Ischemic Brain Damage and Single Quantum Sodium MRI

项目总结 这项建议旨在评估组织钠浓度(TSC)的作用，如通过磁学测量 磁共振成像(MRI)，对急性脑缺血的处理。为了实现这一目标，我们将履行 介入治疗急性脑卒中患者再通治疗后20分钟内的MRI扫描 纽约大学医学院(NYUSOM)的神经放射服务。我们的基本假设 TSC大于65 mm的脑组织代表不能存活的组织，因此不能恢复 任何类型的再灌注治疗。这一假设得到了我们先前工作中的观察结果的证实 非人灵长类动物大脑中动脉可逆性闭塞的系列磁共振成像。这一假设 将通过比较严重抬高的TSC(超过65 mm)的空间联合配准体积来进行测试 每个研究对象的脑血管再通和脑梗塞体积(在30天的随访中)。我们 计划在这个五年计划期间招收总共120门学科，以考虑到 疾病，同时仍达到所需的统计意义。

PROJECT SUMMARY This proposal seeks to evaluate the role of tissue sodium concentration (TSC), as measured by magnetic resonance imaging (MRI), on the acute management of brain ischemia. To achieve this goal, we will perform MRI scans within 20 minutes of recanalization therapy on acute stroke patients treated in the Interventional Neuroradiology service at the New York University School of Medicine (NYUSOM). Our underlying hypothesis is that brain tissue with a TSC above 65mM represents non-viable tissue and, therefore, will not recover upon reperfusion therapy of any type. This hypothesis was borne out from observations during our previous work on serial MR imaging during reversible middle cerebral artery occlusion of non-human primates. This hypothesis will be tested by comparing the spatially co-registered volume of critically elevated TSC (above 65mM) after recanalization and the volume of infarction (on the 30 day follow up) on the brain of each study subject. We plan to enroll a total of 120 subjects during this five-year proposal in order to account for the heterogeneity of the disease while still attaining the required statistical significance.