Resource Core

资源核心

• 批准号: 9973346
• 负责人: Deborah Requesens
• 金额: $ 142.26万
• 依托单位: CORIELL INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9973346
• 关键词: Advertisements; Area; Biocompatible Materials; Biomedical Research; Catalogs; Cell Line; Cells; Chromosome abnormality; Clinical; Collection; Communities; Custom; DNA; Databases; Development; Diagnosis; Educational process of instructing; Electronic Mail; Exhibits; Family; Foundations; Funding Opportunities; Genetic Diseases; Genetic Research; Genetic Services; Geography; Goals; Hereditary Disease; Human; Human Genetics; Individual; Information Distribution; Institutes; Institutional Review Boards; Interview; Journals; Life; Maintenance; Medical Research; Mission; National Institute of General Medical Sciences; Newsletter; Pamphlets; Patients; Preparation; Prevention; Procedures; Process; Protocols documentation; Quality Control; RNA; Reporting; Research Personnel; Research Support; Resources; Sampling; Secure; Services; Technology; Testing; Update; cell repository; computerized; disease diagnosis; established cell line; high standard; induced pluripotent stem cell; innovation; interest; meetings; permanent cell line; repository; response; social media

The NIGMS Human Genetic Cell Repository U42 Application FOA No.: RFA-GM-19-002 Project Summary/Abstract Coriell Institute for Medical Research (Coriell) proposes to maintain and expand the NIGMS Human Genetic Cell Repository (HGCR). The NIGMS HGCR, established in 1972 at Coriell by the National Institute of General Medical Sciences (NIGMS), provides a readily accessible, centralized resource for biospecimens from individuals with inherited disorders, chromosomal abnormalities, apparently healthy individuals, and individuals of diverse geographic origins for use in biomedical research. The primary goal of the NIGMS HGCR is to stimulate and facilitate biomedical research, teaching, and the diagnosis and prevention of human genetic diseases by establishing and maintaining a repository of high quality, uncontaminated, well characterized, and clinically well-documented cell lines and DNA and making these resources available to investigators throughout the U.S. and abroad. The NIGMS HGCR mission is in line with the NIGMS mission, which is “to support research that increases understanding of life processes and lays the foundation for advances in disease diagnosis, treatment and prevention”. The NIGMS HGCR’s activities, all governed by high standards of quality, will include (1) collection, establishment, characterization, maintenance, and distribution of cell lines, (2) preparation, storage and distribution of DNA from cell lines, (3) the development and offering of special genetic services and biomaterials in response to customer requests, (4) maintenance of a comprehensive database and online catalog, and (5) publicizing the NIGMS HGCR’s collections. The NIGMS HGCR will maintain, grow and distribute the current collection of approximately 11,800 unique cell lines, 6,400 DNA samples, and 54 human iPSC lines in its online catalog, as well as newly acquired resources. The NIGMS HGCR will continue to create human induced pluripotent stem cell (iPSC) lines at Coriell by reprogramming certain NIGMS HGCR cell lines. Additionally, Coriell is committed to integrating state-of-the-art technologies into its activities and will continue to offer a wide range of cutting edge services that enhance the utility of the HGCR collection to the genetic research community.

NIGMS人类遗传细胞库