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Ischemic Brain Damage and Single Quantum Sodium MRI

缺血性脑损伤和单量子钠 MRI

基本信息

批准号：
10605062
负责人：
Fernando E Boada
金额：
$ 53.07万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10605062
关键词：
Acute Animal Model Biological Markers Brain Brain Ischemia Brain scan Cause of Death Clinical Clinical Trials Coagulation Process Containment Country Development Diffusion Magnetic Resonance Imaging Effectiveness Eligibility Determination Enrollment Evolution Excision Exclusion Funding Goals Guidelines Human Imaging Techniques Infarction Injury Institution Intervention Ischemic Brain Injury Laboratories Lead Life MRI Scans Magnetic Resonance Imaging Measures Metabolic Middle Cerebral Artery Occlusion Modeling New York Observational Study Outcome Patients Perfusion Procedures Protons Reperfusion Therapy Research Personnel Risk Role Services Sodium Stroke Study Subject Testing Therapeutic Time Tissue Viability Tissues United States Universities Work acute stroke base brain tissue clinical heterogeneity diffusion weighted disability disease heterogeneity follow-up human subject improved outcome inclusion criteria ischemic injury medical schools nonhuman primate novel quantum stroke patient stroke therapy success tissue biomarkers tool

项目摘要

PROJECT SUMMARY This proposal seeks to evaluate the role of tissue sodium concentration (TSC), as measured by magnetic resonance imaging (MRI), on the acute management of brain ischemia. To achieve this goal, we will perform MRI scans within 20 minutes of recanalization therapy on acute stroke patients treated in the Interventional Neuroradiology service at the New York University School of Medicine (NYUSOM). Our underlying hypothesis is that brain tissue with a TSC above 65mM represents non-viable tissue and, therefore, will not recover upon reperfusion therapy of any type. This hypothesis was borne out from observations during our previous work on serial MR imaging during reversible middle cerebral artery occlusion of non-human primates. This hypothesis will be tested by comparing the spatially co-registered volume of critically elevated TSC (above 65mM) after recanalization and the volume of infarction (on the 30 day follow up) on the brain of each study subject. We plan to enroll a total of 120 subjects during this five-year proposal in order to account for the heterogeneity of the disease while still attaining the required statistical significance.

项目摘要该建议旨在评估组织钠浓度（TSC）的作用，如通过磁共振成像测量的。磁共振成像（MRI），对脑缺血的急性管理。为了实现这一目标，我们将介入治疗的急性卒中患者在再通治疗后20分钟内进行MRI扫描纽约大学医学院神经放射学服务。我们的基本假设具有高于65mM的TSC的脑组织代表无活力的组织，因此，任何类型的再灌注治疗。这一假设是从我们以前的工作中的观察中得到证实的。非人灵长类动物可逆性大脑中动脉闭塞期间的系列MR成像。这一假设将通过比较严重升高的TSC（高于65 mM）的空间共配准体积进行测试，再通和每个研究受试者脑上的梗死体积（在30天随访时）。我们计划在本五年计划期间共入组120例受试者，以考虑疾病，同时仍达到所需的统计学显著性。