Brain Connectivity and Self-Reported Cancer Related Cognitive Impairment

大脑连接和自我报告的癌症相关认知障碍

• 批准号: 9974751
• 负责人: Ashley M. Henneghan
• 金额: $ 9.17万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-20 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9974751
• 关键词: Address; Advisory Committees; Aftercare; Anxiety; Area; Attention; Behavior Therapy; Brain; Breast Cancer Patient; Breast Cancer Treatment; Breast Cancer survivor; Cancer Etiology; Cancer Survivor; Clinical; Cognition; Cognitive; Data; Data Analyses; Distress; Early Intervention; Environment; Feeling; Functional Magnetic Resonance Imaging; Future; Goals; Gold; Impaired cognition; Impairment; Incidence; Interdisciplinary Study; International; Intervention; Investigation; Knowledge; Length; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Measures; Medical; Memory; Mental Depression; Mentored Research Scientist Development Award; Mentors; Mentorship; Methodology; Modality; Modeling; Moods; Neurobehavioral Manifestations; Neurobiology; Neurologic; Occupational; Oncology; Operative Surgical Procedures; Outcome; Patient Self-Report; Patients; Pattern; Phenotype; Population; Positioning Attribute; Prefrontal Cortex; Process; Quality of life; Recording of previous events; Reporting; Research; Research Activity; Research Design; Research Methodology; Research Personnel; Research Priority; Resources; Risk; Sampling; Severities; Standardization; Strategic Planning; Survivors; Symptoms; Testing; Texas; Time; Training; Training Activity; Treatment Efficacy; Universities; austin; base; cancer therapy; cancer-related cognitive impairment; career; chemotherapy; cognitive function; cognitive testing; cohort; connectome; depressive symptoms; emotion regulation; executive function; experience; follow-up; high risk; indexing; insight; malignant breast neoplasm; multidisciplinary; neurobiological mechanism; neuroimaging; neuroimaging marker; neuromechanism; personalized medicine; prevent; psychological distress; relating to nervous system; skills; social; symptom science; targeted treatment; theories; therapy development

PROJECT SUMMARY/ABSTRACT The candidate, Dr. Ashley Henneghan's long term career goal is to develop effective therapeutic treatment approaches to reduce or prevent self-reported cancer related cognitive impairments (sr-CRCI), through collaborative multi-disciplinary research that integrates neuroimaging data, specifically related to sr-CRCI. Current gaps in the literature make it difficult to understand the mechanisms of sr-CRCI, how sr-CRCI is similar or different to psychological distress, and what predicts the incidence of sr-CRCI following cancer treatment. To continue progress towards her overarching career goal, the candidate will longitudinally examine sr-CRCI, brain connectivity (using functional magnetic resonance imaging), and psychological distress, from pre-surgical baseline to 1-year post treatment in a cohort of 89 breast cancer survivors and 50 matched controls. Three specific research aims are proposed in a retrospective longitudinal study to (1) determine the differences in brain connectivity among BC survivors with high sr-CRCI, BC survivors with low sr-CRCI, and healthy controls, (2) compare brain connectivity patterns among groups of survivors based on distress severity, and (3) explore models of sr-CRCI, psychological distress, and brain connectivity in BC survivors. The candidate's previous training and research experience have prepared her to undertake this research, but she requires continued mentorship in four critical areas to complete the proposed project and achieve her career goals. An expert multi-disciplinary mentor team has been selected to oversee Dr. Henneghan's training and progress towards her short term goals for this K01 proposal to (1) gain knowledge and skills in conceptually using fMRI data in cognitive research specifically related to connectomics, (2) develop proficiency in longitudinal research design and methods, (3) increase knowledge of breast cancer etiology and treatment, and (4) enhance and refine skills requisite for a successful career as an independent investigator. Training and research activities for this K01 proposal will focus on conducting a secondary retrospective data analysis of the candidate's Primary Mentor's longitudinal study of a cohort of BC patients and healthy controls (R01CA172145). The facilities and other resources at the University of Texas at Austin provide the collaborators of this proposal with a rich environment that is supportive of scientific research and a history of successful collaborative research in the areas of cancer and cognition. The project addresses a high priority of the NINR strategic plan to explore the mechanisms underlying symptoms of illness and developing personalized treatments that address these mechanisms through symptom science research. The K01 Award would provide a vital opportunity for protected time to enhance the candidate's skills and gain the necessary training and expertise in order to conduct the proposed study and apply the findings to a new investigator R01 proposal. The candidate is committed to a long career as an independent oncology researcher with a focus on symptom science.

项目摘要/摘要 候选人Ashley Henneghan博士的长期职业目标是开发有效的治疗治疗 减少或预防自我报告的癌症相关认知障碍（SR-CRCI）的方法， 整合神经影像数据的协作多学科研究，与SR-CRCI特别相关。 文献中的当前差距使得很难理解SR-CRCI的机制，SR-CRCI如何相似 或与心理困扰不同，以及癌症治疗后SR-CRCI的发生率的原因。 为了继续朝着她的总体职业目标迈进，候选人将纵向研究SR-CRCI， 脑连接性（使用功能磁共振成像）和心理困扰，来自外科手术 在89个乳腺癌幸存者和50个匹配的对照组组成的队列中，基线至1年后治疗。三 在回顾性纵向研究中提出了具体的研究目的，以确定（1）确定的差异 卑诗省幸存者的大脑连通性，具有较低的SR-CRCI，BC幸存者，SR-CRCI和健康对照， （2）根据困扰严重程度比较幸存者群体之间的大脑连通性模式，（3）探索 BC幸存者中SR-CRCI，心理困扰和大脑连通性的模型。候选人的先前 培训和研究经验使她为进行这项研究做好了准备，但她要求继续 在四个关键领域进行指导，以完成拟议的项目并实现她的职业目标。专家 已选择多学科导师团队来监督Henneghan博士的培训和进步 她的此K01提案的短期目标（1）使用fMRI数据中的概念上获得知识和技能 认知研究与连接组特别相关，（2）发展纵向研究设计的熟练程度 和方法，（3）增加对乳腺癌病因和治疗的了解，以及（4）增强和完善 成功职业生涯所必需的技能。培训和研究活动 K01提案将重点侧重于对候选人的主要数据进行二次回顾性数据分析 导师对卑诗省患者和健康对照组的纵向研究（R01CA172145）。设施和 德克萨斯大学奥斯汀分校的其他资源为该提案的合作者提供了富人 支持科学研究和成功合作研究历史的环境 癌症和认知领域。该项目涉及NINR战略计划的高度优先事项，以探讨 疾病症状的基础机制和开发针对这些症状的个性化治疗 通过症状科学研究的机制。 K01奖将为 保护时间以提高候选人的技能并获得必要的培训和专业知识，以 进行拟议的研究，并将发现应用于新的研究者R01提案。候选人是 致力于作为独立肿瘤学研究人员的长期职业生涯，专注于症状科学。