Low cost and high performance time-of-flight PET detectors
低成本、高性能飞行时间 PET 探测器
基本信息
- 批准号:9974310
- 负责人:
- 金额:$ 53.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:AcademiaAddressAnodesAreaBismuthCathodesCharacteristicsClinicalCoupledCrystallizationDataDetectionDevelopmentDoseElectric CapacitanceElectronicsElementsEventHot SpotImageImage EnhancementImaging PhantomsIndustryLengthLesionLightLutetiumMeasurementMeasuresModernizationMonte Carlo MethodNamesNeoplasm MetastasisNoisePathway interactionsPatientsPerformancePhotonsPlayPositron-Emission TomographyPredispositionProbabilityRadiation Dose UnitRecoveryResolutionRoleScanningShapesSignal TransductionSiliconSystemTechniquesTechnologyTemperatureTimeTracerViolaVisualizationabsorptionadvanced systemanalogbasecostcost effectivedensitydesigndetectordigitalimaging studyimprovedinstrumentationinterestluminescencemetermodels and simulationnoveloperationphotomultiplierphoton-counting detectorresponsesignal processingtrenduptake
项目摘要
Project Summary/Abstract
There is a major push to substantially improve the sensitivity of positron emission tomography (PET) with
systems comprising increased crystal volume and detectors with fast timing capabilities to better exploit 511
keV photon localization with time-of-flight PET (TOF-PET). For these efforts, there is a vital need for advances
in TOF-PET detector technologies that provide excellent coincidence time resolution (CTR) and 511 keV
photon detection efficiency at reduced cost. To address this, we propose to leverage novel readout electronics
that optimize the single photon response shape and single photon time resolution (SPTR) of silicon
photomultipliers (SiPMs) to accurately estimate 511 keV photon time of interaction with the mixed
Cherenkov/luminescence (MCL) yield from bismuth germinate (BGO). SPTR does not strongly influence CTR
for fast and bright scintillators, such as lutetium orthosilicate scintillators (LSO/LYSO). However, a moderate
Cherenkov yield mixed with a weak luminescence response creates a more unique scenario where SPTR and
single photon response shape play a major role in achievable CTR. With our electronic readout, <285 ps
FWHM CTR is achievable for long and narrow BGO crystal elements suitable for clinical PET detectors. This is
equivalent to CTR achieved by state-of-the-art (SoA) commercial PET detectors. The novel signal multiplexing
strategies we propose to develop will allow us to maintain SoA CTR performance in large area detector
modules at the same or reduced channel density than conventional TOF-PET detector designs. BGO is an
extremely economical detector material, with a cost that is 4-to-5 fold lower than the standard LSO/LYSO
scintillators used in all modern TOF-PET systems. We will develop TOF-PET detector modules with associated
front-end signal processing and digital readout electronics. The technology will be ready for “plug-and-play”
integration into reduced cost clinical TOF-PET systems and those that aim to explore ultra-sensitive PET
systems with increased detection volume at reduced cost. The proposed PET detector technologies can have
a significant impact on quantitative PET imaging. The image signal-to-noise-ratio enabled by the enormous
boost in counts from high sensitivity PET systems can be employed to substantially reduce tracer dose and
shorten scan time/increase patient throughput, or to better visualize and quantify smaller lesions/features in the
presence of significant background, which are important features that can make PET more practical and lower
cost, as well as help to expand its roles in patient management.
项目总结/摘要
存在实质上提高正电子发射断层扫描(PET)的灵敏度的主要推动力,
包括增加的晶体体积和具有快速定时能力的检测器的系统,以更好地利用511
利用飞行时间PET(TOF-PET)的keV光子定位。对于这些努力,
在TOF-PET探测器技术中,
以降低的成本提高光子探测效率。为了解决这个问题,我们建议利用新型读出电子器件
优化硅的单光子响应形状和单光子时间分辨率(SPTR)
光电倍增管(SiPM),以准确估计511 keV光子与混合
锗酸铋(BGO)的切伦科夫/发光(MCL)产率。SPTR对CTR的影响不大
用于快速和明亮的蒸发器,如硅酸镥蒸发器(LSO/LYSO)。然而,一个温和的
Cherenkov产率与弱发光响应混合产生了更独特的场景,其中SPTR和
单光子响应形状在可实现CTR中起主要作用。使用我们的电子读数,<285 ps
对于适用于临床PET探测器的长而窄的BGO晶体元件,可以实现FWHM CTR。这是
与最先进的(SoA)商用PET探测器实现的CTR相当。新型信号复用
我们建议开发的策略将使我们能够在大面积探测器中保持SoA CTR性能
模块的通道密度与传统TOF-PET探测器设计相同或更低。BGO是一个
非常经济的探测器材料,成本比标准LSO/LYSO低4-5倍
用于所有现代TOF-PET系统的蒸发器。我们将开发TOF-PET探测器模块,
前端信号处理和数字读出电子设备。该技术将为“即插即用”做好准备
集成到降低成本的临床TOF-PET系统和旨在探索超灵敏PET的系统中
以降低的成本增加检测体积的系统。所提出的PET探测器技术可以具有
对定量PET成像有重大影响。图像信噪比由巨大的
可以采用来自高灵敏度PET系统的计数的增加来显著减少示踪剂剂量,
缩短扫描时间/增加患者吞吐量,或更好地可视化和量化
存在显著的背景,这是可以使PET更实用和更低成本的重要特征。
成本,以及帮助扩大其在病人管理中的作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Joshua William Cates其他文献
Joshua William Cates的其他文献
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{{ truncateString('Joshua William Cates', 18)}}的其他基金
Machine Learning with Scintillation Photon Counting Detectors to Advance PET Imaging Performance
利用闪烁光子计数探测器进行机器学习以提高 PET 成像性能
- 批准号:
10742435 - 财政年份:2023
- 资助金额:
$ 53.05万 - 项目类别:
Scintillation Photon Counting Detectors for 100 ps Time-of-Flight PET Imaging
用于 100 ps 飞行时间 PET 成像的闪烁光子计数探测器
- 批准号:
10504849 - 财政年份:2022
- 资助金额:
$ 53.05万 - 项目类别:
Scintillation Photon Counting Detectors for 100 ps Time-of-Flight PET Imaging
用于 100 ps 飞行时间 PET 成像的闪烁光子计数探测器
- 批准号:
10704157 - 财政年份:2022
- 资助金额:
$ 53.05万 - 项目类别:
Clinical Imaging Performance Evaluation of a Multi-Knife-Edge Slit Collimator-based Prompt Gamma Ray Imaging System
基于多刀口狭缝准直器的瞬发伽马射线成像系统的临床成像性能评估
- 批准号:
10511964 - 财政年份:2022
- 资助金额:
$ 53.05万 - 项目类别:
Low cost and high performance time-of-flight PET detectors
低成本、高性能飞行时间 PET 探测器
- 批准号:
10569636 - 财政年份:2020
- 资助金额:
$ 53.05万 - 项目类别:
Low cost and high performance time-of-flight PET detectors
低成本、高性能飞行时间 PET 探测器
- 批准号:
10380854 - 财政年份:2020
- 资助金额:
$ 53.05万 - 项目类别:
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