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Enhanced lithotripsy through coalescence and dispersion of cavitation bubbles

通过空化气泡的聚结和分散增强碎石术

基本信息

批准号：
9924525
负责人：
Timothy L Hall
金额：
$ 35.68万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-15 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9924525
关键词：
Acoustics Acute Adopted Adoption Adverse effects American Animals Attenuated Blood Tests Caliber Cell Nucleus Clinical Clinical Trials Complex Cystine Data Dose Effectiveness Electromagnetics Environment Extracorporeal Shockwave Lithotripsy Failure Family suidae Goals Grant Human Implant In Situ In Vitro Injury Injury to Kidney Intervention Kidney Laboratories Liquid substance Lithotripsy Location Magnetic Resonance Imaging Methods Modeling Operative Surgical Procedures Outcome Pain Pathway interactions Patients Procedures Process Proliferating Protocols documentation Radiation Recording of previous events Research Residual state Risk Role Safety Shock Soft Tissue Injuries System Techniques Testing Time Tissues Transducers Ultrasonic Transducer Ultrasonography Ureter Urinary Calculi Urine Work clinical translation design experimental study follow-up healing improved millisecond operation prevent safety study sound statistics success tissue injury tool

项目摘要

Abstract Extracorporeal shockwave lithotripsy (SWL) revolutionized the treatment of urinary stones when first introduced three decades ago. Instead of open stone surgery, acoustic energy could be applied from outside the body to fragment stones in situ. Although widely utilized for treatment of stones, SWL has not fully lived up to its potential. Incomplete fragmentation of stones can result in significant pain (when fragments migrate down the ureter and obstruct urine outflow) and a high rate of residual fragments that need subsequent additional therapy. SWL research has shown the complex role of acoustic cavitation in the stone comminution process. While cavitation has been demonstrated to be an essential component of the fragmentation process, the bubbles produced also interfere with subsequent shockwaves reducing their effectiveness and sometimes causing tissue injury. SWL treatments at extremely low rates (i.e. <30 shocks/min) have been shown in the laboratory to be substantially more efficient and cause less tissue injury because there is sufficient time for most of the cavitation bubbles to dissolve. However, ultra-low rates have not been adopted clinically because of the impractically long procedure times that would be required. We have previously demonstrated that unfocused low amplitude acoustic bursts can stimulate rapid coalescence and dispersion of cavitation bubbles during SWL clearing the pathway for subsequent shockwaves within tens of milliseconds. By this method we can recover the stone fragmentation efficiency and safety of very low shockwave rates at standard clinical rates. Initial studies outlined in this proposal are designed to optimize the bubble coalescence and dispersion process for use with a standard clinical electromagnetic shockwave lithotripsy system. The following studies will then demonstrate safety and improved efficacy on a porcine model such that a pilot clinical trial could be initiated following this work.

摘要

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Controlled cavitation to augment SWL stone comminution: mechanistic insights in vitro.

DOI：
10.1109/tuffc.2013.2566
发表时间：
2013-02
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
0
作者：
Duryea AP;Roberts WW;Cain CA;Hall TL
通讯作者：
Hall TL

Acoustic Methods for Increasing the Cavitation Initiation Pressure Threshold.

增加空化开始压力阈值的声学方法。

DOI：
10.1109/tuffc.2018.2867793
发表时间：
2018-11
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
0
作者：
Alavi Tamaddoni H;Duryea AP;Vlaisavljevich E;Xu Z;Hall TL
通讯作者：
Hall TL

Removal of Residual Cavitation Nuclei to Enhance Histotripsy Fractionation of Soft Tissue

DOI：
10.1109/tuffc.2015.007202
发表时间：
2015-12-01
期刊：
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
影响因子：
3.6
作者：
Duryea, Alexander P.;Cain, Charles A.;Hall, Timothy L.
通讯作者：
Hall, Timothy L.

Removal of residual cavitation nuclei to enhance histotripsy erosion of model urinary stones.

去除残余空化核，以增强模型尿石的组织疗法侵蚀。

DOI：
10.1109/tuffc.2015.7001
发表时间：
2015-05
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
0
作者：
Duryea AP;Roberts WW;Cain CA;Hall TL
通讯作者：
Hall TL

Enhanced High-Rate Shockwave Lithotripsy Stone Comminution in an In Vivo Porcine Model Using Acoustic Bubble Coalescence.

使用声学气泡聚结增强体内猪模型中的高速冲击波碎石碎石。

DOI：
10.1089/end.2016.0407
发表时间：
2016
期刊：
Journal of endourology
影响因子：
2.7
作者：
AlaviTamaddoni,Hedieh;Roberts,WilliamW;Duryea,AlexanderP;Cain,CharlesA;Hall,TimothyL
通讯作者：
Hall,TimothyL