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Clinical Core

临床核心

基本信息

批准号：
9927983
负责人：
BETH SNITZ
金额：
$ 20.6万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9927983
关键词：
Activities of Daily Living African American Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease pathology Amyloid beta-Protein Autopsy Blood Vessels Categories Classification Clinical Clinical Data Clinical assessments Clinical dementia rating scale Cognition Cognitive Cohort Studies Consensus Consent Data Dementia Diagnosis Diagnostic Elderly Enrollment Ensure Evaluation Evaluation Studies Functional disorder Ginkgo biloba Goals Heart Home visitation Image Infrastructure Interview Logistics Longitudinal Studies Measures Medical Medical History Memory Methodology Monitor Nerve Degeneration Neurologic Neurological status Neuropsychological Tests Neuropsychology Normal Range Outcome Parents Participant Pathology Patients Performance Pharmaceutical Preparations Positron-Emission Tomography Program Research Project Grants Questionnaires Reporting Risk Sampling Standardization Synapses Telephone Time Universities Validation Visit adjudicate arterial stiffness base cardiovascular risk factor clinical imaging clinical phenotype clinically relevant cognitive performance cognitive testing cohort daily functioning depressive symptoms follow-up human subject informant middle age mild cognitive impairment mortality multidisciplinary neuroimaging non-demented operation organizational structure programs racial disparity recruit research clinical testing screening statistics symposium tau Proteins

项目摘要

Clinical Core: Summary/Abstract: The Clinical Core of the Program Project Grant (PPG) is responsible for cognitive and clinical evaluations for all participants enrolled in the PPG. The Clinical Core coordinates and conducts neuropsychological testing, neurological exams, collects medical history data, administers depression symptom questionnaires, and completes interviews about and rates levels of daily functioning of participants. This information is used to make cognitive diagnostic classifications in aging, specifically normal cognition vs. mild cognitive impairment vs. dementia. The Clinical Core assigns diagnostic categories via a multidisciplinary consensus conference, which it organizes on a bi- weekly basis. Diagnostic categories and cognitive measures are used by Projects 1, 2, 3, and 4 for initial study screening and as key cognitive outcomes in the Aims of the PPG. The Clinical Core transfers all cognitive and clinical data collected to the Imaging, Methodology and Statistics Core and assists in merging clinical data with neuroimaging data. Finally the Clinical Core will recruit and coordinate new autopsy cases in support of Project 3.

临床核心：摘要/摘要：该计划项目拨款(PPG)的临床核心是负责所有参加PPG的参与者的认知和临床评估。《临床》 CORE协调并进行神经心理测试、神经学检查、收集病史数据，管理抑郁症状问卷，并完成关于水平和评级的访谈参与者的日常运作情况。此信息用于进行认知诊断分类在衰老中，特别是正常认知与轻度认知障碍与痴呆症。临床核心通过多学科共识会议分配诊断类别，该会议在两个月内组织每周一次。诊断类别和认知测量由项目1、2、3和4用于初始研究筛选和作为PPG目标中的关键认知结果。临床核心将所有将认知和临床数据收集到成像、方法和统计核心，并协助将临床数据与神经影像数据合并。最后，临床核心将招聘和协调新的支持项目3的尸检案例。