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Functional neuroanatomy of social and perceived internal threat in anxious youth at high-risk for bipolar disorder

双相情感障碍高危焦虑青少年的社会和感知内部威胁的功能神经解剖学

基本信息

批准号：
9927709
负责人：
Donna J Roybal
金额：
$ 19.01万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-06-01 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9927709
关键词：
Academy Adolescent Psychiatry Affect American Amygdaloid structure Anterior Anxiety Anxiety Disorders Area Award Behavior assessment Belief Biological Biological Markers Biometry Bipolar Disorder Brain Characteristics Child Child Psychiatry Cognitive Corpus striatum structure Cues Development Developmental Course Dorsal Emotional Environment Evaluation Exhibits Feedback Feeling Fostering Foundations Functional Magnetic Resonance Imaging Goals Health Sciences Hippocampus (Brain)Insula of Reil Investigation Knowledge Measures Mental Depression Mental Health Mentorship Mood Disorders Moods Neuroanatomy Outcome Perceived quality of life Pilot Projects Prefrontal Cortex Research Sample Size Schools Social Behavior Social Interaction Solid Source Structure Structure of middle temporal gyrus Substance abuse problem Suicide Symptoms Testing Texas Training Training Programs Universities Youth anxious career cingulate cortex cognitive process comorbidity emotion regulation experience high risk high risk population improved mood symptom multimodality neural circuit neural model neuroimaging offspring prevent psychosocial relating to nervous system social social anxiety social cognition social relationships treatment response virtual

项目摘要

Project Summary/Abstract The purpose of this K23 application is to support my short-term career objectives of acquiring multimodal neuroimaging, neurocomputational, biostatistical, and theoretical social cognitive knowledge in the study of anxiety and emotion regulation in youth at high-risk for bipolar disorder (BD). Longitudinal evidence suggests that youth at high-risk for BD that develop any mood disorder experience an anxiety disorder as an early antecedent. Anxiety is therefore an important symptom in the developmental trajectory of BD. One of the largest sources of anxiety in youth is the quality of social relationships, which greatly influence youth's perceived quality of life. However, little is known about the neural underpinnings of social cognition in youth at high-risk for BD or how everyday social interactions affect anxiety and emotion regulation, which is a hallmark characteristic of BD. In a previous pilot study (P.I. Roybal, American Academy of Child and Adolescent Psychiatry/Lilly Pilot Research Award), I showed differences in brain activation and functional connectivity between youth with BD relative to healthy controls (HC) when both groups experienced a functional magnetic resonance imaging (fMRI) social rejection task. I applied this fMRI social rejection task to youth at high-risk for BD (P.I. Roybal, Hogg Foundation for Mental Health). The research proposed here will add to the sample size of this high-risk group (HR) as it proposes to use the same fMRI social rejection task and add on an fMRI task evaluating perceived internal threat subsequent to social rejection. Behavioral assessments and fMRI will be used to assess functional neuroanatomical correlates in the HR group. Our hypotheses predict that the HR group will have functional neural deficits relative to HC during a social rejection task that involve regions salient to social rejection, specifically subgenual anterior cingulate cortex and anterior insula, but also will involve limbic areas not typically seen in social rejection, specifically the amygdala and hippocampus. We hypothesize that within the HR group, hyperactivation and abnormal connectivity observed during the social rejection task will correlate with subsequent anxiety felt after experiencing social rejection. We will also examine the effects of social rejection on internal threat cues that affect mood. We hypothesize the HR group will exhibit greater amygdala activation and weaker functional connectivity between amygdala and prefrontal cortex, a structure theorized to regulate the amygdala, relative to HC. Within the HR group, abnormal activation and connectivity will be correlated with the ability to emotionally self-regulate. Both treating youth with and at high-risk for BD and having basic neuroimaging experience have laid a solid foundation for me to achieve my training goals and complete this study. The proposed integrated research, mentorship, and didactic training programs, combined with the outstanding research environment at the University of Texas Health Science Center at San Antonio, will foster my long-term career objective of being a leading expert in multimodal social cognitive neural models as they relate to anxiety and emotion regulation in children at high-risk for BD.

项目总结/文摘