Positive Psychology Intervention for Spanish-speaking Hispanic/Latino Adults at Risk for Cardiovascular Disease

对有心血管疾病风险的西班牙语裔/拉丁裔成年人进行积极心理学干预

• 批准号: 9973165
• 负责人: Rosalba Hernandez
• 金额: $ 16.43万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9973165
• 关键词: Acculturation; Adult; Affective; American Heart Association; Antihypertensive Agents; Autonomic nervous system; Behavior; Biological Markers; Blood Pressure; Brain; C-reactive protein; Cardiac; Cardiac health; Cardiology; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Church; Clinical; Clinical Psychology; Clinical Trials Design; Cluster randomized trial; Cognitive; Communities; Competence; Country; Data; Development; Disease; Disease Progression; Educational Curriculum; Effectiveness; Emotional; Endothelium; Environment; Evidence based intervention; Exercise; Faculty; Functional disorder; Funding; Goals; Happiness; Health; Health behavior; Heart; High Prevalence; Hispanic Community Health Study/Study of Latinos; Hispanics; Hour; Hypertension; Illinois; Incidence; Individual; Inflammatory; Intervention; K-Series Research Career Programs; Latino; Letters; Life; Link; Measures; Mentors; Mentorship; Methodology; Mexican; Minority; Modification; Observational Study; Outcome; Participant; Pharmaceutical Preparations; Physicians; Physiological; Population; Prevention strategy; Preventive; Process; Psychology; Randomized Clinical Trials; Relaxation Techniques; Reporting; Research; Research Personnel; Research Project Grants; Risk; Risk Factors; Sampling; Testing; Therapeutic; Training; Treatment Cost; Treatment Efficacy; United States National Institutes of Health; Universities; Well in self; Woman; arm; attentional control; base; behavioral adherence; biobehavior; cardiovascular disorder epidemiology; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular health; career; clinical efficacy; clinically significant; cohort; design; disadvantaged population; disorder prevention; efficacy testing; epidemiology study; experience; gratitude; heart rate variability; improved; innovation; interest; men; mortality; novel; optimism; post intervention; programs; prospective; psychologic; psychosocial; public health relevance; randomized trial; research data dissemination; secondary analysis; skills; social

Abstract: Project Description The Hispanic/Latino (H/L) population in the US has a disproportionately higher prevalence of cardiovascular disease (CVD) risk factors. The proposed K01 Mentored Career Development Award to Promote Faculty Diversity will facilitate Dr. Rosalba Hernandez in establishing an independent research career with expertise in therapeutic psychosocial interventions for H/L adults with poor cardiovascular health. But, successful attainment of status as an independent investigator requires further training. Training objectives aim to increase her expertise in: clinical trials design; statistical methodology for randomized trials; physiological mechanisms of the brain-heart interaction and non-invasive cardiology; delivery of positive psychology interventions; and advanced skills in research dissemination and enhanced professional development. Training takes full advantage of the candidate's strong institutional support and environment at the University of Illinois. Observational studies demonstrate a robust association between positive psychological well-being (or `emotional well-being') and cardiovascular health, but experimental testing is required to assess whether interventions geared toward improving psychological well-being result in enhanced heart health. This proposal consists of two interrelated studies that together explore the link between psychological well-being and cardiac- health, with nuanced exploration of biobehavioral mechanisms. Using data of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) (n=16,415), we will examine the cross-sectional and prospective association between positive emotional well-being (e.g., optimism) and cardiovascular health, with in-depth exploration of plausible intermediaries such as autonomic nervous system activity, inflammatory biomarkers, and endothelial function. The large and heterogeneous HCHS/SOL cohort data allows identification of effect modifiers such as country of origin and level of acculturation, which is often not feasible in the context of a small experimental trial. We additionally propose implementation of a pilot cluster-randomized trial. A total of 126 H/L adults with uncontrolled hypertension will participate in a pilot cluster-randomized trial testing the efficacy of a positive psychology (PP) intervention. Efficacy of the PP intervention versus an attentional control arm will be assessed primarily for blood pressure, and secondarily for emotional well-being, health behavior adherence, heart rate variability, and C-reactive protein. The proposed studies will provide preliminary data to conduct a larger fully-powered RCT with pursuit of funding via an R01 mechanism. Dr. Hernandez will obtain critical skills through interdisciplinary mentorship from experts in cardiovascular epidemiology, non-invasive cardiology, and clinical psychology. Experiences gained from the proposed K01-related activities will provide the necessary competences for Dr. Hernandez to become a successful independent investigator.

