Clinical Core

临床核心摘要/摘要 该计划的临床核心项目赠款(PPG)提供了临床、认知和 认知诊断裁决，以及过去三个周期的协调尸检 PPG。对于PPG的第四个周期(PPG4)，临床核心继续承担这一关键责任 提供对目标和目标至关重要的临床和认知诊断分类 项目的假设。临床核心主要负责招募参与者， 临床评估和尸检协调。临床核心将招募300名以上的老年人 头两年，并进行年度临床和认知评估。临床评估 包括年度神经心理测试、病史和神经学检查，以及 对功能、行为和情绪的评估，所有这些都将用于对 支持项目1、2、3和4的认知诊断分类。认知诊断是 在每两周一次的诊断病例会议上由来自 临床核心。临床核心还进行血管风险评估(动脉僵硬， 颈动脉超声和血管内皮功能测量)和睡眠(睡眠 日记、活动记录和多导睡眠图)在基线、24个月和48个月，以支持 项目1和2.临床核心与成像生物标记物和方法核心合作 和流体生物标记物和方法核心，提供参与者和协调 将由这些公司获得的成像和生物流体生物标志物数据的调度和后勤 各自的核心。临床核心将所有临床、认知、行为、血管和 将睡眠数据发送到生物统计和数据管理核心，并协助合并这些数据 影像和流体生物标记物数据。最后，根据先前的协调经验 验尸个案，临床核心确认临时验尸意向，并协调 为支持项目4的任何新尸检案件提供后勤服务。

Clinical Core Summary/Abstract The Clinical Core of the Program Project Grant (PPG) has provided clinical, cognitive and cognitive diagnostic adjudications, and coordinated autopsies for the past three cycles of the PPG. For the 4th cycle of the PPG (PPG4), the Clinical Core continues this crucial responsibility providing clinical and cognitive diagnostic classifications that are critical to the aims and hypotheses of the Projects. The Clinical Core is primarily responsible for participant recruitment, clinical evaluation and autopsy coordination. The Clinical Core will recruit 300 older adults over the first two years and conduct annual clinical and cognitive assessments. Clinical assessments include annual neuropsychological testing, medical history and neurological examination, and assessments of function, behavior and mood, all of which will be used in the adjudication of cognitive diagnostic classifications in support of Projects 1, 2, 3 and 4. Cognitive diagnoses are adjudicated at biweekly diagnostic case conferences by a multi-disciplinary team from the Clinical Core. The Clinical Core also conducts assessments of vascular risk (arterial stiffness, carotid artery ultrasonography, and vascular endothelial function measures) and sleep (sleep diary, actigraphy, and polysomnography) at baseline, and 24- and 48-months, in support of Projects 1 and 2. The Clinical Core works with the Imaging Biomarker and Methodology Core and the Fluid Biomarker and Methodology Core, providing participants and coordinating scheduling and logistics for imaging and biofluid biomarker data to be obtained by these respective Cores. The Clinical Core transfers all clinical, cognitive, behavioral, vascular and sleep data to the Biostatistics and Data Management Core, and assists in merging these data with the imaging and fluid biomarker data. Finally, building on prior experience in coordinating autopsy cases, the Clinical Core confirms provisional autopsy intent and coordinates the logistics for any new autopsy cases in support of Project 4.