Envelope Immunogen and Recombinant Antibody Production Core

包膜免疫原和重组抗体生产核心

• 批准号: 9927544
• 负责人: Leonidas Stamatatos
• 金额: $ 4万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-05 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9927544
• 关键词: Antibodies; Antibody Formation; Antigens; Biochemical; Cell Line; Development; HIV; HIV-1; HIV-1 vaccine; Immunization; Infection; Instruction; Production; Proteins; Protocols documentation; Reagent; Receptors, Antigen, B-Cell; Recombinant Antibody; Recombinants; Research Activity; Research Project Grants; Science; System; Vaccination; Vaccines; Validation; Virus; base; design; env Gene Products; immunogenicity; neutralizing antibody; pre-clinical; vaccine trial

The Science Core B will support activities in all four projects of this IPCAVD Proposal. Core B will be responsible for the production of protein reagents and vaccine immunogens that will be used in Projects One, Two, and Three. Core B will be responsible for the production of recombinant Envelope proteins for analytical studies in Project One, and the production of the Envelope-based immunogens that will be used in for pre-clinical vaccine studies in Project Two. Additionally, Core B will assist in the development of stable protein production cell lines and analytical validation of stably-produced Envelope immunogens in Project Three.

科学核心B将支持IPCAVD提案中所有四个项目的活动。核心B将是 负责项目中使用的蛋白试剂和疫苗免疫原的生产 一二三核心B将负责生产重组包膜蛋白， 项目一的分析研究，以及将用于 用于项目二的临床前疫苗研究。此外，核心B将协助开发稳定的 蛋白生产细胞系和项目中稳定生产的包膜免疫原的分析验证 三.