Clinical Core

临床核心：总结/摘要： 该计划项目补助金（PPG）的临床核心是 负责PPG中入组的所有受试者的认知和临床评价。临床 核心协调和进行神经心理测试，神经系统检查，收集病史 数据，管理抑郁症症状问卷，并完成有关和评级水平的访谈 参与者的日常活动。这些信息用于进行认知诊断分类 在衰老中，特别是正常认知与轻度认知障碍与痴呆。临床核心 通过多学科共识会议分配诊断类别，它在一个双向的组织， 每周的基础上。项目1、2、3和4使用诊断类别和认知测量进行初始评估。 研究筛选和PPG目标中的关键认知结局。临床核心转移所有 认知和临床数据收集到成像，方法和统计核心，并协助 将临床数据与神经成像数据合并。最后，临床核心将招募和协调新的 支持项目3的尸检案件。

Clinical Core: Summary/Abstract: The Clinical Core of the Program Project Grant (PPG) is responsible for cognitive and clinical evaluations for all participants enrolled in the PPG. The Clinical Core coordinates and conducts neuropsychological testing, neurological exams, collects medical history data, administers depression symptom questionnaires, and completes interviews about and rates levels of daily functioning of participants. This information is used to make cognitive diagnostic classifications in aging, specifically normal cognition vs. mild cognitive impairment vs. dementia. The Clinical Core assigns diagnostic categories via a multidisciplinary consensus conference, which it organizes on a bi- weekly basis. Diagnostic categories and cognitive measures are used by Projects 1, 2, 3, and 4 for initial study screening and as key cognitive outcomes in the Aims of the PPG. The Clinical Core transfers all cognitive and clinical data collected to the Imaging, Methodology and Statistics Core and assists in merging clinical data with neuroimaging data. Finally the Clinical Core will recruit and coordinate new autopsy cases in support of Project 3.