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Methods for Assessing Lesion Depth and Severity with Near-IR Light

用近红外光评估病变深度和严重程度的方法

基本信息

批准号：
9926718
负责人：
Jacob Carmody Simon
金额：
$ 4.7万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2021-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9926718
关键词：
3-Dimensional Affect Algorithms Anti-Bacterial Agents Appearance Area Chronic Disease Clinical Clinical Data Data Dental Dental Enamel Dental caries Dentin Dentistry Development Devices Diagnosis Disease Fluorides Hand Health Histologic Image Imaging technology In Vitro Intervention Lasers Lesion Light Lighting Measurement Measures Methods Microradiography Miniaturization Modeling Monitor Monte Carlo Method Operative Surgical Procedures Optical Coherence Tomography Optical Methods Optics Pathology Polarization Microscopy Process Production Radiation exposure Research Risk Roentgen Rays Severities Source Stains Surface Techniques Technology Testing Thick Time Tissues Tooth structure Transillumination Variant Visualization Water Work absorption accurate diagnosis attenuation base clinical imaging cost demineralization design experimental study image processing imaging probe imaging study improved in vivo instrument irradiation light scattering millimeter miniaturize multimodality novel diagnostics optical imaging outreach portability public health relevance remineralization screening sound tool transmission process

项目摘要

DESCRIPTION (provided by applicant): The overall objective of this proposed research is to advance the ability of near-IR (NIR) imaging to assess the depth and severity of carious lesions (dental decay). If diagnosed during early stages in the disease process, caries progression can be arrested/remineralized by non-surgical means through fluoride therapy, anti-bacterial therapy, or by low intensity laser irradiation. Clinicians need new imaging technologies that function using non- ionizing light and that aid in caries diagnosis and management/intervention by reliably tracking the pathology of carious lesions, from their initial stages until cavitation, n order to determine if the lesion is actively expanding or has been arrested. Light scattering in sound enamel and dentin is the principal factor limiting optical transmission through the tooth in the visible range from 400-700-nm. Light scattering in enamel decreases as the wavelength increases (1/λ3), where λ represents the wavelength, due to the size of the principal light scatters1,3. The central hypothesis motivating this application is that the near-infrared region from 1300- 1700-nm holds the greatest potential for new optical imaging technologies due to markedly increased optical transmission and multispectral differences in water absorption. Previous in vitro and in vivo studies have demonstrated that NIR reflectance and transillumination images work best using different optimal wavelengths within the NIR spectral region, due to varying attenuation from water absorption and endogenous differences in water content among dental hard tissues4-6. The overall objectives of this application will be achieved through the following specific aims. (1) To test the hypothesis that multispectral NIR reflectance and transillumination measurements of occlusal carious lesions can be combined for improved assessment of lesion depth and severity. (2) To test the hypothesis that multispectral NIR reflectance measurements can be used to detect interproximal carious lesions viewed from the occlusal surface. The successful completion of this project is likely to substantially advance clinical dentistry by providing the necessary technology to detect early stages of caries and quantitatively monitor their progression. Furthermore, because there are no health risks from imaging with NIR light, and this technology can be miniaturized into NIR imaging probes at low cost, NIR imaging has the potential to be a universal caries screening method used globally and routinely to detect dental decay.

描述（由申请人提供）：这项拟议研究的总体目标是提高近红外（NIR）成像评估龋损（龋齿）深度和严重程度的能力。如果在疾病过程的早期阶段被诊断出，龋齿的进展可以通过非手术手段，如氟化物治疗、抗菌治疗或低强度激光照射来阻止/阻止。临床医生需要新的成像技术，其使用非电离光起作用，并且通过可靠地跟踪龋齿病变的病理学来帮助龋齿诊断和管理/干预，从它们的初始阶段直到空化，以便确定病变是否正在积极扩展或已经被阻止。在健康牙釉质和牙本质中的光散射是限制在400-700 nm的可见光范围内通过牙齿的光透射的主要因素。由于主要光散射的大小，釉质中的光散射随着波长的增加而减少（1/λ3），其中λ表示波长1，3。推动这一应用的中心假设是，由于水吸收的光透射率和多光谱差异显着增加，1300- 1700 nm的近红外区域拥有新的光学成像技术的最大潜力。先前的体外和体内研究已经证明，由于水吸收的不同衰减和牙齿硬组织中含水量的内源性差异4 -6，使用NIR光谱区域内的不同最佳波长，NIR反射和透照图像效果最好。本申请的总体目标将通过以下具体目标实现。(1)为了验证这一假设，即多光谱近红外反射和透照测量的咬合面龋损可以结合起来，以改善评估病变的深度和严重程度。(2)检验多光谱近红外反射率测量可用于检测从咬合面观察的邻间龋损的假设。该项目的成功完成可能会通过提供必要的技术来检测龋齿的早期阶段并定量监测其进展，从而大大推进临床牙科。此外，由于使用NIR光成像没有健康风险，并且该技术可以以低成本小型化为NIR成像探针，因此NIR成像有可能成为全球通用的龋齿筛查方法，并常规用于检测龋齿。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Dual short wavelength infrared transillumination/reflectance mode imaging for caries detection.

DOI：
10.1117/1.jbo.26.4.043004
发表时间：
2021-01
期刊：
Journal of biomedical optics
影响因子：
3.5
作者：
Zhu Y;Abdelaziz M;Simon J;Le O;Fried D
通讯作者：
Fried D

Compact in vivo handheld dual SWIR transillumination/reflectance imaging system for the detection of proximal and occlusal lesions.

紧凑型体内手持式双短波红外透照/反射成像系统，用于检测近端和咬合病变。

DOI：
10.1117/12.2584903
发表时间：
2021
期刊：
Proceedings of SPIE--the International Society for Optical Engineering
影响因子：
0
作者：
Zhu,Yihua;Simon,Jacob;Ng,Chung;Fried,Daniel
通讯作者：
Fried,Daniel

Caries inhibition of simulated active caries lesions with CO2 laser irradiation and fluoride.

CO2 激光照射和氟化物对模拟活动性龋齿病变的龋齿抑制作用。

DOI：
10.1117/12.2608308
发表时间：
2022
期刊：
Proceedings of SPIE--the International Society for Optical Engineering
影响因子：
0
作者：
Tressel,John;Kashirtsev,Filipp;Cheung,Kevin;Simon,Jacob;Fried,Daniel
通讯作者：
Fried,Daniel

Thermal Imaging of Root Caries In Vivo.

体内根龋热成像。

DOI：
10.1177/0022034520951157
发表时间：
2020
期刊：
Journal of dental research
影响因子：
7.6
作者：
Yang,V;Zhu,Y;Curtis,D;Le,O;Chang,NYN;Fried,WA;Simon,JC;Banan,P;Darling,CL;Fried,D
通讯作者：
Fried,D

Multispectral SWIR images of the pulp-chamber of posterior teeth in vitro.

体外后牙牙髓腔的多光谱短波红外图像。