Resource Dissemination and Outreach Center for Illuminating the Druggable Genome

项目摘要 尽管在开发新的治疗方法及其巨大的医疗和社会效益方面取得了稳步进展， 目前的药物仅靶向一小部分人类蛋白质组。即使是临床开发中的药物， 临床前药物发现研究忽略了可药用蛋白质组的重要部分。通过 开发、广泛传播和使用社区科学资源，IDG计划的重点是 推进研究人类蛋白质的研究，其中公开可用的信息或积极的研究是 目前缺乏，以促进新的生物学的发现，特别是对未充分研究的 蛋白激酶、离子通道和非嗅觉GPCR家族的成员。 我们来自新墨西哥州大学和迈阿密大学的高度协调的团队已经建立了 IDG 生成 IDG-RDOC与所有IDG联盟调查员合作， 整理有关IDG联盟正在开发的关键工具和试剂的信息， 通过IDG门户网站进行传播。具体而言，我们：（i）通过一个 （二）促进和协调外部伙伴关系、外联活动， 与IDG计划活动相关的培训;以及（iii）制定和实施数据标准、政策、运营， 收集、管理、识别和传播IDG生成的资源的工具（扩展） NIH FAIR（Findable，Interoperable，Releasable，Attributable，Interoperable，Reusable，Reproducible）原则 通过拟议的补充，我们将按照 NIH计划，但由于预算限制，最初没有提出。特别是，我们将实施和 支持动态蛋白质照明时间轴（PIT）和所需的基础设施和工艺， 关于未充分研究的蛋白质的照明的财团的通信进展的机制 并提供IDG生成的与未充分研究的蛋白质相关的资源的信息。 资源传播和推广中心（RDOC），以促进广泛获得联盟- 数据和资源，并为IDG联盟及其 与外部合作伙伴。 1

PROJECT SUMMARY Despite steady progress in developing novel therapeutics and their enormous medical and societal benefits, current drugs target only a small fraction of the human proteome. Even drugs in clinical development and most preclinical drug discovery research ignore a significant portion of the druggable proteome. Through the development, broad dissemination, and use of community scientific resources, the IDG program is focused on advancing research to study human proteins for which publicly available information or active research is currently lacking, in order to catalyze the discovery of novel biology with a particular focus on understudied members of the protein kinase, ion channel, and non-olfactory GPCR families. Our highly-coordinated team from the University of New Mexico and the University of Miami has established the IDG generated relationships The IDG-RDOC works with all IDG Consortium investigators to collect and curate information regarding critical tools and reagents being developed by the IDG Consortium and disseminate them through the IDG Portal. Specifically we: (i) coordinate and support the IDG consortium via a highly experienced administrative team; (ii) facilitate and coordinate external partnerships, outreach, and training related to IDG program activities; and (iii) develop and implement data standards, policies, operations, and tools to collect, curate, identify, and disseminate IDG-generated resources in accordance with (extended) NIH FAIR (Findable, Accessible, Attributable, Interoperable, Reusable, Reproducible) principles. Via the proposed supplement, we will significantly expand the capabilities of the RDOC as requested by the NIH program, but not originally proposed due to budgetary constraints. In particular we will implement and support a dynamic Protein Illumination Timeline (PIT) and required infrastructure and processes as a primary mechanism of communicating progress of the consortium regarding the illumination of understudied proteins and to provide access to information of IDG-generated resources related to understudied proteins. Resource Dissemination and Outreach Center (RDOC) to facilitate widespread access to consortium- data and resources as well as to serve the overall administration of the IDG Consortium and its with external partners. 1