摘要：项目描述 美国西班牙裔/拉丁裔（H/L）人群的心血管疾病患病率不成比例地更高， 疾病（CVD）的危险因素。建议的K 01辅导职业发展奖，以促进教师 多样性将促进博士Rosalba埃尔南德斯在建立一个独立的研究生涯， 对心血管健康状况不佳的H/L成人进行治疗性心理社会干预。但是，成功 获得独立调查员的地位需要进一步培训。培训目标旨在 增加她在以下方面的专业知识：临床试验设计;随机试验的统计方法;生理学 脑-心相互作用的机制和非侵入性心脏病学;积极心理学的传递 干预措施;以及研究传播和加强专业发展方面的先进技能。培训 充分利用候选人在伊利诺伊大学强大的机构支持和环境。 观察性研究表明，积极的心理健康（或 “情绪健康”）和心血管健康，但需要进行实验测试，以评估 旨在改善心理健康的干预措施可增强心脏健康。这项建议 包括两项相互关联的研究，共同探讨心理健康和心脏之间的联系， 健康，并对生物行为机制进行了细致入微的探索。使用西班牙裔社区健康数据 研究/拉丁美洲人的研究（HCHS/SOL）（n= 16，415），我们将检查横断面和前瞻性 积极的情绪健康（例如，乐观）和心血管健康，深入 探索合理的中介物，如自主神经系统活动，炎症生物标志物， 和内皮功能。大型异质性HCHS/SOL队列数据允许识别效应 修饰语，如原籍国和文化适应程度，这往往是不可行的背景下， 小型实验性试验我们还建议实施一项试点随机分组试验。共 126例高血压未得到控制的H/L成人将参加一项试验性随机分组试验， 积极心理学（PP）干预的有效性。PP干预与注意力控制的有效性 手臂将主要评估血压，其次是情绪健康，健康行为 依从性、心率变异性和C反应蛋白。 拟议的研究将提供初步数据，以进行更大规模的全把握度RCT， 通过R 01机制提供资金。埃尔南德斯博士将通过跨学科指导获得关键技能 来自心血管流行病学、非侵入性心脏病学和临床心理学的专家。经验 从拟议的K 01相关活动中获得的知识将为埃尔南德斯博士提供必要的能力， 成为一名成功的独立调查员。

项目成果

A Web-Based Positive Psychological Intervention to Improve Blood Pressure Control in Spanish-Speaking Hispanic/Latino Adults With Uncontrolled Hypertension: Protocol and Design for the ¡Alégrate! Randomized Controlled Trial.

基于网络的积极心理干预，以改善患有不受控制的高血压的西班牙语西班牙裔/拉丁裔成年人的血压控制：Alégrate 的协议和设计！

• DOI: 10.2196/17721
• 发表时间: 2020
• 期刊: JMIR research protocols
• 影响因子: 1.7
• 作者: Hernandez,Rosalba;Cohn,Michael;Hernandez,Alison;Daviglus,Martha;Martinez,Lizet;Martinez,Angela;Martinez,Itzel;Durazo-Arvizu,Ramon;Moskowitz,Judith
• 通讯作者: Moskowitz,Judith

Mindfulness-based Virtual Reality Intervention in Hemodialysis Patients: A Pilot Study on End-user Perceptions and Safety.

基于正念的虚拟现实干预血液透析患者：最终用户认知和安全的试点研究。

• DOI: 10.34067/kid.0005522020
• 发表时间: 2021
• 期刊: Kidney360
• 作者: Hernandez,Rosalba;Burrows,Brett;Browning,MatthewHEM;Solai,Killivalavan;Fast,Drew;Litbarg,NataliaO;Wilund,KennethR;Moskowitz,JudithT
• 通讯作者: Moskowitz,JudithT

Author Reply: Illuminating the Health Benefits of Psychological Assets.

作者回复：阐明心理资产对健康的益处。

• DOI: 10.1177/1754073917728384
• 发表时间: 2018
• 期刊: Emotion review : journal of the International Society for Research on Emotion
• 作者: Hernandez,Rosalba;Bassett,SarahM;Schuette,StephanieA;Shiu,EvaW;Moskowitz,JudithT
• 通讯作者: Moskowitz,JudithT

Psychological Well-being and Physical Health: Associations, Mechanisms, and Future Directions.

• DOI: 10.1177/1754073917697824
• 发表时间: 2018-01
• 期刊: EMOTION REVIEW
• 影响因子: 5.4
• 作者: Hernandez, Rosalba;Bassett, Sarah M.;Boughton, Seth W.;Schuette, Stephanie A.;Shiu, Eva W.;Moskowitz, Judith T.
• 通讯作者: Moskowitz, Judith T.

Feasibility of a culturally adapted positive psychological intervention for Hispanics/Latinos with elevated risk for cardiovascular disease.

对心血管疾病风险较高的西班牙裔/拉丁裔进行适应文化的积极心理干预的可行性。

• DOI: 10.1093/tbm/iby045
• 发表时间: 2018
• 期刊: Translational behavioral medicine
• 影响因子: 3.6
• 作者: Hernandez,Rosalba;Cheung,Elaine;Carnethon,Mercedes;Penedo,FrankJ;Moskowitz,JudithT;Martinez,Lizet;Schueller,StephenM
• 通讯作者: Schueller,StephenM