Resource Dissemination and Outreach Center for Illuminating the Druggable Genome

阐明可药物基因组的资源传播和外展中心

• 批准号: 9932594
• 负责人: TUDOR I OPREA
• 金额: $ 19.61万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9932594
• 关键词: Access to Information; Biological; Biology; Communities; Data; Development; Disease; Drug Targeting; Family; G-Protein-Coupled Receptors; Genome; Human; Infrastructure; Ion Channel; Lighting; Medical; New Mexico; Pharmaceutical Preparations; Policies; Process; Protein Kinase; Proteins; Proteome; Reagent; Reproducibility; Research; Research Personnel; Resources; TimeLine; Training; Training Programs; United States National Institutes of Health; Universities; Work; clinical development; data resource; drug discovery; experience; improved; interoperability; member; novel; novel therapeutics; operation; outreach; outreach program; pre-clinical; programs; success; tool

PROJECT SUMMARY Despite steady progress in developing novel therapeutics and their enormous medical and societal benefits, current drugs target only a small fraction of the human proteome. Even drugs in clinical development and most preclinical drug discovery research ignore a significant portion of the druggable proteome. Through the development, broad dissemination, and use of community scientific resources, the IDG program is focused on advancing research to study human proteins for which publicly available information or active research is currently lacking, in order to catalyze the discovery of novel biology with a particular focus on understudied members of the protein kinase, ion channel, and non-olfactory GPCR families. Our highly-coordinated team from the University of New Mexico and the University of Miami has established the IDG generated relationships The IDG-RDOC works with all IDG Consortium investigators to collect and curate information regarding critical tools and reagents being developed by the IDG Consortium and disseminate them through the IDG Portal. Specifically we: (i) coordinate and support the IDG consortium via a highly experienced administrative team; (ii) facilitate and coordinate external partnerships, outreach, and training related to IDG program activities; and (iii) develop and implement data standards, policies, operations, and tools to collect, curate, identify, and disseminate IDG-generated resources in accordance with (extended) NIH FAIR (Findable, Accessible, Attributable, Interoperable, Reusable, Reproducible) principles. Via the proposed supplement, we will significantly expand the capabilities of the RDOC as requested by the NIH program, but not originally proposed due to budgetary constraints. In particular we will implement and support a dynamic Protein Illumination Timeline (PIT) and required infrastructure and processes as a primary mechanism of communicating progress of the consortium regarding the illumination of understudied proteins and to provide access to information of IDG-generated resources related to understudied proteins. Resource Dissemination and Outreach Center (RDOC) to facilitate widespread access to consortium- data and resources as well as to serve the overall administration of the IDG Consortium and its with external partners. 1

项目总结 尽管在开发新疗法及其巨大的医疗和社会效益方面取得了稳步进展， 目前的药物只针对人类蛋白质组的一小部分。甚至临床开发中的药物和大多数 临床前药物发现研究忽略了可药物蛋白质组的很大一部分。通过 开发、广泛传播和使用社区科学资源，IDG计划的重点是 正在推进研究人类蛋白质的研究，这些蛋白质的公开信息或活跃研究是 目前缺乏，以催化新生物学的发现，特别关注未被研究的 蛋白激酶、离子通道和非嗅觉GPCR族的成员。 我们来自新墨西哥大学和迈阿密大学的高度协调的团队已经建立了 《IDG》 已生成 IDG-RDoC与所有IDG财团调查人员合作收集和 整理有关IDG联盟正在开发的关键工具和试剂的信息，并 通过IDG门户网站进行传播。具体地说，我们：(I)通过 经验丰富的行政团队；(2)促进和协调外部伙伴关系、外联和 与IDG计划活动有关的培训；以及(3)制定和实施数据标准、政策、业务、 和工具，用于收集、整理、识别和传播IDG生成的资源(扩展) NIH公平(可发现、可访问、可归因性、可互操作、可重复使用、可重复使用)原则。 透过建议的补充资料，我们会按 NIH计划，但由于预算限制，最初并未提出。特别是，我们将实施和 支持动态蛋白质照明时间表(PIT)和所需的基础设施和流程作为主要 该联合体关于未研究蛋白质光照进展的沟通机制 并提供IDG生成的与未被研究的蛋白质相关的资源的信息。 资源传播和外联中心(RDoC)，以促进广泛接触财团- 数据和资源，并为IDG财团及其 与外部合作伙伴合作。 1