Brain Connectivity and Self-Reported Cancer Related Cognitive Impairment

项目摘要/摘要 候选人Ashley Henneghan博士的长期职业目标是开发有效的治疗方法 减少或预防自我报告癌症相关认知障碍的方法(SR-CRCI)，通过 整合神经影像数据的多学科协作研究，特别是与SR-CRCI相关的数据。 目前文献中的空白使得人们很难理解SR-CRCI的机制，以及SR-CRCI是如何相似的 或者不同于心理痛苦，以及预测癌症治疗后sr-CRCI发生率的因素。 为了继续朝着她的首要职业目标前进，候选人将纵向审查SR-CRCI， 大脑连通性(使用功能磁共振成像)和心理痛苦，来自手术前 在89名乳腺癌幸存者和50名匹配的对照队列中，治疗后一年的基线。三 具体的研究目标是在一项回溯性纵向研究中提出的，以(1)确定在 高sr-CRCI的BC幸存者、低sr-CRCI的BC幸存者和健康对照组之间的脑连接， (2)根据痛苦的严重程度比较幸存者群体之间的脑连接模式，以及(3)探索 卑诗省幸存者的sr-crci模型、心理困扰和脑连接。候选人的前一次 培训和研究经验使她做好了从事这项研究的准备，但她还需要继续 在四个关键领域提供指导，以完成拟议的项目并实现她的职业目标。一位专家 已经选择了多学科导师团队来监督Henneghan博士的培训和进展 她对此K01提案的短期目标是：(1)获得在概念上使用fMRI数据的知识和技能 专门与连接学相关的认知研究，(2)发展纵向研究设计的熟练程度 和方法，(3)增加乳腺癌的病因和治疗知识，(4)加强和完善 成为一名成功的独立调查员所需的技能。为此开展的培训和研究活动 K01提案将重点对候选人的初选进行二次回溯数据分析 Mentor对BC患者和健康对照队列的纵向研究(R01CA172145)。设施和 德克萨斯大学奥斯汀分校的其他资源为该提案的合作者提供了丰富的 支持科学研究的环境和合作研究的成功历史 癌症和认知领域。该项目解决了NINR战略计划的高度优先事项，以探索 疾病症状的潜在机制，并开发针对这些症状的个性化治疗 通过症状科学研究的机制。K01奖将提供一个重要的机会 受保护的时间，以提高应聘者的技能并获得必要的培训和专业知识，以便 进行拟议的研究，并将研究结果应用于新的调查员R01提案。候选人是 致力于长期从事独立肿瘤学研究，专注于症状科学。

PROJECT SUMMARY/ABSTRACT The candidate, Dr. Ashley Henneghan's long term career goal is to develop effective therapeutic treatment approaches to reduce or prevent self-reported cancer related cognitive impairments (sr-CRCI), through collaborative multi-disciplinary research that integrates neuroimaging data, specifically related to sr-CRCI. Current gaps in the literature make it difficult to understand the mechanisms of sr-CRCI, how sr-CRCI is similar or different to psychological distress, and what predicts the incidence of sr-CRCI following cancer treatment. To continue progress towards her overarching career goal, the candidate will longitudinally examine sr-CRCI, brain connectivity (using functional magnetic resonance imaging), and psychological distress, from pre-surgical baseline to 1-year post treatment in a cohort of 89 breast cancer survivors and 50 matched controls. Three specific research aims are proposed in a retrospective longitudinal study to (1) determine the differences in brain connectivity among BC survivors with high sr-CRCI, BC survivors with low sr-CRCI, and healthy controls, (2) compare brain connectivity patterns among groups of survivors based on distress severity, and (3) explore models of sr-CRCI, psychological distress, and brain connectivity in BC survivors. The candidate's previous training and research experience have prepared her to undertake this research, but she requires continued mentorship in four critical areas to complete the proposed project and achieve her career goals. An expert multi-disciplinary mentor team has been selected to oversee Dr. Henneghan's training and progress towards her short term goals for this K01 proposal to (1) gain knowledge and skills in conceptually using fMRI data in cognitive research specifically related to connectomics, (2) develop proficiency in longitudinal research design and methods, (3) increase knowledge of breast cancer etiology and treatment, and (4) enhance and refine skills requisite for a successful career as an independent investigator. Training and research activities for this K01 proposal will focus on conducting a secondary retrospective data analysis of the candidate's Primary Mentor's longitudinal study of a cohort of BC patients and healthy controls (R01CA172145). The facilities and other resources at the University of Texas at Austin provide the collaborators of this proposal with a rich environment that is supportive of scientific research and a history of successful collaborative research in the areas of cancer and cognition. The project addresses a high priority of the NINR strategic plan to explore the mechanisms underlying symptoms of illness and developing personalized treatments that address these mechanisms through symptom science research. The K01 Award would provide a vital opportunity for protected time to enhance the candidate's skills and gain the necessary training and expertise in order to conduct the proposed study and apply the findings to a new investigator R01 proposal. The candidate is committed to a long career as an independent oncology researcher with a focus on symptom science.