-Jageman', 18)}}的其他基金
Mechanisms in the Expression and Decay of Long-Term Habituation Memory
长期习惯记忆的表达和衰退机制
- 批准号:
7939545 - 财政年份:2010
- 资助金额:
$ 1.79万 - 项目类别:
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