Bio-medical and socio-economic precursors of cognitive decline in SHARE

SHARE认知能力下降的生物医学和社会经济先兆

• 批准号: 9925769
• 负责人: AXEL H BOERSCH-SUPAN
• 金额: $ 129.33万
• 依托单位: MAX PLANCK INST/SOCIAL LAW/SOCIAL POLICY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925769
• 关键词: Address; Affect; Age; Aging; Alzheimer' s Disease; Archives; Biological; Biological Assay; Biological Markers; Blood; Brain-Derived Neurotrophic Factor; Characteristics; Cholesterol; Cognition; Cognitive; Collection; Country; Data; Data Collection; Databases; Dementia; Denmark; Diagnosis; Early Intervention; Economic Conditions; Economic Factors; Education; Elderly; Environment; Europe; European; France; Funding; Germany; Glycosylated hemoglobin A; HDL-triglyceride; Hand Strength; Health; Health Surveys; Health and Retirement Study; Impaired cognition; International; Israel; Italy; Laboratories; Life; Life Cycle Stages; Lipids; Long-Term Care; Longitudinal Studies; Measurement; Measures; Mediating; Mental Health; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Participant; Pathway interactions; Patient Self-Report; Poland; Policies; Population; Prevalence; Prevention Measures; Preventive; Process; Proteins; Protocols documentation; Research Priority; Respondent; Retirement; Risk Factors; Running; Sampling; Sampling Studies; Social Environment; Spottings; Surveys; Symptoms; Testing; Universities; Variant; Vascular Dementia; Washington; World War II; base; blood lipid; care systems; cognitive testing; cytokine; design; health economics; instrument; instrumental activity of daily living; life history; mild cognitive impairment; mortality; post gamma-globulins; response; social; socioeconomics; user-friendly

PROJECT ABSTRACT The general aim of this project is to exploit the international variation of health and life circumstances in Continental Europe to identify which interactions of bio-medical and socio-economic conditions over the life course affect cognition in later life. The project will leverage the EU-funding of the Survey of Health, Aging and Retirement in Europe (SHARE) and addresses a number of key research priorities for NIA: The study of older adults in a diverse array of countries will provide valuable information on cognitive status and relate it to the socio-economic and social environment of the elderly as well as biomarkers that may serve as instruments to target early prevention measures. It will enhance our understanding how the vastly differing social, health and long-term care systems affect mental health and resulting mortality of the aging populations. This holds especially for the life circumstances in Europe since World War II which are likely to have influenced cognitive decline now at older ages. Moreover, the large variation in key policy variables, e.g. retirement age, identifies pathways from early retirement through inactivity and loss of social contacts to lower cognition, mediated by education, working environment and other socio-economic factors over the life-course. SHARE is a large population-representative panel study closely modeled after the US Health and Retirement Study (HRS) in currently 27 Continental European countries plus Israel. Strictly harmonized health variables for the about 80,000 respondents include self-reported health, functional health, physical measurements such as grip strength, peak flow and chair stand, and a large battery of tests for cognition and mental health. Moreover, SHARE has collected dried blood spot samples from some 27,000 respondents. The project will fill two strategic gaps in the harmonization between HRS and SHARE. It will 1. Administer an in-depth measurement of cognition according to the Harmonized Cognitive Assessment Protocol (HCAP) that has been developed for the HRS-style aging surveys supported by NIA. 2. Analyze the blood collected by SHARE for blood lipids and other biomarkers that have been found to correlate with cognitive decline, vascular dementia and Alzheimer's disease. Using these data, the project will estimate prevalence rates of mild and severe cognitive impairment in the SHARE countries; compare these with HRS and other participants in the HCAP studies; and exploit the international variation of the SHARE plus SHARE-HCAP data in order to identify which interactions of biomedical and socioeconomic conditions over the life course affect cognition later in life. This project is synchronized with the long-run agenda of the SHARE panel which has collected blood in wave 6, is currently administering a life-history module in Wave 7 and will feature an extended cognition module in Wave 8. Funding is restricted to the additional data collection efforts for SHARE-HCAP and the analyses of blood taken in wave 6 and in the SHARE-HCAP substudy for markers associated with cognitive decline.

项目摘要 该项目的总体目标是利用健康和生活环境的国际差异， 欧洲大陆，以确定生物医学和社会经济条件的相互作用，在生活中 影响到以后的认知能力。该项目将利用欧盟资助的健康、老龄化和 欧洲退休（SHARE）并解决了NIA的许多关键研究优先事项：老年人研究 不同国家的成年人将提供有关认知状况的宝贵信息，并将其与 老年人的社会经济和社会环境以及生物标志物， 采取早期预防措施。它将加强我们对巨大差异的社会、健康和 长期护理系统影响到老年人的心理健康，并导致老年人死亡。这适用 特别是对于二战以来欧洲的生活环境，这可能影响了人们的认知能力， 在年老时衰退。此外，关键政策变量（如退休年龄）的巨大差异表明， 从提前退休到缺乏活动和失去社会联系到认知能力降低的途径， 教育、工作环境和其他社会经济因素。 SHARE是一项大型人群代表性小组研究，密切模仿美国健康和退休 目前在27个欧洲大陆国家和以色列开展HRS研究。严格协调的健康变量 包括自我报告的健康，功能健康，身体测量， 如握力、峰值流量和椅子站立，以及一系列认知和心理健康测试。 此外，SHARE还从大约27，000名受访者中收集了干血斑样本。 该项目将填补HRS和SHARE之间协调方面的两个战略空白。它将 1.根据协调认知评估进行深入的认知测量 该协议（HCAP）是为NIA支持的HRS式老龄化调查开发的。 2.分析SHARE收集的血液中的血脂和其他生物标志物， 与认知能力下降、血管性痴呆和阿尔茨海默病有关。 利用这些数据，该项目将估计2010年至2011年美国轻度和重度认知障碍的患病率。 分享国家;与HRS和HCAP研究中的其他参与者进行比较;并利用 SHARE加上SHARE-HCAP数据的国际变化，以确定 生命过程中的生物医学和社会经济条件会影响以后的认知能力。 该项目与SHARE小组的长期议程同步，该小组已收集了大量血液， 目前正在管理Wave 7中的生活史模块，并将在Wave 7中提供扩展的认知模块。 第八波资金仅限于SHARE-HCAP的额外数据收集工作和对 在第6波和SHARE-HCAP子研究中采集血液，用于与认知下降相关的标志物。